Clerochinoids A‒H, aromatic abietane diterpenoids with cytotoxic activity from the roots and stems of Clerodendrum chinense

IF 3.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Phytochemistry Pub Date : 2025-03-10 DOI:10.1016/j.phytochem.2025.114474

Jieting Chen , Zhilong Liu , Yuepei Huang , Yushi Huang , Lihua Peng , Weilin Qiao , Wei Li , De-an Guo

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引用次数: 0

Abstract

Eight previously undescribed aromatic abietane diterpenoids, clerochinoids A−H (1–8), including seven 17(15 → 16)-abeo-abietanes (1–7) and one 17(15 → 16),18(4 → 3)-diabeo-abietane (8), along with 12 known analogues (9–20) were isolated from the roots and stems of Clerodendrum chinense. Their structures were elucidated by extensive spectroscopic data analysis, X-ray crystallography, and ECD calculations. All the compounds were screened for their cytotoxic activity against two human non-small cell lung cancer cell lines, H1975 and HCC827. Compounds 3, 9, 10, 12−14, 16, 17, 18, and 20 exhibited enhanced activity compared to the positive control, gefitinib. The succinct structure−activity relationship of these abietane diterpenoids was also discussed.

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来源期刊

Phytochemistry 生物-植物科学

CiteScore

6.40

自引率

7.90%

发文量

443

审稿时长

39 days

期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.