Journal of oral biology and craniofacial research最新文献

Efficacy of canine-guided and bilateral balanced occlusion appliances in managing TMJ disc displacement with Reduction-A randomised clinical trial 犬引导和双侧平衡咬合矫治器治疗复位TMJ椎间盘移位的疗效-一项随机临床试验

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2026-01-31 DOI: 10.1016/j.jobcr.2026.101412

Renita Lorina Castelino , Chethan Hegde , Srikant Natarajan

Background

Among the intracapsular disorders of the temporomandibular joint (TMJ), disc displacement with reduction (DDwR) occurs most frequently. Canine-guided orthotic appliances may increase loading on the contralateral TMJ during eccentric movements due to the leverage effect generated on the working side whereas bilateral balanced occlusion appliances may promote uniform force distribution, reducing contralateral joint stress in patients with DDwR. Evidence comparing the effectiveness of canine-guided and bilateral balanced occlusion orthotic appliances in the management of DDwR remains limited.

Aim

This study compared the effectiveness of canine-guided and bilateral balanced occlusion orthotic appliances in reducing pain, assessed using the Visual Analog Scale (VAS), in patients with DDwR.

Material and methods

This study included 68 patients with painful TMJ DDwR (RDC/TMD Group IIa). Participants were randomly assigned to two groups: Group 1 received a canine-guided orthotic appliance, and Group 2 received a bilateral balanced occlusion orthotic appliance. Pain intensity was assessed using the VAS at baseline, 15, 30, and 90 days.

Results

Mann-Whitney U test was used for group comparisons which demonstrated Group 2 achieved significantly lower VAS scores during early assessments, while Group 1 exhibited more notable reductions between 30 and 90 days. Wilcoxon test was used to assess improvement within groups which demonstrated significant improvement in both the groups with p value < 0.001.

Conclusions

The bilateral balanced occlusion appliance produced faster pain reduction with lower VAS scores, particularly between 15 and 30 days. The canine-guided appliance showed greater pain reduction between 30 and 90 days. Both interventions effectively reduced pain.

背景：在颞下颌关节（TMJ）囊内疾病中，椎间盘移位伴复位（DDwR）最为常见。犬引导矫形器由于工作侧产生杠杆效应，偏心运动时对侧TMJ的负荷增加，而双侧平衡咬合器可促进力均匀分布，减少DDwR患者对侧关节应力。比较犬引导和双侧平衡矫形器在治疗DDwR中的有效性的证据仍然有限。目的本研究比较犬引导和双侧平衡矫形器在减轻DDwR患者疼痛方面的效果，采用视觉模拟量表（VAS）进行评估。材料与方法本研究纳入68例疼痛性TMJ DDwR患者（RDC/TMD IIa组）。参与者被随机分为两组：第一组使用犬引导矫形器，第二组使用双侧平衡咬合矫形器。在基线、15、30和90天使用VAS评估疼痛强度。结果采用mann - whitney U检验进行组间比较，结果显示2组在早期评估时VAS评分明显较低，而1组在30 - 90天之间表现出更显著的下降。采用Wilcoxon检验评估组内改善情况，两组均有显著改善（p值<； 0.001）。结论双侧平衡咬合器疼痛减轻更快，VAS评分更低，特别是在15 - 30天。犬类引导矫治器在30至90天内显示出更大的疼痛减轻。两种干预措施都有效地减轻了疼痛。

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引用次数: 0

Clinical translation of 3D bioprinting in oral and maxillofacial reconstruction: Recent progress and future directions 生物3D打印在口腔颌面重建中的临床应用：最新进展和未来方向

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2026-01-30 DOI: 10.1016/j.jobcr.2026.01.005

Shantanu Dixit , Maher AL. Shayeb , Goma Kathayat , Dinesh Rokaya

Background

Oral and maxillofacial reconstruction (OMF) requires regeneration of bone, soft tissue, vasculature, and nerves. Three-dimensional (3D) bioprinting offers a paradigm shift, enabling fabrication of patient-specific, cell-laden constructs designed to restore both anatomical form and biological function. This review presents an updated review on the clinical translation of 3D bioprinting in oral and maxillofacial reconstruction and presents future directions.

Methods

A comprehensive literature search was conducted in PubMed, Scopus, Web of Science, and Google Scholar for studies published up to June 2025, using search terms such as “3D bioprinting,” “bioink,” “OMF reconstruction,” and tissue-specific phrases. Extracted data addressed bioprinting strategies, biomaterials, and outcomes, which were synthesized into translational phases and tissue-specific applications.

