Journal of oral biology and craniofacial research最新文献

Hydroxyapatite synthesis and characterization from marine sources: A comparative study 海洋来源羟基磷灰石的合成与表征：比较研究

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2024-09-27 DOI: 10.1016/j.jobcr.2024.09.009

Background

Hydroxyapatite (HAP) is a biocompatible material widely used in biomedical applications. Recent studies have explored various marine sources for HAP synthesis, demonstrating its potential for diverse applications.

Objective

This study aims to compare the characteristics of hydroxyapatite synthesized from sea shells and fish bones, specifically from the shells of Scylla olivacea (orange mud crab) and bones of Eleutheronema tetradactylum (fourfinger threadfin).

Materials & methods

HAP was synthesized from Scylla olivacea shells and Eleutheronema tetradactylum bones. The synthesized HAP underwent comprehensive characterization, including scanning electron microscopy (SEM) for structural analysis, hemocompatibility testing, antibacterial assays, and energy-dispersive X-ray spectroscopy (EDS) analysis.

Results

SEM revealed a complex structure of HAP with a clustered arrangement and biofilm-like features. HAP derived from crab shells exhibited superior structural properties compared to that from fish bones. Both sources demonstrated good hemocompatibility, essential for biomedical applications. The antibacterial assays indicated effective antibacterial properties for both HAP sources, with crab shell-derived HAP showing slightly better performance. EDS analysis confirmed the presence of key elements necessary for HAP, with a consistent composition in both sources.

Conclusion

Our study concludes that hydroxyapatite derived from Scylla olivacea shells exhibits superior properties compared to that from Eleutheronema tetradactylum bones. This research establishes a precedent for future investigations into other marine species, thereby broadening the scope and potential of hydroxyapatite synthesis from natural sources.

背景羟基磷灰石（HAP）是一种生物相容性材料，广泛应用于生物医学领域。本研究旨在比较由海贝和鱼骨合成的羟基磷灰石的特性，特别是由橘色泥蟹（Scylla olivacea）的贝壳和四指螺鳍鱼（Eleutheronema tetradactylum）的鱼骨合成的羟基磷灰石的特性。合成的 HAP 经过了全面的表征，包括扫描电子显微镜（SEM）结构分析、血液相容性测试、抗菌测试和能量色散 X 射线光谱（EDS）分析。与来自鱼骨的 HAP 相比，来自蟹壳的 HAP 表现出更优越的结构特性。两种来源的 HAP 都具有良好的血液相容性，这对生物医学应用至关重要。抗菌测试表明，两种 HAP 来源都具有有效的抗菌特性，其中蟹壳提取的 HAP 性能稍好。EDS 分析证实了 HAP 所需的关键元素的存在，两种来源的 HAP 成分一致。这项研究为今后研究其他海洋物种开创了先例，从而扩大了从天然来源合成羟基磷灰石的范围和潜力。

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引用次数: 0

Impact of FokI (rs2228570) and BglI (rs739837) polymorphisms in VDR gene on permanent tooth eruption: A cross-sectional study VDR 基因中的 FokI (rs2228570) 和 BglI (rs739837) 多态性对恒牙萌出的影响：一项横断面研究

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2024-09-27 DOI: 10.1016/j.jobcr.2024.09.012

Introduction

Genetic polymorphisms who disturb the mineral homeostasis during tooth development and eruption are candidate to clarify the molecular mechanisms involved in changes in the tooth eruption chronology. In this study, we evaluate whether the FokI (rs2228570) and BglI (rs739837) polymorphisms in the Vitamin D receptor (VDR) gene are associated with changes in the chronology of eruption of permanent teeth.

Material & method

This cross-sectional study randomly included 353 biologically unrelated children, both sexes, without systemic impairment or syndromes and history of trauma during the primary dentition. One operator perform the oral clinical examination. The tooth was considered erupted if there was a visible minimum of any tooth surface emerging from the mucosa. Genomic DNA was extracted from buccal epithelial cells from saliva samples. Genotyping was performed by Real-Time Polymerase Chain Reactions using TaqMan® technology. The average of the total number of erupted permanent teeth between the genotypes was compared by the Mann-Whitney test and multivariate Generalized Linear Models (GLM) (α = 5 %). β values with Confidence Interval (CI) 95 % were calculated.

