Association Between Progesterone Level on Trigger Day to Basal Progesterone Ratio and in vitro Fertilization-Embryo Transfer Outcomes in Antagonist Protocols.

IF 2.5 4区 医学 Q2 OBSTETRICS & GYNECOLOGY International Journal of Women's Health Pub Date : 2025-03-08 eCollection Date: 2025-01-01 DOI:10.2147/IJWH.S506574
Miao-Yi Xu, Yu-Ting Wang, Yao-Fang Liu
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Abstract

Objective: To investigate the relationship between the progesterone level on trigger day (Ptrigger) to basal progesterone (bP) ratio and the outcomes of in vitro fertilization-embryo transfer (IVF-ET).

Methods: A retrospective analysis was conducted on women who received an antagonist protocol, with a Ptrigger less than 1.5 ng/mL and who underwent fresh embryo transfer. Based on the Ptrigger/bP ratio, participants were categorized into four groups: group A (Ptrigger/bP < 1, n = 284), group B (Ptrigger/bP ≥ 1 and < 2, n = 363), group C (Ptrigger/bP ≥ 2 and < 3, n = 165), and group D (Ptrigger/bP ≥ 3, n = 118). Recombinant follicle-stimulating hormone was used to stimulate ovulation. Receiver operating characteristic curve analysis was used to analyze the accuracy of the Ptrigger/bP ratio in predicting clinical pregnancy following fresh embryo transfer.

Results: A decreasing trend in bP levels was observed across groups (A > B > C > D), while Ptrigger levels showed an increasing trend (A < B < C < D). Groups A and B included significantly younger women and required lower doses of gonadotropin (Gn) compared to Groups C and D. The embryo implantation and clinical pregnancy rates in Group A were 34.93% and 49.30%, respectively, significantly higher than those in Group D (23.19% and 33.90%, respectively). After propensity score matching for age, the differences in implantation and clinical pregnancy rates were not statistically significant between Group A and D. The Ptrigger/bP ratio had limited accuracy in predicting clinical pregnancy, with an area under the curve of 0.538 (95% CI [confidence interval]: 0.501-0.575, P = 0.044).

Conclusion: A Ptrigger/bP ratio of less than 1 was associated with relatively favorable pregnancy outcomes in women undergoing IVF-ET with an antagonist protocol for ovulation induction.

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来源期刊
International Journal of Women's Health
International Journal of Women's Health OBSTETRICS & GYNECOLOGY-
CiteScore
3.70
自引率
0.00%
发文量
194
审稿时长
16 weeks
期刊介绍: International Journal of Women''s Health is an international, peer-reviewed, open access, online journal. Publishing original research, reports, editorials, reviews and commentaries on all aspects of women''s healthcare including gynecology, obstetrics, and breast cancer. Subject areas include: Chronic conditions including cancers of various organs specific and not specific to women Migraine, headaches, arthritis, osteoporosis Endocrine and autoimmune syndromes - asthma, multiple sclerosis, lupus, diabetes Sexual and reproductive health including fertility patterns and emerging technologies to address infertility Infectious disease with chronic sequelae including HIV/AIDS, HPV, PID, and other STDs Psychological and psychosocial conditions - depression across the life span, substance abuse, domestic violence Health maintenance among aging females - factors affecting the quality of life including physical, social and mental issues Avenues for health promotion and disease prevention across the life span Male vs female incidence comparisons for conditions that affect both genders.
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