Results

Four phases of translational progress were identified: (1) in vitro validation of bioinks and cell viability; (2) small-animal studies demonstrating osteogenesis, angiogenesis, and pulp–periodontal regeneration; (3) large-animal models addressing anatomical scalability and achieving partial functional integration; and (4) early human applications of acellular, patient-specific scaffolds. Success depends on tailoring bioinks—integrating stem cells, biomaterials, and signaling molecules—for tissues such as vascularized pulp, mineralized bone, and the periodontal ligament interface.

Conclusion

3D bioprinting holds transformative potential for OMF reconstruction. While progress is evident from bench to large-animal studies, clinical adoption of viable, cell-laden constructs remains elusive. Overcoming biofabrication, integration, and regulatory challenges through interdisciplinary collaboration will be critical to realize the promise of patient-specific, functional bioprinted OMF tissues in clinical practice.

背景：口腔颌面部重建（OMF）需要骨、软组织、脉管系统和神经的再生。三维（3D）生物打印提供了一种范式转变，使制造患者特异性，细胞负载结构的设计，以恢复解剖形式和生物功能。本文综述了生物3D打印在口腔颌面重建中的临床应用，并提出了未来的发展方向。方法在PubMed、Scopus、Web of Science、b谷歌Scholar等数据库中检索截至2025年6月发表的相关研究，检索词包括“3D bioprinting”、“bioink”、“OMF reconstruction”、组织特异性短语等。提取的数据涉及生物打印策略、生物材料和结果，这些数据被合成为翻译阶段和组织特异性应用。结果确定了四个阶段的转化进展：(1)生物链接和细胞活力的体外验证；(2)小动物研究显示骨生成、血管生成和牙髓-牙周再生；(3)解决解剖可扩展性和实现部分功能整合的大型动物模型；(4)脱细胞、患者特异性支架的早期人类应用。成功取决于定制生物墨水——整合干细胞、生物材料和信号分子——用于血管化牙髓、矿化骨和牙周韧带界面等组织。结论3d生物打印技术在OMF重建中具有革命性的潜力。虽然从实验到大型动物研究的进展很明显，但临床采用可行的、细胞负载的结构仍然难以捉摸。通过跨学科合作克服生物制造、整合和监管方面的挑战，将是实现患者特异性、功能性生物打印OMF组织在临床实践中的承诺的关键。

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引用次数: 0

Effect of dimethyl sulfoxide pretreatment on bonding of universal adhesives to pulp chamber dentin 二甲亚砜预处理对通用胶粘剂与牙本质粘接的影响

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2026-01-29 DOI: 10.1016/j.jobcr.2026.101409

Yashmin Parveen Karishma, Rajni Nagpal, Udai Pratap Singh, Sakshi Saumya, Shivani Deshwal

Aim and objective

To evaluate the effect of 50 % (v/v) dimethyl sulfoxide (DMSO) pretreatment on immediate (24 h) and delayed (6 months) microtensile bond strength (μTBS) of an etch-and-rinse adhesive and two universal adhesives to dentin.

Materials and methods

A total of 144 extracted human molars were decoronated, pulp chambers exposed, and roots sectioned 2 mm apical to the CEJ. Teeth were randomly divided into six experimental groups (n = 24), based on surface pretreatment and adhesive system used: Group 1A: Adper Single Bond 2 (ASB) Group 2A: Tetric N-Bond Universal (TNBU) Group 3A: Prime & Bond Universal (PNBU) Groups 1B, 2B, and 3B received the same adhesives, respectively, following a 50 % (v/v) DMSO wet bonding pretreatment. All adhesives were applied per manufacturer's instructions, followed by composite resin build-up. Ten samples per group were tested for μTBS at 24 h and ten after 6 months of storage. Failure mode was analyzed. Four additional samples per group underwent SEM evaluation to observe the resin–dentin interface.

Statistical analysis

Data were analyzed using one-way ANOVA and Tukey's post hoc test for intergroup comparisons. Unpaired t-tests were applied for two-group comparisons. Significance was set at p < 0.05.

Results

DMSO pretreatment significantly improved both immediate and long-term μTBS (p < 0.05) across all adhesives. PNBU exhibited the highest bond strength at both time intervals.

Conclusion

Dentin pretreatment with 50 % DMSO prior to adhesive application enhances immediate μTBS and preserves bond durability at 6 months, regardless of adhesive system used.