Results

The heterozygous adenine-guanine genotype of the FokI significantly decreases the number of erupted permanent teeth (β = −1.15; CI 95 % = −2.22 to −0.07; p = 0.036). In the stratified analysis for maxillary and mandibular teeth, this genotype was associated with a decrease in the number of erupted maxillary permanent teeth (β = −0.65; CI 95 % = −1.22 to −0.09; p = 0.023). BglI was not associated with permanent teeth eruption.

Conclusion

The FokI, but not BglI, in the VDR may delay the eruption of permanent teeth.

引言在牙齿发育和萌出过程中，干扰矿物质平衡的基因多态性是阐明牙齿萌出时序变化的分子机制的候选基因。在这项研究中，我们评估了维生素 D 受体（VDR）基因中的 FokI（rs2228570）和 BglI（rs739837）多态性是否与恒牙萌出时序的变化有关。由一名操作员进行口腔临床检查。如果牙齿表面有可见的最小部分露出粘膜，则认为牙齿已经萌出。从唾液样本的颊上皮细胞中提取基因组 DNA。基因分型采用 TaqMan® 实时聚合酶链反应技术进行。通过曼-惠特尼检验和多变量广义线性模型（GLM）（α = 5 %）比较了不同基因型之间萌出恒牙总数的平均值。结果FokI的杂合子腺嘌呤-鸟嘌呤基因型会显著减少萌出恒牙的数量（β = -1.15; CI 95 % = -2.22 to -0.07; p = 0.036）。在上颌和下颌牙齿的分层分析中，该基因型与上颌恒牙萌出数量的减少有关（β = -0.65；CI 95 % = -1.22 至 -0.09；p = 0.023）。结论 VDR 中的 FokI（而非 BglI）可能会延迟恒牙萌出。

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引用次数: 0

Comparative evaluation of pediatric endodontic rotary file systems to bending and torsion tests: A finite element analysis 儿科牙髓旋转锉系统在弯曲和扭转测试中的比较评估：有限元分析

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2024-09-25 DOI: 10.1016/j.jobcr.2024.09.010

Background and objective

The introduction of Paediatric NiTi instruments has transformed the field of paediatric endodontics. However, no studies are available on the mechanical behaviour of these files, wherein Finite Element Analysis (FEA) was found to play a major role. The objective of this study is to evaluate the mechanical behavior of three commercially available pediatric endodontic rotary file systems to bending and torsion stress analysis test through Finite Element Analysis (FEA).

Methods

A Finite Element Analysis study was performed on three commercially available pediatric endodontic rotary files (Pro AF baby, Kedo SG and Neoendo pedoflex) available for cleaning and shaping the narrow root canals of the deciduous teeth to bending and torsion tests with the boundary conditions according to ISO 3630-1 specifications.

Results

In the bending analysis, Pro AF baby files were found to withstand the complete bending tests without yielding with a maximum von Mises stress of 1366 MPa, and Kedo SG, Neoendo Pedoflex file exhibited maximum von Mises stress of 2296 MPa, 1971 MPa. Under torsion tests Kedo SG exhibited maximum stress distribution, while Neoendo Pedoflex and Pro AF baby files exhibited similar stress distribution.

Conclusion

Pro AF baby file effectively withstood the rigorous 45 -degree bending examination without experiencing yielding, while Kedo SG file exhibited higher flexibility. Under torsional resistance test, all the three instruments exhibited similar stress distribution under the yield limit. In summary, the mechanical behaviour (bending and torsion) of pediatric rotary file systems were influenced by design of the files.

