Journal of oral biology and craniofacial research最新文献

Reduction in tongue space/tongue volume ratio as a risk factor for oral tongue squamous cell carcinoma-an exploratory study

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2025-04-23 DOI: 10.1016/j.jobcr.2025.04.002

Mahija Janardhanan , Sandya C.J , Manu Raj , Venkitachalam Ramanarayanan , Rajalakshmi G , Subramania Iyer K

Background

The occurrence of tongue cancers in young adults with no associated habitual risk factors is emerging as a major health concern. The objective of the study was to investigate the role of low tongue space-tongue volume ratio as a risk factor for oral tongue squamous cell carcinoma.

Methods

A case control study was conducted among histopathologically confirmed cases of squamous cell carcinoma of lateral border of the tongue who underwent treatment at the Department of Head & Neck Surgery (case group, n = 50). The patients with normal tongue referred for the evaluation of Magnetic Resonance Imaging of head region for other ailments formed the control group (n = 50). The space available for the tongue and the tongue volume of the study population were measured from the Magnetic Resonance Images (MRI), using in built software, and the mean Tongue space/Tongue volume ratio (TS/TV) of both the case group and the control group were calculated. A comparison of the TS/TV ratio was made between the test group and the control group using independent two sample t-test. The cut off value for TS/TV ratio between the groups was determined using Receiver Operating Characteristic (ROC) Curve method and Odds ratio was calculated by grouping the study population as low or high TS/TV ratio group using the cut off value obtained.

Results

A statistically significant variation was observed in the TS/TV ratio between tongue cancer patients and the normal controls with the mean value in normal controls higher than tongue cancer patients (p value = 0.009). The cut off value for TS/TV ratio for the development of tongue cancer was determined as 1.259 using ROC curve and the Odds ratio for malignant transformation in patients with low TS-TV ratio was calculated as 2.6.

Conclusion

A significant difference in TS/TV ratio between cases & normal controls observed in our study indicated that a lack of available space for the tongue either due to increase in tongue volume or decrease in tongue space may predispose an individual for the development of tongue cancer.

{"title":"Reduction in tongue space/tongue volume ratio as a risk factor for oral tongue squamous cell carcinoma-an exploratory study","authors":"Mahija Janardhanan , Sandya C.J , Manu Raj , Venkitachalam Ramanarayanan , Rajalakshmi G , Subramania Iyer K","doi":"10.1016/j.jobcr.2025.04.002","DOIUrl":"10.1016/j.jobcr.2025.04.002","url":null,"abstract":"<div><h3>Background</h3><div>The occurrence of tongue cancers in young adults with no associated habitual risk factors is emerging as a major health concern. The objective of the study was to investigate the role of low tongue space-tongue volume ratio as a risk factor for oral tongue squamous cell carcinoma.</div></div><div><h3>Methods</h3><div>A case control study was conducted among histopathologically confirmed cases of squamous cell carcinoma of lateral border of the tongue who underwent treatment at the Department of Head & Neck Surgery (case group, n = 50). The patients with normal tongue referred for the evaluation of Magnetic Resonance Imaging of head region for other ailments formed the control group (n = 50). The space available for the tongue and the tongue volume of the study population were measured from the Magnetic Resonance Images (MRI), using in built software, and the mean Tongue space/Tongue volume ratio (TS/TV) of both the case group and the control group were calculated. A comparison of the TS/TV ratio was made between the test group and the control group using independent two sample <em>t</em>-test. The cut off value for TS/TV ratio between the groups was determined using Receiver Operating Characteristic (ROC) Curve method and Odds ratio was calculated by grouping the study population as low or high TS/TV ratio group using the cut off value obtained.</div></div><div><h3>Results</h3><div>A statistically significant variation was observed in the TS/TV ratio between tongue cancer patients and the normal controls with the mean value in normal controls higher than tongue cancer patients (p value = 0.009). The cut off value for TS/TV ratio for the development of tongue cancer was determined as 1.259 using ROC curve and the Odds ratio for malignant transformation in patients with low TS-TV ratio was calculated as 2.6.</div></div><div><h3>Conclusion</h3><div>A significant difference in TS/TV ratio between cases & normal controls observed in our study indicated that a lack of available space for the tongue either due to increase in tongue volume or decrease in tongue space may predispose an individual for the development of tongue cancer.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 718-723"},"PeriodicalIF":0.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143858949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation and correlation of oral cancer phobia and anxiety in oral submucous fibrosis patients: A cross-sectional study