目的评价50% （v/v）二甲亚砜（DMSO）预处理对一种蚀刻冲洗胶粘剂和两种通用胶粘剂对牙本质的即时（24 h）和延迟（6个月）微拉伸结合强度（μTBS）的影响。材料和方法对144颗拔除的人磨牙进行装饰，露出牙髓腔，将牙根切成2 mm至CEJ。根据牙体表面处理和使用的粘结剂体系，随机分为6组（n = 24）： 1A组：Adper Single Bond 2 (ASB)， 2A组：tritric n -Bond Universal (TNBU)， 3A组：Prime &； Bond Universal (PNBU)， 1B、2B、3B组分别采用相同的粘结剂，采用50% (v/v) DMSO湿粘接预处理。所有胶粘剂都按照制造商的说明使用，然后是复合树脂堆积。贮藏24 h时每组10个样品，贮藏6个月后每组10个样品进行μTBS检测。分析了失效模式。每组增加4个样品进行扫描电镜观察树脂-牙本质界面。统计分析数据采用单因素方差分析和Tukey事后检验进行组间比较。两组比较采用非配对t检验。p <； 0.05为显著性。结果dmso预处理显著提高了所有胶粘剂的近期和长期μTBS （p < 0.05）。PNBU在两个时间间隔内均表现出最高的结合强度。结论无论采用何种粘接剂体系，使用50% DMSO预处理牙本质均可提高即刻μTBS，并保持6个月后粘接剂的耐久性。

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引用次数: 0

Assessment of Condyle-Sigmoid-Coronoid triangle, Gonial angle for age estimation and sex determination: A retrospective Orthopantomograph study 评估髁状突-乙状突-冠状三角、角对年龄估计和性别确定的影响：一项回顾性骨解剖研究

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2026-01-28 DOI: 10.1016/j.jobcr.2026.101411

K. Smrithy Sivadas, Kumuda Rao, Vidya Ajila, Yashika Jain

Background

Due to its sexual dimorphism, the mandible—a vital component of the human skull—is a valuable tool for sex determination in anthropological and forensic studies. Radiographs like an Orthopantomogram are quite useful in this regard for precise age and sex estimation. An essential component of the craniofacial complex, the mandibular angles provide information about the symmetry and vertical characteristics. Variations in the Condylar, Coronoidal, Sigmoidal, and Gonial angles have been observed with age, sex, and even dental status, as verified by radiographic and anthropometric research.

Aim

To evaluate Condylar angle, Sigmoidal angle, and Coronoidal angle by devising the Condyle-Sigmoid-Coronoid [CSC] Triangle along with the Gonial angle for sex determination and age estimation on a mandible devoid of teeth.

Materials and methods

200 Orthopantomograph images were attained, categorised into Group I and Group II, which consisted of males and females with ages ranging from 10 to 80 years, respectively. The CSC Triangle was devised by joining the highest point on these landmarks.

Results

The Condylar angle, Coronoidal angle, Sigmoidal angle composing the CSC triangle and the Gonial angle bilaterally were comparable between males and females with no statistically significant differences. The Condylar and coronoid angle had a higher score on the left side with the data demonstrating statistically significant results. The Sigmoidal angle and the Gonial angle were comparable between the right and left sides

Conclusion

Based on the statistical analysis, the difference noted with respect to the measured parameters indicates that these angles can help in sex determination and age estimation.

由于其性别二态性，下颌骨——人类头骨的重要组成部分——在人类学和法医研究中是一个有价值的性别确定工具。在这方面，像正体层摄影这样的x光片对于精确估计年龄和性别非常有用。作为颅面复合体的重要组成部分，下颌角提供了对称和垂直特征的信息。经x线摄影和人体测量学研究证实，髁状角、冠状角、乙状角和角状角的变化与年龄、性别甚至牙齿状况有关。目的通过设计髁-乙状体-冠状体[CSC]三角形及角形角来评估无牙下颌骨的髁状角、乙状体角和冠状角，用于性别鉴定和年龄估计。材料与方法获得200张正骨断层图像，分为ⅰ组和ⅱ组，分别为男性和女性，年龄在10 ~ 80岁之间。CSC三角是通过连接这些地标的最高点而设计的。结果构成CSC三角形的髁突角、冠状角、s形角和双侧角在男女之间具有可比性，差异无统计学意义。左侧髁突和冠状角评分较高，数据显示有统计学意义。左右两侧的s形角和Gonial角具有可比性。结论通过统计分析，所测参数的差异表明，这些角度可以帮助确定性别和估计年龄。