背景和目的儿童镍钛器械的引入改变了儿童牙髓病学领域。然而，目前还没有关于这些锉的机械性能的研究，而有限元分析（FEA）在其中发挥了重要作用。本研究的目的是通过有限元分析（FEA）评估三种市售儿童牙髓旋转锉系统在弯曲和扭转应力分析测试中的机械性能。方法对三种市售儿童牙髓旋转锉（Pro AF baby、Kedo SG 和 Neoendo pedoflex）进行了有限元分析研究，这些锉可用于清洁和修整乳牙的狭窄根管，并根据 ISO 3630-1 规范进行弯曲和扭转测试。结果在弯曲分析中，发现 Pro AF 宝宝牙粉能承受完全弯曲测试而不屈服，最大 von Mises 应力为 1366 兆帕，而 Kedo SG 和 Neoendo Pedoflex 牙粉的最大 von Mises 应力分别为 2296 兆帕和 1971 兆帕。在扭转测试中，Kedo SG 表现出最大的应力分布，而 Neoendo Pedoflex 和 Pro AF 婴儿锉表现出相似的应力分布。在抗扭测试中，三种器械在屈服极限下的应力分布相似。总之，儿科旋转锉系统的机械性能（弯曲和扭转）受锉刀设计的影响。

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引用次数: 0

Microbiological evaluation of vitamin C rich acerola mediated silver and copperoxide nanogel in treatment of periodontitis with and without diabetes mellitus 富含维生素 C 的针叶樱桃介导纳米银和氧化铜凝胶在治疗伴有或不伴有糖尿病的牙周炎中的微生物学评估

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2024-09-25 DOI: 10.1016/j.jobcr.2024.09.011

Aim

Nanotechnology presents a promising approach for managing chronic periodontitis, a common oral disease characterized by gum inflammation and loss of supporting bone around teeth. This study aimed to evaluate the antimicrobial efficacy of acerola-mediated silver nanoparticles (AgNPs) gel and copper oxide nanoparticles (CuONPs) gel in periodontitis patients with and without diabetes.

Materials and methods

The antimicrobial efficacy of acerola-mediated AgNPs gel and CuONPs nanogel was assessed using the agar well diffusion technique, Minimum Inhibitory Concentration (MIC) assay, Minimum Bactericidal Concentration (MBC) analysis, time-kill curve assay, and cytoplasmic and protein leakage analysis from periodontitis patients with and without diabetes.

Results

The study found that acerola-mediated AgNPs gel demonstrated more consistent and effective antimicrobial activity against periodontitis, with lower MIC and MBC values compared to the CuONPs gel, across all tested concentrations. These results suggest that acerola-mediated AgNPs gel may be a more effective and targeted therapeutic agent for periodontal disease management.

Conclusion

The findings emphasize the importance of nanoparticle gel concentration in optimizing periodontal treatment outcomes. Acerola-mediated AgNPs gel, with its superior efficacy and consistency in bactericidal activity, shows significant potential for periodontal therapy.

Clinical significance

Innovative nanoparticles like copper and silver oxides exhibit antibacterial, anti-inflammatory, and antioxidant properties, making them promising agents for targeting periodontal pathogens. Acerola (Malpighia emarginata), with its high vitamin C content and antioxidant properties, is beneficial in mitigating oxidative stress associated with chronic periodontitis.

目的纳米技术是治疗慢性牙周炎的一种很有前景的方法，慢性牙周炎是一种常见的口腔疾病，其特点是牙龈发炎和牙齿周围的支撑骨丧失。本研究旨在评估金雀花介导的银纳米粒子（AgNPs）凝胶和氧化铜纳米粒子（CuONPs）凝胶对患有和未患有糖尿病的牙周炎患者的抗菌效果。材料和方法采用琼脂井扩散技术、最低抑菌浓度（MIC）测定、最低杀菌浓度（MBC）分析、时间杀伤曲线测定以及细胞质和蛋白质渗漏分析，对患有和未患有糖尿病的牙周炎患者进行了金雀花介导的银纳米粒子凝胶和氧化铜纳米粒子凝胶的抗菌效果评估。结果研究发现，与 CuONPs 凝胶相比，在所有测试浓度下，金雀花介导的 AgNPs 凝胶对牙周炎表现出更一致、更有效的抗菌活性，其 MIC 值和 MBC 值均低于 CuONPs 凝胶。这些结果表明，以金针菜为媒介的 AgNPs 凝胶可能是一种更有效、更有针对性的牙周病治疗剂。临床意义铜和银氧化物等创新型纳米粒子具有抗菌、消炎和抗氧化特性，因此有望成为针对牙周病原体的药物。金雀花（Malpighia emarginata）具有高维生素 C 含量和抗氧化特性，有利于减轻与慢性牙周炎相关的氧化应激。

