A Cross-Sectional Comparative Study: Could Asprosin and Peptide Tyrosine-Tyrosine Be Used in Schizophrenia to Define the Disease and Determine Its Phases?

IF 3 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Diagnostics Pub Date : 2025-03-05 DOI:10.3390/diagnostics15050632
Elif Özcan Tozoğlu, Nilifer Gürbüzer, Alev Lazoğlu Özkaya, Sümeyya Akyıldırım
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Abstract

Background/Objectives: We aimed to evaluate asprosin and peptide tyrosine-tyrosine (PYY) levels in schizophrenia patients and the relationships between these levels and clinical severity, as well as whether these two hormones have a role in determining the disease and/or the phases of the disease. Methods: This study included 50 patients with schizophrenia in the remission phase, 50 in the acute phase, and 50 controls. The Positive and Negative Syndrome Scale (PANSS) was filled out for patients. The patients' biochemical parameters and asprosin and PYY levels were measured. Results: Levels of asprosin and PYY were significantly different in all three groups (p < 0.001, p < 0.001). In the remission phase group, asprosin levels had a negative effect on PANSS general symptomatology scores (p: 0.002, p < 0.001). In the acute phase group, while PYY levels showed a negative effect on PANSS general symptomatology scores (p: 0.031), asprosin levels had a negative effect on all subscales of PANSS (p < 0.001). In the acute phase, a one-unit decrease in asprosin levels was associated with a 93% increase in PANSS total scores. The results of the receiver operating characteristic (ROC) analysis to distinguish the acute phase showed that PYY could not be used for diagnosis (p: 0.066), but asprosin was associated with the acute phase of schizophrenia (p < 0.001) and both asprosin and PYY were associated with the disease (p < 0.001, p < 0.001). Conclusions: We think that both asprosin and PYY can be used as potential biomarkers to identify schizophrenia, and only asprosin to identify the phases of the disease. PYY and asprosin levels may be markers that can be used to determine clinical severity.

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背景/目的:我们的目的是评估精神分裂症患者体内的天冬氨酸和肽酪氨酸(PYY)水平,以及这些水平与临床严重程度之间的关系,同时评估这两种激素是否在决定疾病和/或疾病阶段方面发挥作用。研究方法这项研究包括 50 名处于缓解期的精神分裂症患者、50 名处于急性期的精神分裂症患者和 50 名对照组患者。患者填写阳性和阴性综合征量表(PANSS)。对患者的生化指标以及天冬氨酸和PYY水平进行了测量。结果显示三组患者的天冬氨酸和PYY水平均有显著差异(P < 0.001,P < 0.001)。在缓解期组,天冬氨酸水平对 PANSS 一般症状评分有负面影响(p: 0.002, p < 0.001)。在急性期组,虽然PYY水平对PANSS一般症状评分有负面影响(p:0.031),但阿司匹林水平对PANSS的所有分量表都有负面影响(p<0.001)。在急性期,阿司匹林水平每降低一个单位,PANSS 总分就会增加 93%。区分急性期的接收器操作特征(ROC)分析结果显示,PYY不能用于诊断(p:0.066),但asprosin与精神分裂症急性期相关(p < 0.001),asprosin和PYY均与疾病相关(p < 0.001,p < 0.001)。结论我们认为,asprosin 和 PYY 都可作为识别精神分裂症的潜在生物标记物,而只有 asprosin 可用于识别疾病的阶段。PYY和asprosin水平可能是用于确定临床严重程度的标志物。
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来源期刊
Diagnostics
Diagnostics Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry
CiteScore
4.70
自引率
8.30%
发文量
2699
审稿时长
19.64 days
期刊介绍: Diagnostics (ISSN 2075-4418) is an international scholarly open access journal on medical diagnostics. It publishes original research articles, reviews, communications and short notes on the research and development of medical diagnostics. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental and/or methodological details must be provided for research articles.
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