{"title":"Making scents of mosquito repellents.","authors":"Cole J Meier, Minh N Nguyen, Christopher J Potter","doi":"10.1016/j.pt.2025.02.009","DOIUrl":null,"url":null,"abstract":"<p><p>Mosquitoes transmit deadly diseases. Chemical repellents deter mosquitoes from approaching or biting a human host and are an effective behavior-based method of personal protection. However, the current standards for selecting repellents often disregard their mode of action. This has likely led many potential repellents to be overlooked. Here, we discuss the sensory systems that underlie host-seeking behavior and how such behaviors are interrupted by repellents. We explore the behavioral assays used to identify repellents and how these have led a handful of contact repellents (DEET, picaridin, IR3535) to dominate the field. Finally, we consider how the development of spatial repellents may further protect against mosquito-borne diseases.</p>","PeriodicalId":23327,"journal":{"name":"Trends in parasitology","volume":" ","pages":""},"PeriodicalIF":7.0000,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in parasitology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.pt.2025.02.009","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PARASITOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Mosquitoes transmit deadly diseases. Chemical repellents deter mosquitoes from approaching or biting a human host and are an effective behavior-based method of personal protection. However, the current standards for selecting repellents often disregard their mode of action. This has likely led many potential repellents to be overlooked. Here, we discuss the sensory systems that underlie host-seeking behavior and how such behaviors are interrupted by repellents. We explore the behavioral assays used to identify repellents and how these have led a handful of contact repellents (DEET, picaridin, IR3535) to dominate the field. Finally, we consider how the development of spatial repellents may further protect against mosquito-borne diseases.
期刊介绍：
Since its inception as Parasitology Today in 1985, Trends in Parasitology has evolved into a highly esteemed review journal of global significance, reflecting the importance of medical and veterinary parasites worldwide. The journal serves as a hub for communication among researchers across all disciplines of parasitology, encompassing endoparasites, ectoparasites, transmission vectors, and susceptible hosts.
Each monthly issue of Trends in Parasitology offers authoritative, cutting-edge, and yet accessible review articles, providing a balanced and comprehensive overview, along with opinion pieces offering personal and novel perspectives. Additionally, the journal publishes a variety of short articles designed to inform and stimulate thoughts in a lively and widely-accessible manner. These include Science & Society (discussing the interface between parasitology and the general public), Spotlight (highlighting recently published research articles), Forum (presenting single-point hypotheses), Parasite/Vector of the Month (featuring a modular display of the selected species), Letter (providing responses to recent articles in Trends in Parasitology), and Trendstalk (conducting interviews). Please note that the journal exclusively publishes literature reviews based on published data, with systematic reviews, meta-analysis, and unpublished primary research falling outside our scope.
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