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引用次数: 0

Reliability and validity of a Hindi version of the Oral Health Impact Profile (OHIP-EDENT-H) for edentulous subjects: A Cross-Sectional study 针对无牙受试者的印地语版口腔健康影响档案（OHIP-EDENT-H）的可靠性和有效性：横断面研究

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2024-09-19 DOI: 10.1016/j.jobcr.2024.09.005

Aim

The study aimed to translate the OHIP-EDENT into Hindi and assess its validity and reliability.

Methods

The study included 150 participants whose demographic information was collected using the Modified Kuppuswamy Socio-economic Scale. The Oral Health Impact Profile in Edentulous (OHIP-EDENT) was translated into Hindi using the standard forward-backward method. Test-retest reliability was assessed using the Intra-class Correlation Coefficient (ICC) and internal consistency using Cronbach's alpha. The Kaiser-Meyer-Olkin (KMO) test and Bartlett's test of sphericity coefficient were used to conduct Exploratory Factor Analysis (EFA) and confirm the Construct validity. To establish Convergent validity, the relationship between the global question and the OHIP-EDENT-H subscale scores was observed.

Results

The data was analyzed with a confidence level of 95 %, and statistical significance was interpreted as a p-value of less than 0.05. The Cronbach's alpha score for OHIP-EDENT-H was 1.00, indicating high internal consistency. The corrected item-total correlations ranged from 0.665 to 0.923, and the total ICC score was 0.763, demonstrating good reliability. The subscales' intra-class correlation coefficient values ranged from 0.968 to 0.997, indicating high reliability. However, items 4, 6, 13, 17, 18, and 19 had factor loadings below the acceptable threshold of 0.40 in the factor analysis. Additionally, the total and subscale scores of the OHIP-EDENT-H showed significant correlations with global question, with correlation coefficients ranging from 0.665 to 0.923.

Conclusion

The Hindi version of OHIP-EDENT is a reliable and valid tool for evaluating the OHRQoL of Hindi-speaking edentulous individuals.

该研究旨在将 OHIP-EDENT 翻译成印地语，并评估其有效性和可靠性。研究方法该研究包括 150 名参与者，使用改良的 Kuppuswamy 社会经济量表收集其人口统计学信息。采用标准的前向-后向法将无牙颌口腔健康影响档案（OHIP-EDENT）翻译成印地语。使用类内相关系数（ICC）评估重测可靠性，使用克朗巴赫α评估内部一致性。采用 Kaiser-Meyer-Olkin (KMO) 检验和 Bartlett 球形系数检验来进行探索性因子分析 (EFA)，以确认结构效度。为确定收敛效度，观察了总体问题与 OHIP-EDENT-H 分量表得分之间的关系。OHIP-EDENT-H 的 Cronbach's alpha 得分为 1.00，表明其内部一致性较高。校正后的项目-总相关在 0.665 至 0.923 之间，总 ICC 得分为 0.763，显示出良好的可靠性。各分量表的类内相关系数为 0.968 至 0.997，表明信度较高。然而，在因子分析中，项目 4、6、13、17、18 和 19 的因子载荷低于 0.40 的可接受临界值。此外，OHIP-EDENT-H 的总分和分量表得分与总体问题有显著的相关性，相关系数在 0.665 到 0.923 之间。

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引用次数: 0

Assessment of pharyngeal airway space with MRI In oral submucous fibrosis: A cross-sectional observational study 用磁共振成像评估口腔黏膜下纤维化的咽部气道空间：横断面观察研究

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2024-09-19 DOI: 10.1016/j.jobcr.2024.09.003

Introduction

Oral submucous fibrosis (OSMF) alters the pharynx, which may affect airway size. MRI will be useful for diagnosing pharyngeal abnormalities. MRI is used to evaluate pharyngeal airway and soft palate changes in OSMF patients.

