Zhang Lin, Yifan Wu, Yuqi Wang, Peipei Su, Xiaolin Li, Yang Zou, Kangbo Chen, Yaping Li, Jinfeng Zhou, Tingting Ye, Yiying Qi, Wei Wang
{"title":"Flexible Patterned Fuel Cell Patches Stimulate Nerve and Myocardium Restoration","authors":"Zhang Lin, Yifan Wu, Yuqi Wang, Peipei Su, Xiaolin Li, Yang Zou, Kangbo Chen, Yaping Li, Jinfeng Zhou, Tingting Ye, Yiying Qi, Wei Wang","doi":"10.1002/adma.202416410","DOIUrl":null,"url":null,"abstract":"The distribution of electrical potentials and current in exogenous electrostimulation has significant impacts on its effectiveness in promoting tissue repair. However, there is still a lack of a flexible, implantable power source capable of generating customizable patterned electric fields for in situ electrostimulation(electrical stimulation). Herein, this study reports a fuel cell patch (FCP) that can provide in situ electrostimulation and a hypoxic microenvironment to promote tissue repair synergistically. Stable and highly efficient PtNi nanochains and PtNi nanocages electrocatalysts with anti-interference properties catalyze glucose oxidation and oxygen reduction respectively in an encapsulation-free fuel cell. The laser-induced graphene (LIG) electrode loaded with PtNi electrocatalysts is transferred to the surface of a flexible chitosan hydrogel. The resulting flexible FCP can adapt to tissues with different morphologies, firmly adhere to prevent suturing, and provide potent electrostimulation (0.403 V, 51.55 µW cm<sup>−2</sup>). Additionally, it consumes oxygen in situ to create a hypoxic microenvironment, increasing the expression of hypoxia-inducible factor-1α (HIF-1α). Based on the different pattern requirements of exogenous electrostimulation during the repair of various types of tissue, an axial FCP for peripheral nerves and a flower-patterned FCP for myocardial tissue are constructed and transplanted into animals, showing significant tissue repair in both models.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"205 1","pages":""},"PeriodicalIF":27.4000,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Materials","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1002/adma.202416410","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
The distribution of electrical potentials and current in exogenous electrostimulation has significant impacts on its effectiveness in promoting tissue repair. However, there is still a lack of a flexible, implantable power source capable of generating customizable patterned electric fields for in situ electrostimulation(electrical stimulation). Herein, this study reports a fuel cell patch (FCP) that can provide in situ electrostimulation and a hypoxic microenvironment to promote tissue repair synergistically. Stable and highly efficient PtNi nanochains and PtNi nanocages electrocatalysts with anti-interference properties catalyze glucose oxidation and oxygen reduction respectively in an encapsulation-free fuel cell. The laser-induced graphene (LIG) electrode loaded with PtNi electrocatalysts is transferred to the surface of a flexible chitosan hydrogel. The resulting flexible FCP can adapt to tissues with different morphologies, firmly adhere to prevent suturing, and provide potent electrostimulation (0.403 V, 51.55 µW cm−2). Additionally, it consumes oxygen in situ to create a hypoxic microenvironment, increasing the expression of hypoxia-inducible factor-1α (HIF-1α). Based on the different pattern requirements of exogenous electrostimulation during the repair of various types of tissue, an axial FCP for peripheral nerves and a flower-patterned FCP for myocardial tissue are constructed and transplanted into animals, showing significant tissue repair in both models.
期刊介绍:
Advanced Materials, one of the world's most prestigious journals and the foundation of the Advanced portfolio, is the home of choice for best-in-class materials science for more than 30 years. Following this fast-growing and interdisciplinary field, we are considering and publishing the most important discoveries on any and all materials from materials scientists, chemists, physicists, engineers as well as health and life scientists and bringing you the latest results and trends in modern materials-related research every week.