Radiofrequency Echographic Multi Spectrometry-A Novel Tool in the Diagnosis of Osteoporosis and Prediction of Fragility Fractures: A Systematic Review.

IF 3 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Diagnostics Pub Date : 2025-02-25 DOI:10.3390/diagnostics15050555
Elena Icătoiu, Andreea-Iulia Vlădulescu-Trandafir, Laura-Maria Groșeanu, Florian Berghea, Claudia-Oana Cobilinschi, Claudia-Gabriela Potcovaru, Andra-Rodica Bălănescu, Violeta-Claudia Bojincă
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Abstract

Background/Objectives: Given the significant economic and social burden of osteoporosis, there is growing interest in developing an efficient alternative to the traditional dual-energy X-ray absorptiometry (DXA). Radiofrequency Echographic Multi Spectrometry (REMS) is an innovative, non-ionizing imaging technique that recently emerged as a viable tool to diagnose osteoporosis and estimate the fragility fracture risk. Nevertheless, its clinical use is still limited due to its novelty and continuing uncertainty of long-term performance. Methods: In order to evaluate the accuracy of the REMS, a systematic review of the English-language literature was conducted. Three databases were searched for relevant publications from 1 January 2015 until 1 December 2024 using the keyword combinations "(radiofrequency echographic multi spectrometry OR REMS) AND (dual-energy X-ray absorptiometry OR DXA)". The initial search yielded 602 candidate articles. After screening the titles and abstracts following the eligibility criteria, 17 publications remained for full-text evaluation. Results: The reviewed studies demonstrated strong diagnostic agreement between REMS and DXA. Additionally, REMS showed enhanced diagnostic capabilities in cases where lumbar bone mineral density measurements by DXA were impaired by artifacts such as vertebral fractures, deformities, osteoarthritis, or vascular calcifications. REMS exhibited excellent intra-operator repeatability and precision, comparable to or exceeding the reported performance of DXA. The fragility score (FS), a parameter reflecting bone quality and structural integrity, effectively discriminated between fractured and non-fractured patients. Moreover, REMS proved to be a radiation-free option for bone health monitoring in radiation-sensitive populations or patients requiring frequent imaging to assess fracture risk. Conclusions: This current study underscores the robustness of REMS as a reliable method for diagnosing and monitoring osteoporosis and evaluating bone fragility via the FS. It also identifies critical knowledge gaps and emphasizes the need for further prospective studies to validate and expand the clinical applications of REMS across diverse patient populations.

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背景/目标:鉴于骨质疏松症造成的巨大经济和社会负担,人们对开发传统双能 X 射线吸收测量法 (DXA) 的高效替代方法越来越感兴趣。射频回声多谱仪(REMS)是一种创新的非电离成像技术,最近已成为诊断骨质疏松症和估算脆性骨折风险的可行工具。然而,由于其新颖性和长期性能的不确定性,其临床应用仍然有限。方法:为了评估 REMS 的准确性,我们对英文文献进行了系统性回顾。使用关键词组合"(射频回波多谱勒或 REMS)和(双能 X 射线吸收测量或 DXA)"检索了三个数据库中 2015 年 1 月 1 日至 2024 年 12 月 1 日期间的相关出版物。初步搜索结果为 602 篇候选文章。按照资格标准对标题和摘要进行筛选后,剩下 17 篇文章进行全文评估。结果:经审查的研究表明,REMS 和 DXA 在诊断方面具有很强的一致性。此外,当 DXA 测量的腰椎骨矿物质密度受到椎体骨折、畸形、骨关节炎或血管钙化等伪影的影响时,REMS 显示出更强的诊断能力。REMS 显示出极佳的术者内可重复性和精确性,可媲美或超过已报道的 DXA 性能。脆性评分(FS)是反映骨骼质量和结构完整性的参数,它能有效区分骨折和非骨折患者。此外,对于辐射敏感人群或需要频繁进行成像以评估骨折风险的患者,REMS 被证明是一种无辐射的骨健康监测选择。结论:目前的这项研究强调了 REMS 作为诊断和监测骨质疏松症以及通过 FS 评估骨脆性的可靠方法的稳健性。研究还发现了一些关键的知识空白,并强调有必要进一步开展前瞻性研究,以验证和扩大 REMS 在不同患者群体中的临床应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Diagnostics
Diagnostics Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry
CiteScore
4.70
自引率
8.30%
发文量
2699
审稿时长
19.64 days
期刊介绍: Diagnostics (ISSN 2075-4418) is an international scholarly open access journal on medical diagnostics. It publishes original research articles, reviews, communications and short notes on the research and development of medical diagnostics. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental and/or methodological details must be provided for research articles.
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