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2025-04-23 DOI: 10.1016/j.jobcr.2025.04.008

Ashita Ritesh Kalaskar , Gauri Ashok Somani , Ritesh Rambharose Kalaskar

Objective

Oral Cancer Phobia and anxiety in patients having premalignant conditions like Oral Submucous fibrosis (OSMF) needs to be evaluated so as to provide an overall effective management to these patients.

Methods & materials

Patients having OSMF were tested for oral cancer phobia and anxiety using the validated Marathi translation of CAI and 5-item version of the Spielberger State-Trait Anxiety Inventory (STAI) questionnaire respectively. The correlation was obtained for Oral cancer phobia, anxiety, and socio-demographic status.

Results

Cancer phobia and anxiety (mild to severe) were present in all the participants with the majority (65 %) having severe scores and significantly correlated with each other (p value < 0.001). Their scores significantly increased with an increase in grades of OSMF. A co-relation with socio-demographic profiles revealed females to be more affected by severe cancerophobia and anxiety. Patients with less education and housewives had greater levels of cancerophobia and anxiety. Housewives were also more concerned about acquiring cancer.

Conclusion

Cancer phobia and anxiety are prevalent in Oral Submucous Fibrosis patients highlighting the significance of identifying and providing psychological therapy as an important part of OSMF management protocol.

{"title":"Evaluation and correlation of oral cancer phobia and anxiety in oral submucous fibrosis patients: A cross-sectional study","authors":"Ashita Ritesh Kalaskar , Gauri Ashok Somani , Ritesh Rambharose Kalaskar","doi":"10.1016/j.jobcr.2025.04.008","DOIUrl":"10.1016/j.jobcr.2025.04.008","url":null,"abstract":"<div><h3>Objective</h3><div>Oral Cancer Phobia and anxiety in patients having premalignant conditions like Oral Submucous fibrosis (OSMF) needs to be evaluated so as to provide an overall effective management to these patients.</div></div><div><h3>Methods & materials</h3><div>Patients having OSMF were tested for oral cancer phobia and anxiety using the validated Marathi translation of CAI and 5-item version of the Spielberger State-Trait Anxiety Inventory (STAI) questionnaire respectively. The correlation was obtained for Oral cancer phobia, anxiety, and socio-demographic status.</div></div><div><h3>Results</h3><div>Cancer phobia and anxiety (mild to severe) were present in all the participants with the majority (65 %) having severe scores and significantly correlated with each other (p value < 0.001). Their scores significantly increased with an increase in grades of OSMF. A co-relation with socio-demographic profiles revealed females to be more affected by severe cancerophobia and anxiety. Patients with less education and housewives had greater levels of cancerophobia and anxiety. Housewives were also more concerned about acquiring cancer.</div></div><div><h3>Conclusion</h3><div>Cancer phobia and anxiety are prevalent in Oral Submucous Fibrosis patients highlighting the significance of identifying and providing psychological therapy as an important part of OSMF management protocol.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 724-728"},"PeriodicalIF":0.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143858947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The profiling and analysis of gene expression in rat temporomandibular joint disc tissue and its derived cells

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2025-04-21 DOI: 10.1016/j.jobcr.2025.03.018

Haruna Kashio , Rie Takai , Ayuko Takada , Yuya Nakao , Nattakarn Hosiriluck , Masahiro Iijima , Yoshihiro Abiko , Itaru Mizoguchi , Toshiya Arakawa

Objective

The temporomandibular joint (TMJ) disc is composed of a fibrocartilaginous connective tissue. Its dysfunction, resulting from excessive jaw movement, can lead to TMJ disorders. In this study, we aimed to investigate the crucial molecular information regarding the extracellular matrix (ECM), which would be necessary for treating such disorders through TMJ disc regeneration. To achieve this, we compared the gene profiles of TMJ disc tissues, their derived cells, and the periodontal ligament (PDL) in our previous study.

