Evaluation of the biological, physical, mechanical and chemical properties of orthodontic primer modified by nano-chitosan loaded with bioactive materials
Lara Riyadh Al-Banaa , Ali R. Al-Khatib , Fawzi Habeeb Jabrail
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Abstract
Objective
The primary objective was to evaluate the antibacterial and remineralizing effects of modified orthodontic primer containing nano-chitosan loaded with bioactive materials (gallic acid and calcium phosphate). The secondary objectives were to assess the physical, mechanical, and chemical properties of the adhesive primer.
Materials and methods
The chitosan loaded with gallic acid and calcium phosphate was prepared and characterized by FESEM-EDX. Then it was mixed with Transbond XT primer at two different concentrations to prepare 3 groups: Control, 5 % and 10 % Nano-Chitosan/Gallic acid + Calcium Phosphate Primer (NC/GACP). The primer groups were evaluated based on their Shear Bond Strength (SBS), Adhesive Remanent Index (ARI), Wettability, Degree of Conversion (DC), Antibacterial and Remineralization properties. Statistical analysis was conducted using one-way ANOVA and Tukey's post hoc test, all significant differences were set at P < 0.05.
Results
The modified primer groups containing 5 % and 10 % NC/GACP showed a significant increase (P < 0.05) in SBS and DC compared to the control group, with no significant differences observed in wettability. The ARI scores were mainly 3 meaning all the adhesive remained on the enamel after debonding. Additionally, both modified primer groups exhibited significant antibacterial activity (P < 0.05). Furthermore, the 5 % NC/GACP primer group showed the highest calcium and phosphate weight percentages and Ca/P ratio compared to the other groups (P < 0.05).
Conclusions
The orthodontic primer modified by nano-chitosan/gallic acid + calcium phosphate can be considered a novel antimicrobial and remineralizing adhesive that enhances the physical, chemical and mechanical properties of the adhesive.
期刊介绍：
Journal of Oral Biology and Craniofacial Research (JOBCR)is the official journal of the Craniofacial Research Foundation (CRF). The journal aims to provide a common platform for both clinical and translational research and to promote interdisciplinary sciences in craniofacial region. JOBCR publishes content that includes diseases, injuries and defects in the head, neck, face, jaws and the hard and soft tissues of the mouth and jaws and face region; diagnosis and medical management of diseases specific to the orofacial tissues and of oral manifestations of systemic diseases; studies on identifying populations at risk of oral disease or in need of specific care, and comparing regional, environmental, social, and access similarities and differences in dental care between populations; diseases of the mouth and related structures like salivary glands, temporomandibular joints, facial muscles and perioral skin; biomedical engineering, tissue engineering and stem cells. The journal publishes reviews, commentaries, peer-reviewed original research articles, short communication, and case reports.
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