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引用次数: 0

Clinical resolution of oral lichenoid lesions after amalgam replacement: A systematic review and meta-analysis of observational studies 汞合金置换后口腔苔藓样病变的临床缓解：观察性研究的系统回顾和荟萃分析

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2026-01-28 DOI: 10.1016/j.jobcr.2026.01.008

Harshita Kothari , Ajinkya M. Pawar , Pankaj Gupta , Alexander Maniangat Luke , Mohamed Saleh Hamad Ingafou , Parmeet Banga , Mohmed Isaqali Karobari , Dian Agustin Wahjuningrum

Introduction

Oral lichenoid lesions (OLLs) can mimic oral lichen planus but are often linked to contact with dental amalgam. Replacement with biocompatible materials has been associated with lesion resolution, yet prior evidence lacked quantitative synthesis.

Materials and methods

Following PRISMA 2020 (PROSPERO: CRDXXXXXXXXXX2), eight databases (1986–2024) were searched for adult in vivo studies reporting OLL resolution after amalgam replacement. Two reviewers independently screened, extracted data, and assessed bias (ROBINS-I, Newcastle–Ottawa Scale, JBI). Random-effects meta-analysis estimated pooled odds ratios (OR) for clinical resolution; certainty was graded with GRADE.

Results

Of 2368 records, 35 studies were qualitatively synthesized and 11 entered meta-analysis (N = 365). Amalgam was replaced with glass ionomer, ceramics, composite resin, or gold alloys. Replacement markedly increased odds of lesion resolution (OR = 122.18; 95 % CI: 55.64–268.26; p < 0.001) with moderate heterogeneity (I² = 42 %). Risk of bias across observational studies was generally low to moderate. Funnel-plot asymmetry and Egger's test (p < 0.001) suggested publication bias; overall certainty was moderate. Subgroup analyses indicated greater benefit when lesions had direct amalgam contact, when patch testing was positive, and when ceramics or gold were used. Sensitivity analyses supported strength of the primary findings.

Conclusion

Amalgam replacement was linked with substantially higher odds of OLL resolution. However, between-study heterogeneity and indications of publication bias temper confidence in the pooled effect. Confirmatory, prospective, registered studies with standardized diagnostic criteria, outcome definitions, and material categories are needed to refine effect size estimates and strengthen certainty.

口腔苔藓样病变（OLLs）可以模拟口腔扁平苔藓，但通常与牙科汞合金接触有关。生物相容性材料的替代与病变消退有关，但先前的证据缺乏定量合成。材料和方法在PRISMA 2020 （PROSPERO: CRDXXXXXXXXXX2）之后，检索了8个数据库（1986-2024），以报告汞合金替代后OLL解决的成人体内研究。两位审稿人独立筛选、提取数据并评估偏倚（ROBINS-I, Newcastle-Ottawa Scale， JBI）。随机效应荟萃分析估计临床解决的合并优势比（OR）；确定性以GRADE分级。结果在2368份记录中，35项研究被定性合成，11项研究进入荟萃分析（N = 365）。汞合金被玻璃离子、陶瓷、复合树脂或金合金所取代。替代术显著增加病变消退的几率（OR = 122.18; 95% CI: 55.64-268.26; p < 0.001），异质性中等（I2 = 42%）。观察性研究的偏倚风险一般为低至中等。漏斗图不对称和Egger检验（p < 0.001）提示发表偏倚；总体确定性为中等。亚组分析表明，当病变直接接触银汞合金时，当斑贴试验呈阳性时，当使用陶瓷或黄金时，效果更大。敏感性分析支持了主要发现的强度。结论汞合金置换可显著提高OLL消退的几率。然而，研究间异质性和发表偏倚的迹象削弱了对合并效应的信心。需要具有标准化诊断标准、结果定义和材料类别的验证性、前瞻性、注册研究来完善效应量估计并加强确定性。