Methods

TMJ discs were isolated from male Wistar rats. Cells derived from the TMJ discs were cultured, and mRNA extracted from the disc tissues and derived cells was analyzed for gene profiling via microarray hybridization. Additionally, we compared the ECM expression between the TMJ disc and the PDL.

Results

Collagen (types I, II, III, and VI) and proteoglycans (biglycan and fibromodulin) were highly expressed in the TMJ discs. Significant reduction in decorin, fibromodulin and COL2 were observed in the TMJ-derived cells than in the tissue. Type VI collagen was the third most highly expressed in both the TMJ disc and PDL tissues, following types I and III.

Conclusions

Collagen types VI and II were prominently expressed, followed by collagen types I and III, in TMJ disc tissues, reflecting the unique functions of the disc. Type VI collagen was highly expressed in both TMJ disc and PDL tissues. Overall, type VI collagen might be a key molecule for TMJ disc regeneration, ensuring elasticity and cushioning, and could provide new insights for TMJ regeneration.

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引用次数: 0

Tooth shape asymmetry in post-canine dentition: Evidence-based morphometric insights

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2025-04-19 DOI: 10.1016/j.jobcr.2025.04.010

Srikant Natarajan , Junaid Ahmed , Shravan Shetty , Nidhin Philip Jose , Sharada Chowdappa , Sunita Carnelio

Background

This study investigates the potential existence of asymmetry in the shape of tooth and location of landmarks of tooth anatomy and its variation between sexes.

Methods

Our study evaluated dental symmetry in 160 patients aged 13–20 years, focusing on post-canine dentition. Using 3D geometric morphometrics, the research evaluated the variations in the anatomical landmarks between left and right side.

Results

Analysis of the landmarks revealed that 20–30 % of the principal components explained 80 % of the shape variation. No significant difference in centroid size was found between sexes, but significant shape differences were noted in all teeth except the 3-cusp type mandibular second premolar. Asymmetry was more in the premolar segment in the maxillary arch and in the two-cusp type of mandibular second premolar and the mandibular first molar in the mandibular arch.

Conclusion

The research underscores the evolutionary advantage of bilateral symmetry and the presence of fluctuating asymmetry, possibly linked to genetic or environmental stressors. It emphasizes the importance of understanding dental asymmetry for effective treatment planning and diagnosis, in restorative dentistry and orthodontics.

背景本研究调查了牙齿形状和牙齿解剖标志位置不对称的潜在存在及其性别差异。研究使用三维几何形态计量学评估了左右两侧解剖地标的差异。性别间的中心点大小无明显差异，但除下颌第二前臼齿为三尖牙外，其他牙齿的形状均存在明显差异。结论这项研究强调了双侧对称的进化优势，以及波动性不对称的存在，这可能与遗传或环境压力有关。它强调了了解牙齿不对称对有效的治疗计划和诊断、修复牙科和正畸的重要性。

