Regional variations in corneal oedema during open-eye fenestrated scleral lens wear.

IF 2.8 3区 医学 Q1 OPHTHALMOLOGY Ophthalmic and Physiological Optics Pub Date : 2025-03-13 DOI:10.1111/opo.13489
Asif Iqbal, Damien Fisher, David Alonso-Caneiro, Michael J Collins, Stephen J Vincent
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引用次数: 0

Abstract

Purpose: To compare the magnitude of central, mid-peripheral and peripheral stromal corneal oedema induced during short-term fenestrated and non-fenestrated scleral lens wear.

Methods: Nine healthy participants wore a non-fenestrated and a fenestrated (0.3-mm diameter limbal fenestration) scleral lens (KATT™, Capricornia Contact Lenses), hexafocon B material (Dk 141 × 10-11 cm3 O2(cm)/[(s) (cm2) (mmHg)]) in one eye under open-eye conditions for 90 min on two separate days. Scleral lens thickness, fluid reservoir thickness and stromal corneal oedema were measured using high-resolution optical coherence tomography. Stromal oedema was quantified across the central (0-2.5 mm from the corneal apex), mid-peripheral (-3.0 to -1.0 mm from the scleral spur) and peripheral (-1.0 to 0 mm from the scleral spur) cornea with the lens in situ. The magnitude of oedema was corrected based on variations in fluid reservoir thickness between the lens conditions.

Results: There was a significant effect of lens type (p = 0.04) on stromal oedema, with less oedema observed with the fenestrated (0.36 ± 0.45%) compared to the non-fenestrated lenses (1.24 ± 0.27%), averaged across all corneal locations. A significant lens type by corneal location interaction was also observed (p = 0.05), with less oedema observed in the peripheral region for the fenestrated (-0.15 ± 0.98%) compared to the non-fenestrated lenses (1.81 ± 0.57%) (p = 0.048). A fenestration location by corneal location interaction was also observed (p = 0.02), indicating a greater reduction in oedema closer to the fenestration.

Conclusions: Central and mid-peripheral stromal oedema was similar during fenestrated and non-fenestrated lens wear; however, fenestrated lenses displayed significantly less oedema in the peripheral cornea. This is most likely due to increased oxygen delivery in proximity to the fenestration.

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来源期刊
CiteScore
5.10
自引率
13.80%
发文量
135
审稿时长
6-12 weeks
期刊介绍: Ophthalmic & Physiological Optics, first published in 1925, is a leading international interdisciplinary journal that addresses basic and applied questions pertinent to contemporary research in vision science and optometry. OPO publishes original research papers, technical notes, reviews and letters and will interest researchers, educators and clinicians concerned with the development, use and restoration of vision.
期刊最新文献
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