{"title":"Clinical resolution of oral lichenoid lesions after amalgam replacement: A systematic review and meta-analysis of observational studies","authors":"Harshita Kothari , Ajinkya M. Pawar , Pankaj Gupta , Alexander Maniangat Luke , Mohamed Saleh Hamad Ingafou , Parmeet Banga , Mohmed Isaqali Karobari , Dian Agustin Wahjuningrum","doi":"10.1016/j.jobcr.2026.01.008","DOIUrl":"10.1016/j.jobcr.2026.01.008","url":null,"abstract":"<div><h3>Introduction</h3><div>Oral lichenoid lesions (OLLs) can mimic oral lichen planus but are often linked to contact with dental amalgam. Replacement with biocompatible materials has been associated with lesion resolution, yet prior evidence lacked quantitative synthesis.</div></div><div><h3>Materials and methods</h3><div>Following PRISMA 2020 (PROSPERO: CRDXXXXXXXXXX2), eight databases (1986–2024) were searched for adult in vivo studies reporting OLL resolution after amalgam replacement. Two reviewers independently screened, extracted data, and assessed bias (ROBINS-I, Newcastle–Ottawa Scale, JBI). Random-effects meta-analysis estimated pooled odds ratios (OR) for clinical resolution; certainty was graded with GRADE.</div></div><div><h3>Results</h3><div>Of 2368 records, 35 studies were qualitatively synthesized and 11 entered meta-analysis (N = 365). Amalgam was replaced with glass ionomer, ceramics, composite resin, or gold alloys. Replacement markedly increased odds of lesion resolution (OR = 122.18; 95 % CI: 55.64–268.26; p < 0.001) with moderate heterogeneity (I<sup>2</sup> = 42 %). Risk of bias across observational studies was generally low to moderate. Funnel-plot asymmetry and Egger's test (p < 0.001) suggested publication bias; overall certainty was moderate. Subgroup analyses indicated greater benefit when lesions had direct amalgam contact, when patch testing was positive, and when ceramics or gold were used. Sensitivity analyses supported strength of the primary findings.</div></div><div><h3>Conclusion</h3><div>Amalgam replacement was linked with substantially higher odds of OLL resolution. However, between-study heterogeneity and indications of publication bias temper confidence in the pooled effect. Confirmatory, prospective, registered studies with standardized diagnostic criteria, outcome definitions, and material categories are needed to refine effect size estimates and strengthen certainty.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"16 2","pages":"Article 101404"},"PeriodicalIF":0.0,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146079977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Compressive and flexural strength of provisional crown materials fabricated by conventional and 3D printing techniques: An in vitro study 传统和3D打印技术制备的临时冠材料的抗压和弯曲强度：体外研究

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2026-01-27 DOI: 10.1016/j.jobcr.2026.101405

Nandini R.D., Nirupama R, Chetan Hegde

Purpose

To compare the mechanical properties of the new 3D Accuprint C&B resin against both conventional and other 3D-printed resins to determine its viability for provisional crown fabrication.

Materials and methods

Three materials were selected for comparison: GC Tempron (conventional), 3D Accuprint C&B, and Freeprint Temp (3D-printed resins). Fifteen cylindrical specimens (6 mm × 4 mm) were prepared from each material for compressive strength testing, and fifteen rectangular specimens (25 mm × 2 mm × 2 mm) were fabricated for flexural strength testing as per the manufacturer's instructions. Testing was performed using a universal testing machine. The recorded compressive and flexural strength values were statistically analyzed after confirming normality (Shapiro–Wilk test) and homogeneity (Levene's test). All statistical analyses were conducted using IBM SPSS Statistics software (version 25), with the level of significance set at p < 0.05. Data were analyzed using one-way ANOVA with Tukey's HSD test.

Results

Significant intergroup differences were found for both compressive and flexural strength (p < 0.001). GC Tempron showed significantly lower values compared with both 3D printed materials (p < 0.001). Freeprint Temp and 3D Accuprint did not differ significantly (compressive strength, p = 0.84; flexural strength, p = 0.15).

Conclusions

3D Accuprint C&B demonstrated superior mechanical strength compared to GC Tempron and comparable properties to Freeprint Temp. These findings confirm its mechanical viability as a high-performance alternative, making it better suited for durable provisional restorations, particularly in cases involving high resistance to stress, parafunctional habits, or implant-supported prostheses.