{"title":"Tooth shape asymmetry in post-canine dentition: Evidence-based morphometric insights","authors":"Srikant Natarajan , Junaid Ahmed , Shravan Shetty , Nidhin Philip Jose , Sharada Chowdappa , Sunita Carnelio","doi":"10.1016/j.jobcr.2025.04.010","DOIUrl":"10.1016/j.jobcr.2025.04.010","url":null,"abstract":"<div><h3>Background</h3><div>This study investigates the potential existence of asymmetry in the shape of tooth and location of landmarks of tooth anatomy and its variation between sexes.</div></div><div><h3>Methods</h3><div>Our study evaluated dental symmetry in 160 patients aged 13–20 years, focusing on post-canine dentition. Using 3D geometric morphometrics, the research evaluated the variations in the anatomical landmarks between left and right side.</div></div><div><h3>Results</h3><div>Analysis of the landmarks revealed that 20–30 % of the principal components explained 80 % of the shape variation. No significant difference in centroid size was found between sexes, but significant shape differences were noted in all teeth except the 3-cusp type mandibular second premolar. Asymmetry was more in the premolar segment in the maxillary arch and in the two-cusp type of mandibular second premolar and the mandibular first molar in the mandibular arch.</div></div><div><h3>Conclusion</h3><div>The research underscores the evolutionary advantage of bilateral symmetry and the presence of fluctuating asymmetry, possibly linked to genetic or environmental stressors. It emphasizes the importance of understanding dental asymmetry for effective treatment planning and diagnosis, in restorative dentistry and orthodontics.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 703-711"},"PeriodicalIF":0.0,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of proximal contact tightness and contour of bioclear biofit HD versus Composi-tight 3DXR matrix systems in Class-II composite restoration: A randomized clinical study

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2025-04-19 DOI: 10.1016/j.jobcr.2025.04.005

Shreya Volety , Ajay Singh Rao , Karkala Venkappa Kishan , Nimisha C. Shah , Dikshit Solanki , Geetanjali Jain

Objective

To assess proximal contact tightness and contour of two different sectional matrix systems in class-II direct composite restoration using newly designed assessment criteria.

Materials and methods

In a double-blinded randomized clinical trial, 62 class-II direct composite restorations were performed in 62 patients using Composi-Tight 3DXR (n = 31) and Bioclear Biofit HD matrix systems (n = 31). Proximal contact tightness and contour were assessed using a self-designed criterion. Statistical analysis utilized Chi-Square and Independent sample t-test, with P < 0.001 considered significant.

Results

The mean ± sd score for clinical and radiographical evaluation of proximal contact tightness of the Bioclear Biofit HD group (1.06 ± 0.25) was statistically significant with a p-value (<0.001) compared to the Composi-Tight 3DXR group (2.39 ± 0.72).

Conclusion

The study found that the Bioclear Biofit HD matrix system demonstrated better proximal contact and contour than the Composi-Tight 3DXR Sectional Matrix System in Class-II direct composite restorations.

材料和方法在一项双盲随机临床试验中，使用Composi-Tight 3DXR（n = 31）和Bioclear Biofit HD基质系统（n = 31）为62名患者进行了62次II类直接复合树脂修复。使用自行设计的标准评估近端接触紧密度和轮廓。统计分析采用 Chi-Square 和独立样本 t 检验，认为 P < 0.001 具有显著性。结果 Bioclear Biofit HD 组临床和放射学评估近端接触紧密度的平均值（± sd）分（1.06 ± 0.25）与 Composlear Biofit HD 组相比具有显著性，P 值（< 0.001）与 Composi-Tight 3DXR 组（2.39 ± 0.72）相比具有统计学意义。结论该研究发现，在二类直接复合树脂修复体中，Bioclear Biofit HD 基质系统比 Composi-Tight 3DXR 切面基质系统显示出更好的近端接触和轮廓。

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引用次数: 0

Comparative evaluation of Microarc Oxidation and sandblasting on the retention of cement-retained implant restorations: An in-vitro study

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2025-04-18 DOI: 10.1016/j.jobcr.2025.04.004

Angelin Glory , Vidhya Jeyapalan , Jayakrishnakumar Sampathkumar , Hariharan Ramakrishnan , Shivakumar Baskaran , Deepavalli Arumuganainar

Purpose

The aim was to compare the impact of two distinct surface treatment methods on implant abutments concerning the retention of implant-supported restorations.