Materials and methods

This study is a cross-sectional observational study that included a sample size of 42 patients. Group A consisted of 21 patients with OSMF, while Group B consisted of 21 volunteers without OSMF, who served as the control group. The patients with OSMF were classified into Stages I, II, and III according to the categorization established by Pindborg JJ in 1989, Stop-Bang questionnaire was employed to assess obstructive sleep apnoea. Magnetic Resonance Imaging (MRI) was utilized to acquire evaluations of the pharyngeal airway, encompassing measurements in the midsagittal, cross-sectional width, length planes, and cross-sectional area with volume, for all participants. The Shapiro-Wilk test determines distribution normality. We utilized one-way ANOVA to compare the means between groups.

Results

The average age of OSMF patients was 45.9 ± 8.16, while the control group was 39.19 ± 4.21. Stage I of OSMF had the highest mean Stop Bang questionnaire score (2.75), followed by stage III (2.22), and stage II (1.75). Statistically significant differences (p < 0.001) were seen in volume, linear midsagittal planes, cross-sectional width and length planes, cross-sectional area, and soft palate breadth and length between OSMF and control groups.

Conclusion

MRI can effectively examine early changes in the pharyngeal airway of patients with OSMF thereby serving as a constructive diagnostic and motivational tool.

导言口腔黏膜下纤维化（OSMF）会改变咽部，从而影响气道的大小。核磁共振成像有助于诊断咽部异常。本研究是一项横断面观察性研究，样本量为 42 例患者。A 组包括 21 名 OSMF 患者，B 组包括 21 名无 OSMF 的志愿者，作为对照组。根据 Pindborg JJ 于 1989 年制定的分类法，将阻塞性睡眠呼吸暂停患者分为 I、II 和 III 期，并采用 Stop-Bang 问卷对阻塞性睡眠呼吸暂停进行评估。利用磁共振成像（MRI）对所有参与者的咽部气道进行评估，包括中矢状面、横截面宽度、长度平面和横截面面积与体积的测量。Shapiro-Wilk 检验确定了分布的正态性。结果OSMF患者的平均年龄为（45.9±8.16）岁，对照组为（39.19±4.21）岁。OSMF I 期患者的 Stop Bang 问卷平均得分最高（2.75），其次是 III 期（2.22）和 II 期（1.75）。OSMF组和对照组在体积、线性中轴平面、横截面宽度和长度平面、横截面面积以及软腭宽度和长度方面均存在统计学差异（p < 0.001）。

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引用次数: 0

Multi-disciplinary management of neonatal acute osteomyelitis of jaws: A report of 2 cases 新生儿急性颌骨骨髓炎的多学科治疗：2 个病例的报告

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2024-09-01 DOI: 10.1016/j.jobcr.2024.09.002

Background

Early diagnosis of neonatal osteomyelitis is often challenging due to the rarity of such cases and here we are presenting 2 case reports to add to the existing deficient literature. Case 1: A 15-day-old male infant presented with swelling and pus discharge from the anterior region of the mandible. Repeated culture and sensitivity tests revealed a transition from disseminated methicillin-sensitive S. aureus sepsis to methicillin-resistant sepsis. Moreover, there was swelling of the left elbow and right thigh. The Clinical diagnosis made was acute osteomyelitis of mandible associated with disseminated neonatal sepsis (LONS). A multidisciplinary approach was taken for the management by surgical debridement of the lesion alongwith removal of associated primary tooth buds, under specific antibiotic coverage. Case 2: A 20-day old male infant reported with pus discharge from upper lateral region of mouth past 10days. Personal history revealed, abscess in mother's right breast. A soft fluctuant pus pocket with draining sinus was present w.r.t.alveolar region of 54. CT revealed an osteolytic lesion of labial cortex of alveolar ridge in maxillary right first molar region. Pus specimen culture and sensitivity revealed growth of Staphylococcus aureus (MSSA). The clinical diagnosis of acute osteomyelitis of maxillawas made. Initially, antibiotics were prescribed which did not help and finally, surgical debridement accompanied by extraction of 54 tooth bud was done.