目的将新型3D Accuprint C&；B树脂与传统树脂和其他3D打印树脂的机械性能进行比较，以确定其用于临时冠制造的可行性。材料和方法选择三种材料进行比较：GC Tempron（常规）、3D Accuprint C&；B和Freeprint Temp （3D打印树脂）。每种材料制备15个圆柱形试件（6mm × 4mm）进行抗压强度试验，15个矩形试件（25mm × 2mm × 2mm）进行抗折强度试验。使用通用试验机进行测试。经证实正态性（Shapiro-Wilk检验）和均匀性（Levene检验）后，对记录的抗压和抗弯强度值进行统计学分析。采用IBM SPSS统计软件（version 25）进行统计分析，显著性水平设置为p <； 0.05。数据分析采用Tukey’s HSD检验的单因素方差分析。结果抗压和抗弯强度组间差异显著（p < 0.001）。与两种3D打印材料相比，GC Tempron的数值显著降低（p < 0.001）。Freeprint Temp和3D Accuprint没有显著差异（抗压强度，p = 0.84；抗弯强度，p = 0.15）。与GC Tempron相比，3d Accuprint C&；B具有更高的机械强度，与Freeprint Temp相比具有类似的性能。这些研究结果证实了其作为高性能替代材料的机械可行性，使其更适合于持久的临时修复，特别是在具有高抗应力性、功能习惯或种植体支持的情况下。

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引用次数: 0

Use of colorimetry as a diagnostic tool for early detection of peri-implant diseases 使用比色法作为早期检测种植体周围疾病的诊断工具

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2026-01-20 DOI: 10.1016/j.jobcr.2026.101406

Sergi Torné-Durán

Introduction

The increasing aesthetic demand in dentistry and the limitations of visual colour assessment have encouraged the development of objective methods for evaluating dental and peri-implant tissues. Although colourimeters were originally designed for tooth shade matching, their application has recently expanded to peri-implant soft-tissue analysis, providing quantitative and reproducible measurements capable of detecting early inflammatory changes.

Objectives

This study aimed to determine whether colour analysis using a colourimeter is a valid diagnostic tool for the preliminary detection of peri-implant diseases by comparing colourimetric data with conventional clinical findings.

Materials and methods

A cross-sectional, descriptive, and experimental study was conducted on 63 dental implants. Peri-implant soft-tissue colour was recorded using a colourimeter based on CIELab parameters (L∗, a∗, b∗). Each implant also underwent clinical evaluation including visual inspection, periodontal probing, and periapical radiography. Two measurement points were analysed: Point A, located 2 mm apical to the gingival margin, and Point B, positioned beyond the probing depth for each implant. Colourimetric values from both points were compared with the clinical diagnosis obtained for every implant.

Results

At Point B, peri-implant tissues showed lower luminosity (L∗), higher redness (a∗), and reduced b∗ values compared with Point A. Clinically, 48 implants presented peri-implantitis, 9 mucositis, and 6 were considered healthy. Diseased implants demonstrated darker and more reddish peri-implant tissues, revealing a clear correlation between colour alterations and inflammatory status.

牙科审美需求的增加和视觉颜色评估的局限性鼓励了评估牙齿和种植体周围组织的客观方法的发展。虽然色度计最初是为牙齿色度匹配而设计的，但它们的应用最近已扩展到种植体周围软组织分析，提供能够检测早期炎症变化的定量和可重复测量。目的本研究旨在通过比较比色仪的数据与常规临床表现，确定颜色分析是否是一种有效的诊断工具，用于初步检测种植体周围疾病。材料与方法对63例种植体进行了横断面、描述性和实验性研究。采用基于CIELab参数（L∗,a∗,b∗）的色度计记录种植体周围软组织颜色。每个种植体还进行了临床评估，包括目视检查、牙周探查和根尖周x线摄影。分析了两个测量点：A点位于龈缘顶部2mm处，B点位于每个种植体的探测深度之外。将两个点的比色值与每个种植体的临床诊断结果进行比较。结果B点种植体周围组织亮度（L∗）较a点低，红度（a∗）较高，B∗值降低。临床表现为种植体周围炎48例，黏膜炎9例，健康6例。病变种植体表现为种植体周围组织颜色更深、更红，表明颜色改变与炎症状态之间存在明确的相关性。

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引用次数: 0

In-vitro mechanical performance of three CAD-CAM bar designs for implant-supported metal–resin hybrid prostheses: a preliminary pilot study 三种CAD-CAM杆设计用于种植体支撑的金属-树脂混合假体的体外力学性能：初步试点研究

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2026-01-20 DOI: 10.1016/j.jobcr.2026.101407

Arteaga-Losada Lorena , Laura-Fernadez Héctor , Puerta-Dominguez María Alejandra , Ascaso-Terren Carlos , Vives Eduard , Escuin-Henar Tomás , Torné-Durán Sergi

Background

Implant-supported hybrid metal–resin prostheses are widely used to rehabilitate edentulous patients. However, fractures of the veneering resin and screw complications remain common mechanical failures. Advances in CAD-CAM design and laser sintering technology may improve the structural integrity of these restorations.