Materials and methods

30 implant analogs, individually embedded into blocks of autopolymerizing acrylic resin, were paired with 30 titanium implant abutments and divided into three groups (each, n = 10) based on surface treatment. Group I included untreated implant abutments; group II included abutments treated with sandblasting; and group III comprised abutments treated with Microarc Oxidation. A qualitative surface analysis was conducted using scanning electron microscope. Each abutment was connected to its analog embedded in the resin block. Resin copings were fabricated using rapid additive prototyping (3D printing) and cast into Ni-Cr alloy copings and cemented onto the abutments using zinc-polycarboxylate cement. Test samples were subjected to tensile bond strength (TBS) testing using an Axial-Torsion Servohydraulic Fatigue-Testing System. The results were tabulated and subjected to statistical evaluation.

Results

The mean TBS of the cemented cast copings on implant abutments was 4.276 MPa-group I; 6.340 MPa-group II; and 8.117 MPa-group III. Upon comparison, group III demonstrated the highest mean TBS, followed by group II, while group I exhibited the lowest strength. Qualitative surface analysis revealed that the test samples in group II and group III had greater surface roughness compared to those in group I.

Conclusion

The surface treatments of implant abutments using sandblasting and Microarc Oxidation enhanced the tensile bond strength of cemented cast copings and, MAO significantly increased retention of cement-retained restorations compared to sandblasting.

材料和方法将 30 个种植体模拟体分别嵌入自聚合丙烯酸树脂块中，与 30 个钛种植体基台配对，并根据表面处理情况分为三组（每组 n = 10）。第一组包括未经处理的种植基台；第二组包括经过喷砂处理的基台；第三组包括经过微弧氧化处理的基台。使用扫描电子显微镜对基台表面进行定性分析。每个基台都与嵌入树脂块中的模拟基台相连。使用快速添加原型（3D 打印）制作树脂基台，然后将其浇铸成镍铬合金基台，并使用聚羧酸锌水门汀将其粘结在基台上。使用轴向扭转伺服液压疲劳测试系统对测试样品进行拉伸结合强度（TBS）测试。结果种植体基台上的水门汀平均 TBS 值为：I 组 4.276 MPa；II 组 6.340 MPa；III 组 8.117 MPa。经比较，III 组的平均 TBS 值最高，其次是 II 组，而 I 组的强度最低。表面定性分析显示，与第一组相比，第二组和第三组的测试样本表面粗糙度更大。结论与喷砂法相比，使用喷砂法和微弧氧化法对种植基台进行表面处理可提高水门汀铸造基台的拉伸粘结强度，而且 MAO 能显著提高水门汀固位修复体的固位力。

{"title":"Comparative evaluation of Microarc Oxidation and sandblasting on the retention of cement-retained implant restorations: An in-vitro study","authors":"Angelin Glory , Vidhya Jeyapalan , Jayakrishnakumar Sampathkumar , Hariharan Ramakrishnan , Shivakumar Baskaran , Deepavalli Arumuganainar","doi":"10.1016/j.jobcr.2025.04.004","DOIUrl":"10.1016/j.jobcr.2025.04.004","url":null,"abstract":"<div><h3>Purpose</h3><div>The aim was to compare the impact of two distinct surface treatment methods on implant abutments concerning the retention of implant-supported restorations.</div></div><div><h3>Materials and methods</h3><div>30 implant analogs, individually embedded into blocks of autopolymerizing acrylic resin, were paired with 30 titanium implant abutments and divided into three groups (each, n = 10) based on surface treatment. Group I included untreated implant abutments; group II included abutments treated with sandblasting; and group III comprised abutments treated with Microarc Oxidation. A qualitative surface analysis was conducted using scanning electron microscope. Each abutment was connected to its analog embedded in the resin block. Resin copings were fabricated using rapid additive prototyping (3D printing) and cast into Ni-Cr alloy copings and cemented onto the abutments using zinc-polycarboxylate cement. Test samples were subjected to tensile bond strength (TBS) testing using an Axial-Torsion Servohydraulic Fatigue-Testing System. The results were tabulated and subjected to statistical evaluation.</div></div><div><h3>Results</h3><div>The mean TBS of the cemented cast copings on implant abutments was 4.276 MPa-group I; 6.340 MPa-group II; and 8.117 MPa-group III. Upon comparison, group III demonstrated the highest mean TBS, followed by group II, while group I exhibited the lowest strength. Qualitative surface analysis revealed that the test samples in group II and group III had greater surface roughness compared to those in group I.</div></div><div><h3>Conclusion</h3><div>The surface treatments of implant abutments using sandblasting and Microarc Oxidation enhanced the tensile bond strength of cemented cast copings and, MAO significantly increased retention of cement-retained restorations compared to sandblasting.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 663-669"},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143842594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the impact of Matrilin-1 gene polymorphisms on mandibular prognathism: A meta-analysis

