Contraceptive use, both oral and parenteral, is associated with increased arterial stiffness in young healthy women.

IF 3.7 3区 医学 Q2 Medicine Endocrine Pub Date : 2025-03-13 DOI:10.1007/s12020-025-04208-9
Paul Pettersson-Pablo, Torbjörn K Nilsson, Anita Hurtig-Wennlöf
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Abstract

Purpose: Previous studies on the impact on arterial health of contraceptive use, or across the menstrual phases, have yielded differing results. Furthermore, there is little research on the differences based on the delivery method of the contraceptive, oral vs parenteral contraceptives. In this study, we examined arterial health using three different physiological measures of arterial function and structure in contraceptive users and non-users.

Methods: Young, healthy women, between 18.0-25.9 years of age were enrolled in the study (n = 577). Menstrual phase and contraceptive use and type were assessed by questionnaire. Arterial stiffness was measured using pulse-wave velocity (PWV) and augmentation index (AIx). Arterial thickness was measured using carotid-intima media thickness (cIMT). Blood samples were analysed for various biomarkers, which were used in multivariate regressions to adjust for the effects of contraceptive use on vascular status.

Results: Contraceptive users had a higher PWV than non-users. The menstrual phase did not impact PWV. In a smaller subgroup analysis, comparing the types of contraceptives, oral or parenteral, did not impact PWV. AIx and cIMT did not differ significantly between any studied groups. Systolic blood pressure, BMI, serum lipids, C-reactive protein, and sex hormone binding globulin concentrations were higher in the contraceptive using group, but in multivariable models, these biomarkers had only limited impact on the association between contraceptive use and PWV.

Conclusion: In a population of young, healthy women, contraceptive users displayed higher PWV values. The effect could not be explained by the effect of contraceptives on androgenicity, blood pressure or lipids.

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目的:以往关于使用避孕药对动脉健康的影响或不同月经期避孕药对动脉健康的影响的研究得出了不同的结果。此外,关于避孕药的给药方式(口服避孕药和肠外避孕药)的差异研究也很少。在这项研究中,我们使用三种不同的生理测量方法来检测避孕药使用者和非使用者的动脉功能和结构,从而了解她们的动脉健康状况:研究对象为年龄在 18.0-25.9 岁之间的年轻健康女性(n = 577)。通过问卷对月经期、避孕药的使用和类型进行评估。动脉僵硬度通过脉搏波速度(PWV)和增强指数(AIx)进行测量。动脉厚度采用颈动脉内膜厚度(cIMT)进行测量。对血液样本中的各种生物标志物进行分析,并将其用于多变量回归,以调整使用避孕药对血管状况的影响:结果:避孕药使用者的脉搏波速度高于非避孕药使用者。月经期对脉搏波速度没有影响。在一个较小的亚组分析中,比较口服或肠道外避孕药的类型对脉搏波速度没有影响。各研究组的 AIx 和 cIMT 均无显著差异。使用避孕药组的收缩压、体重指数、血脂、C反应蛋白和性激素结合球蛋白浓度较高,但在多变量模型中,这些生物标志物对使用避孕药与脉搏波速度之间的关系影响有限:结论:在年轻、健康的女性人群中,避孕药使用者的脉搏波速度值更高。结论:在一个年轻、健康的女性群体中,避孕药使用者的脉搏波速度值较高,而避孕药对雄激素、血压或血脂的影响无法解释这种效应。
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来源期刊
Endocrine
Endocrine 医学-内分泌学与代谢
CiteScore
6.40
自引率
5.40%
发文量
0
期刊介绍: Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.
期刊最新文献
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