Aims

To conduct a preliminary in-vitro evaluation of the fracture resistance of veneering resin in three CAD-CAM–designed bar configurations fabricated by laser sintering, describing their mechanical behavior and failure patterns under compressive stress.

Methods

Three bar designs (inverted T, L-shaped, and Ackerman circular) were digitally created and manufactured in cobalt–chromium using laser sintering. Each bar was veneered with autopolymerizing acrylic resin and subjected to compressive loading up to 1000 N at a 30° angle, in accordance with ISO 14801. Simultaneously, acoustic emission analysis was performed to detect microcracks and structural failures.

Results

No fractures of the veneering resin were observed. Mechanical failures occurred as deformation or fracture of prosthetic screws, beginning at 600 N. Acoustic emission detected early microcracks between 160 N and 400 N, and main fracture peaks between 627 N and 871 N. Among the three samples, the inverted T-shaped bar sustained the highest load before failure in this pilot test.

Conclusion

In this pilot in-vitro study, the veneering resin showed high resistance under simulated masticatory loading. The combination of CAD-CAM design, laser-sintered fabrication, and retentive elements may enhance mechanical performance. Further studies with larger sample sizes and cyclic loading are warranted to validate these preliminary findings.

植物支撑金属-树脂复合修复体广泛应用于无牙患者的修复。然而，贴面树脂骨折和螺钉并发症仍然是常见的机械故障。CAD-CAM设计和激光烧结技术的进步可以提高这些修复体的结构完整性。目的对三种由cad - cam设计的激光烧结棒材中贴面树脂的抗断裂性能进行初步体外评估，描述它们在压应力下的力学行为和破坏模式。方法采用激光烧结技术在钴铬合金中数字化制作3种棒材（倒T形、l形和Ackerman圆形）。每个棒都贴有自聚合丙烯酸树脂，并按照ISO 14801标准，在30°角处承受高达1000 N的压缩载荷。同时，进行声发射分析以检测微裂纹和结构破坏。结果未见贴面树脂断裂。在600 N时，假体螺钉发生变形或断裂，声发射在160 N ~ 400 N之间检测到早期微裂纹，在627 N ~ 871 N之间检测到主要断裂峰。在3个样品中，本次中试中，倒t形杆在失效前承受的载荷最高。结论在体外实验中，贴面树脂在模拟咀嚼负荷下表现出较高的抗咬性能。结合CAD-CAM设计、激光烧结制造和固位元件可以提高机械性能。进一步的研究与更大的样本量和循环加载是必要的，以验证这些初步发现。

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引用次数: 0

Tooth loss among adults with and without presence of systemic diseases – Age and Gender matched case control study 有和不存在全身性疾病的成年人牙齿脱落——年龄和性别匹配的病例对照研究

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2026-01-20 DOI: 10.1016/j.jobcr.2026.01.007

Deshpande Vijaya Lakshmi, S. Jagadeeswara Rao, Dolar Doshi, Twinkle Tiwari, Lunavath Preethi

Background

Systemic diseases contribute to tooth loss by affecting immunity, circulation, and bone health. While most studies focus on elderly, this study assesses tooth loss among adults with and without systemic diseases to support early care.

Aim

To assess tooth loss among adults with and without systemic diseases in age- and gender-matched cases and controls.

Design

A case-control study was conducted among 280 adults (140 cases and 140 controls). Data on demographics, lifestyle factors (alcohol, smoking, oral hygiene), and systemic diseases were collected. Tooth loss was assessed using Tooth Loss Index. Statistical analysis included Chi-square, Mann-Whitney U test, logistic regression, and correlation analysis.

Results

Cases had higher rates of alcohol use, smoking, and poor oral hygiene (p < 0.05). Tooth loss was significantly higher among cases (87.1 %) than controls (50 %), with greater mean missing teeth and higher Tooth Loss Index scores. Low education, alcohol, and smoking were significantly associated with increased tooth loss. Cases had nearly four times higher odds of significant tooth loss (OR = 3.82, p = 0.0001), with a strong positive correlation. (r = 0.82, p = 0.0001).

Conclusion

Systemic diseases are strongly associated with increased tooth loss in adults, highlighting need for early oral health interventions.