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2025-04-18 DOI: 10.1016/j.jobcr.2025.03.019

Pooja Kurmi , Prasad Nalabothu , Shubhasmita Sahoo , Henu Kumar Verma , Srinivas Gosla Reddy , L.V.K.S. Bhaskar

Introduction

Matrilin-1 was shown to regulate the formation of cartilage matrix and to promote chondrocyte differentiation. This meta-analysis aims to synthesize evidence regarding the link between mandibular prognathism (MP) risk and the polymorphisms in the MATN1 gene.

Materials and methods

Relevant publications were retrieved by searching the PubMed, Web of Science, and Google Scholar databases. The association between MP and the MATN1 gene polymorphisms (rs20566, rs1065755) was assessed by calculating odds ratios (ORs) and 95 % CIs. Between studies, heterogeneity was identified using the Cochrane Q test and I² statistics. To assess the robustness of the meta-analysis sensitivity analysis was performed. The web tool MetaGenyo was used to conduct a meta-analysis.

Results

A total of four Asian and one Caucasian study were eventually taken for meta-analysis. Overall, the MATN1 rs20566 and rs1065755 polymorphisms are not associated with elevated risk of MP (rs20566 AA + AG versus GG OR = 1.35, 95 % CI = 0.32–5.67; rs1065755 TT + CT versus CC OR = 2.02, 95 % CI = 0.87–4.68). The degree of heterogeneity is found to be large for the MATN1 polymorphisms (for rs20566, I²⁼89 %, and for rs1065755, I²⁼60 %).

Conclusions

In conclusion, this meta-analysis did not provide evidence for the link between MATN1 polymorphisms and MP. However, the results conflict with the biological plausibility that matrilin-1 levels modulate cartilage development. Therefore, careful interpretation is needed, and further research is recommended.

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引用次数: 0

Influence of emotional intelligence on patient-dentist relationships: A questionnaire development, validation and pilot study

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2025-04-18 DOI: 10.1016/j.jobcr.2025.04.003

J Deepasakthi , Arthi Balasubramaniam , M. Karthik

Background

The Dentist-Patient relationship is a crucial component of successful dental care. Emotional intelligence (EI) has emerged as an important factor that can shape patient experiences and improve the quality of care. The present study was aimed to develop a questionnaire, validate the questionnaire, and assess how EI influences the dentist-patient relationship.

Materials and methods

This study was conducted in four phases. First phase was a focus group discussion with preliminary questionnaire development. Phase II was validation of the preliminary questionnaire and phase III was a pilot study that assessed the internal consistency of the preliminary questionnaire. Phase IV was the survey conducted to assess the influence of EI on dentist-patient relationship using the final questionnaire. A cross-sectional survey was conducted with 200 dentists in the month of September 2024.

Results

The CVI and CVR of the final questionnaire was found to be > 0.8 with κ = 81 % suggestive of good intra-rater agreement. The internal consistency of the final questionnaire was good with Cronbach's α value > 0.7. More than 40 % of the participants had an opinion that emotional intelligence helps in making ethical decisions in dental practice. Also, 41.5 % of the dentists suggested for a formal training in emotional intelligence in dental schools.

Conclusion

By fostering trust, improving communication, and managing emotional challenges, dental professionals can enhance the quality of care and patient experiences. Implementing EI-focused modules into dental curricula can better prepare future dentists to manage the emotional and psychological aspects of patient care.

