Association of HIV infection, other sexually transmitted infections or their coexistence with mpox among men who have sex with men: A national questionnaire-based study in China using propensity score matching
Meihui Zhang , Yuxuan Wang , Yinghuan Zhang , Ying Wang , Jianyu Chen , Gang Xu , Jiechen Zhang , Fan Hu , Yong Cai
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引用次数: 0
Abstract
Background
A marked increase in mpox cases was observed in May 2022 in previously non-endemic regions. The men who have sex with men (MSM) population exhibited a disproportionately higher rate of infection.
Objectives
This study aimed to investigate the coexistence of HIV infection and other sexually transmitted infections (STIs) and their association with mpox among MSM, with validatiton conducted through a case-control study utilizing propensity score matching (PSM).
Methods
A total of 2403 eligible MSM participants were recruited for a cross-sectional study conducted across six geographically representative regions of China from October 2023 to March 2024. Data were collected via an anonymous online questionnaire. Univariable and multivariable logistic regression analyses were performed to evaluate the association between status of HIV infection and other STIs and risk of mpox. Validatiton was conducted through a case-control study employing PSM.
Results
Among the total 2403 participants, 56 (2.33 %) reported diagnosis of mpox. Taking participants negative for both HIV infection and other STIs (group 1) as reference, the adjusted ORs (95 % CIs) (p value) for mpox were 2.00 (0.60–6.65) (p = 0.256), 6.26 (2.97–13.16) (p < 0.001), and 8.72 (3.45–22.00) (p < 0.001) for those who were only positive for HIV infection (group 2), only positive for other STIs (group 3) and positive for both (group 4), respectively. In the case-control study, 53 participants from the mpox group were matched to 149 participants from the non-infection group at a ratio of 1:3. The positive association between status of HIV infection and other STIs and mpox persisted, with adjusted ORs (95 % CIs) (p value) of 1.53 (0.38–6.11) (p = 0.547), 7.01 (3.00–16.38) (p < 0.001), and 6.20 (2.21–17.43) (p < 0.001) for group 2 to group 4, respectively.
Conclusions
This study demonstrated a significant association between other STIs and the risk of mpox among MSM. HIV infection alone didn’t significantly increase the risk of mpox, while other STIs were found to be strong and robust risk factors for mpox.
期刊介绍：
The Journal of Infection and Public Health, first official journal of the Saudi Arabian Ministry of National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences and the Saudi Association for Public Health, aims to be the foremost scientific, peer-reviewed journal encompassing infection prevention and control, microbiology, infectious diseases, public health and the application of healthcare epidemiology to the evaluation of health outcomes. The point of view of the journal is that infection and public health are closely intertwined and that advances in one area will have positive consequences on the other.
The journal will be useful to all health professionals who are partners in the management of patients with communicable diseases, keeping them up to date. The journal is proud to have an international and diverse editorial board that will assist and facilitate the publication of articles that reflect a global view on infection control and public health, as well as emphasizing our focus on supporting the needs of public health practitioners.
It is our aim to improve healthcare by reducing risk of infection and related adverse outcomes by critical review, selection, and dissemination of new and relevant information in the field of infection control, public health and infectious diseases in all healthcare settings and the community.
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