Valoración de dos biomarcadores inmunológicos en sepsis bacteriana y shock séptico

Abstract

Introduction

Sepsis is a disorder that can progress to shock, with multiple organ failure and increased mortality, so the study of inflammation biomarkers can help prevent these complications.

Objective

Establish an association between serum concentrations of the biomarkers LPS and MyD88 with bacterial sepsis and progression to shock.

Methods

A cross-sectional analytical study was carried out, using a cohort of septic adult patients with Gram-negative bacterial etiology and with progression to shock, of any gender and socioeconomic condition, in whom serum concentrations of the biomarkers LPS and MyD88 were established by enzyme immunoassay.

Results

LPS serum concentrations in patients with septic shock (n = 50) were mean ± SD: 31.86 ± 11.4 ng/mL; and septic patients without progress to shock (n = 75), the results were 24.7 ± 13.6 ng/mL (p = 0.010).; while those found for MyD88 in patients with septic shock (n = 50) were mean ± SD: 3267.2 ± 2001.5 pg/mL and septic patients without progression to shock (n = 75) were 2178.3 ± 2948.9 pg/mL (p = 0.004).

Conclusion

An association was obtained between the serum levels of the biomarkers LPS and MyD88, both in patients with bacterial sepsis without progression to shock, and in those who progressed to this condition.