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引用次数: 0

Comparative study of dentin remineralization with Nano-amorphous calcium phosphate-modified bioactive restoratives

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2025-04-18 DOI: 10.1016/j.jobcr.2025.04.009

Garima Tyagi , Sakshi Jain , Shivani Deshwal , Shubham Singh , Nikita Poonia , Shivangi Sharma

Objective

Modern caries management emphasizes minimally invasive techniques to promote remineralization through a balanced pH and mineral ion availability. Bioactive restorative materials, including giomer (Beautiful II, SHOFU Dental GmbH, Japan), and ACTIVA BioACTIVE (Pulpdent Corp., Watertown, MA, USA), release fluoride, calcium, and phosphate to enhance dentin remineralization. Nano-amorphous calcium phosphate (NACP) is a highly reactive mineral with proven remineralization capabilities due to its high surface area and solubility. The synergistic effects of NACP and the bioactive materials remain underexplored. This study evaluates the remineralization potential of giomer and ACTIVA BioACTIVE with and without NACP integration using energy-dispersive X-ray spectroscopy (EDX) microanalysis and Knoop hardness number (KHN) assessments.

Materials and methods

Four restorative composite materials: Beautifil II, Beautifil II with NACP, ACTIVA BioACTIVE, and ACTIVA BioACTIVE with NACP, were evaluated on demineralized dentin cavities created in non-carious molars. The mineral content (Ca, P, F) was analyzed via EDX, and the microhardness was measured using KHN. Statistical analyses included analysis of variance (ANOVA) and post hoc Tukey tests.

Results

NACP significantly increased calcium and phosphate deposition, with ACTIVA BioACTIVE with NACP demonstrating the highest remineralization (Ca/P ratio: 2.16). Fluoride intensities were higher in the giomer-based materials, promoting fluorapatite formation. KHN analysis revealed that Beautifil II with NACP exhibited the highest hardness, whereas ACTIVA BioACTIVE with NACP showed reduced hardness despite enhanced mineral content.

Conclusion

The incorporation of NACP into giomer and ACTIVA BioACTIVE facilitated the accumulation of calcium and phosphate ions, leading to enhanced mineralization.

{"title":"Comparative study of dentin remineralization with Nano-amorphous calcium phosphate-modified bioactive restoratives","authors":"Garima Tyagi , Sakshi Jain , Shivani Deshwal , Shubham Singh , Nikita Poonia , Shivangi Sharma","doi":"10.1016/j.jobcr.2025.04.009","DOIUrl":"10.1016/j.jobcr.2025.04.009","url":null,"abstract":"<div><h3>Objective</h3><div>Modern caries management emphasizes minimally invasive techniques to promote remineralization through a balanced pH and mineral ion availability. Bioactive restorative materials, including giomer (Beautiful II, SHOFU Dental GmbH, Japan), and ACTIVA BioACTIVE (Pulpdent Corp., Watertown, MA, USA), release fluoride, calcium, and phosphate to enhance dentin remineralization. Nano-amorphous calcium phosphate (NACP) is a highly reactive mineral with proven remineralization capabilities due to its high surface area and solubility. The synergistic effects of NACP and the bioactive materials remain underexplored. This study evaluates the remineralization potential of giomer and ACTIVA BioACTIVE with and without NACP integration using energy-dispersive X-ray spectroscopy (EDX) microanalysis and Knoop hardness number (KHN) assessments.</div></div><div><h3>Materials and methods</h3><div>Four restorative composite materials: Beautifil II, Beautifil II with NACP, ACTIVA BioACTIVE, and ACTIVA BioACTIVE with NACP, were evaluated on demineralized dentin cavities created in non-carious molars. The mineral content (Ca, P, F) was analyzed via EDX, and the microhardness was measured using KHN. Statistical analyses included analysis of variance (ANOVA) and post hoc Tukey tests.</div></div><div><h3>Results</h3><div>NACP significantly increased calcium and phosphate deposition, with ACTIVA BioACTIVE with NACP demonstrating the highest remineralization (Ca/P ratio: 2.16). Fluoride intensities were higher in the giomer-based materials, promoting fluorapatite formation. KHN analysis revealed that Beautifil II with NACP exhibited the highest hardness, whereas ACTIVA BioACTIVE with NACP showed reduced hardness despite enhanced mineral content.</div></div><div><h3>Conclusion</h3><div>The incorporation of NACP into giomer and ACTIVA BioACTIVE facilitated the accumulation of calcium and phosphate ions, leading to enhanced mineralization.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 684-690"},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143842596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physiotherapy in improving the interincisal mouth opening in oral submucous fibrosis: Meta-analysis