Conclusion

Acute osteomyelitis should always be considered as one of the differentials in infants with clinical signs of sepsis and Multidisciplinary management should be assured for the successful management of such cases.

背景由于新生儿骨髓炎病例罕见，因此其早期诊断往往具有挑战性，我们在此提供 2 例病例报告，以补充现有文献的不足。病例 1：一名 15 天大的男婴出现下颌骨前部肿胀和脓性分泌物。反复的培养和药敏试验显示，他从对甲氧西林敏感的金黄色葡萄球菌败血症转变为耐甲氧西林败血症。此外，左肘和右大腿也出现肿胀。临床诊断为急性下颌骨骨髓炎伴播散性新生儿败血症（LONS）。医生采取了多学科方法进行治疗，在特定抗生素的覆盖下，对病灶进行了手术清创，并切除了相关的原生牙芽。病例 2：一名 20 天大的男婴，10 天前口腔上外侧区域有脓性分泌物。个人病史显示，母亲右侧乳房有脓肿。在 54 号牙槽区有一个波动性软脓袋，内有引流窦。CT 显示上颌右侧第一磨牙区牙槽嵴部唇皮质有溶骨性病变。脓液标本培养和药敏结果显示生长了金黄色葡萄球菌（MSSA）。临床诊断为上颌骨急性骨髓炎。结论对于有败血症临床表现的婴儿，急性骨髓炎应始终被视为鉴别病例之一，并应确保多学科管理以成功治疗此类病例。

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引用次数: 0

Erratum regarding missing Ethical statements in previously published articles 关于以前发表的文章中缺少伦理声明的更正

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2024-09-01 DOI: 10.1016/j.jobcr.2024.09.007

引用次数: 0

Erratum regarding missing Ethical statements in previously published articles 关于以前发表的文章中缺少伦理声明的更正

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2024-09-01 DOI: 10.1016/j.jobcr.2024.09.006

引用次数: 0

Contextual barriers in effective interpersonal communication with patients: A qualitative analysis 与患者进行有效人际沟通的环境障碍：定性分析

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2024-09-01 DOI: 10.1016/j.jobcr.2024.09.004

Purpose

Competence building in interpersonal communication (IPC) between undergraduate students and patients requires deep understanding of the factors influencing their interaction. These factors, contextual to our clinical setup were explored from multisource perspectives to understand the perceived barriers in IPC.

Method

Qualitative hermeneutic phenomenological analysis was done for patient's semi-structured interviews (n = 16); interns (n = 15) and faculty (n = 14) unstructured focus group discussions. Three independent authors transcribed the data, derived codes and themes individually, and then collated and reflected on them to draw conclusions. Different collection methods, multisource perspectives, and multilevel analysis provided for triangulation and validation of the study results.

Results

This study's multisource feedback identified seven inter-dependent barriers to interpersonal communication between students and patients. They were time constraints, lack of trust and respect, cultural diversity, loco-regional linguistic differences, lack of empathy, illiteracy, and financial constraints.

Conclusions

The study concluded by identifying the unique set of barriers preventing interpersonal communication in our clinical microsystem. Addressing these contextual factors by preparing training modules and workshops would prepare undergraduate students for patient-centered care and partnership.

目的培养本科生与患者之间的人际沟通（IPC）能力需要深入了解影响他们互动的因素。方法对患者的半结构化访谈（n = 16）、实习生（n = 15）和教师（n = 14）的非结构化焦点小组讨论进行了诠释学现象学定性分析。三位独立作者对数据进行了誊写，分别得出了代码和主题，然后进行了整理和反思，得出了结论。不同的收集方法、多源视角和多层次分析为研究结果提供了三角测量和验证。这些障碍分别是时间限制、缺乏信任和尊重、文化多样性、地方-区域语言差异、缺乏同理心、文盲和经济限制。结论本研究最后确定了在我们的临床微观系统中阻碍人际沟通的一系列独特障碍。通过准备培训模块和研讨会来解决这些背景因素，将为本科生开展以患者为中心的护理和合作做好准备。

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引用次数: 0