背景：全身性疾病通过影响免疫力、血液循环和骨骼健康而导致牙齿脱落。虽然大多数研究都集中在老年人身上，但本研究评估了有和没有全身性疾病的成年人的牙齿脱落情况，以支持早期护理。目的在年龄和性别匹配的病例和对照组中评估有和没有全身性疾病的成年人的牙齿脱落情况。设计对280名成人进行病例对照研究（140例和140例对照）。收集了人口统计学、生活方式因素（酒精、吸烟、口腔卫生）和全身性疾病的数据。采用牙损指数评估牙损情况。统计分析包括卡方检验、Mann-Whitney U检验、logistic回归和相关分析。结果患者饮酒、吸烟、口腔卫生不良发生率较高（p < 0.05）。病例中牙齿脱落率（87.1%）明显高于对照组（50%），平均缺失牙数和牙齿脱落指数得分均较高。受教育程度低、饮酒和吸烟与牙齿脱落的增加显著相关。病例发生明显牙齿脱落的几率高出近4倍（OR = 3.82, p = 0.0001），且呈正相关。（r = 0.82, p = 0.0001）。结论全身性疾病与成人牙齿脱落增加密切相关，强调早期口腔健康干预的必要性。

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引用次数: 0

Comparative analysis between resin-based root canal sealer and recent bioceramic-based root canal sealers using MicroCT, film thickness, and solubility 使用MicroCT、膜厚度和溶解度对树脂基根管密封剂和生物陶瓷基根管密封剂进行比较分析

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2026-01-20 DOI: 10.1016/j.jobcr.2026.01.004

Amira Galal Ismail, Manar M. Galal, Tamer M. Hamdy

Background

This study is aimed at evaluating the sealing quality of the single cone obturation technique with resin-based root canal sealers (ADseal root canal sealers, control group) and the novel hydraulic bioceramic-based sealers (Fill Root ST and AH Plus Bioceramic sealers). The assessment was performed by micro-CT void analysis. In addition, film thickness and solubility of the sealers were also evaluated.

Materials and methods

Voids were evaluated on clear acrylic resin blocks with a standard artificial root canal model using micro-CT. Physical analysis of the sealers assessed film thickness and solubility. Statistical analysis included one-way ANOVA with Tukey's post-hoc test for multiple comparisons and repeated measure ANOVA for related samples.

Results

The AH Plus Bioceramic Sealer exhibited the least canal voids (5.70 %), while the Fill Root ST had intermediate voids, and ADseal had the highest (p < 0.001). The coronal third had the most voids, followed by the middle and apical thirds (p < 0.001). AH Plus Bioceramic Sealer had the thinnest film thickness (19.3 μm), followed by Fill Root ST (42.7 μm), and ADseal (81.7 μm) (p < 0.001). In solubility, ADseal had the lowest (0.9 %), Fill Root ST the highest (2.4 %), and AH Plus Bioceramic intermediate (1.5 %) (p < 0.001).

Conclusions

The bioceramic-based sealers (Fill Root ST and AH Plus Bioceramic) showed superior performance compared to ADseal in terms of void formation and film thickness, with voids most frequent in the coronal third and least in the apical third.

本研究旨在评价树脂根管密封剂（ADseal根管密封剂，对照组）和新型液压生物陶瓷根管密封剂（Fill root ST和AH Plus生物陶瓷根管密封剂）的单锥封闭技术的密封质量。通过微ct空隙分析进行评估。此外，还对密封剂的膜厚和溶解度进行了评价。材料与方法采用micro-CT对透明丙烯酸树脂块与标准人工根管模型的空隙进行评价。封口剂的物理分析评估了薄膜厚度和溶解度。统计分析包括单因素方差分析，采用Tukey事后检验进行多重比较，并对相关样本进行重复测量方差分析。结果AH +生物陶瓷密封器的根管空隙最少（5.70%），充填根管ST为中等空隙，ADseal为最高（p < 0.001）。冠状三分之一有最多的空隙，其次是中间和根尖三分之一（p < 0.001）。AH Plus Bioceramic Sealer的膜厚最薄（19.3 μm），其次是Fill Root ST （42.7 μm）和ADseal (81.7 μm) （p < 0.001）。在溶解度方面，ADseal最低（0.9%），Fill Root ST最高（2.4%），AH Plus生物陶瓷中间体（1.5%）（p < 0.001）。结论生物陶瓷基材（充填根ST和AH +生物陶瓷）在空洞形成和膜厚度方面优于ADseal，空洞在冠状三分之一最常见，在根尖三分之一最少。

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引用次数: 0