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2025-04-18 DOI: 10.1016/j.jobcr.2025.04.007

Ashish Bodhade , Alka Dive , Monal Yuwanati , Amol Gadbail , Dhara Dwivedi

Background

Oral submucous fibrosis (OSMF) is a chronic, irreversible collagen metabolic disorder resulting in progressive reduction of mouth opening due to submucosal fibrosis. Currently, the benefit of interincisal mouth opening (IMO) has been attributed to physical therapy. This meta-analysis aimed to find evidence about effectiveness of physiotherapy in increasing of IMO.

Method

Literature search was conducted in Scopus, Web of Science, and PubMed databases using "Oral submucous fibrosis", "OSMF", "OSF”, “treatment”, “treatment modalities", "physiotherapy devices", “mouth opening exercise device”, “mouth opening”, “mouth opening device”, and "physiotherapy" search terms to find the relevant studies published till March 2024. Studies evaluating the effectiveness of physiotherapy alone or in combination in improvement of IMO pre-post intervention in OSMF patients were included. Random-effect analysis was carried out to obtain the pooled IMO. Heterogeneity and publication bias was assessed using the I² and funnel plot. The main outcome variable was increase in IMO which was measured on linear scale.

Results

20 studies included in meta-analysis. Physiotherapy alone was found to be effective in improving IMO (4 studies; MD 1.19 [0.18, 2.20]). Further, addition of physiotherapy along with ultrasound (US) (3 studies; MD 3.96 [1.50, 6.42]), medicinal therapy including herbal (13 studies; MD 8.35 [5.18, 11.51]) and surgery (8 studies; MD 21.84 [18.29, 25.38]) improves the IMO.

Conclusion

There is evidence of effectiveness of physiotherapy in improving the IMO. However, evidence need to be substantiated with stringent methodology which is lacking in most of studies.

背景口腔黏膜下纤维化（OSMF）是一种慢性、不可逆的胶原代谢性疾病，由于黏膜下纤维化，导致张口度逐渐减小。目前，颚间张口（IMO）的益处主要归功于物理疗法。方法在 Scopus、Web of Science 和 PubMed 数据库中使用 "Oral submucous fibrosis"、"OSMF"、"OSF"、"treatment"、"treatment modalities"、"physicalotherapy devices"、"mouth opening exercise device"、"mouth opening"、"mouth opening device "和 "physicalotherapy "等检索词进行文献检索，查找截至 2024 年 3 月发表的相关研究。纳入的研究评估了物理治疗单独或联合使用对 OSMF 患者进行干预前 IMO 改善的有效性。采用随机效应分析法得出汇总的 IMO。使用 I2 和漏斗图评估异质性和发表偏倚。主要结果变量为IMO的增加，以线性量表进行测量。结果发现，单独使用物理治疗可有效改善 IMO（4 项研究；MD 1.19 [0.18, 2.20]）。此外，物理治疗与超声波（US）（3 项研究；MD 3.96 [1.50, 6.42]）、药物治疗（包括草药）（13 项研究；MD 8.35 [5.18, 11.51]）和手术（8 项研究；MD 21.84 [18.29, 25.38]）一起使用可改善 IMO。结论有证据表明物理治疗对改善 IMO 有效，但证据需要严格的方法证实，而大多数研究都缺乏这一点。

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引用次数: 0