{"title":"E-Cadherin is a diagnostic biomarker in the progression of oral epithelial dysplasia to squamous cell carcinoma","authors":"Dhanusree Kani , Vindhya Savithri , Rakesh Suresh , Ramanarayanan Venkitachalam , Mahija Janardhanan , Thara Aravind","doi":"10.1016/j.jobcr.2025.02.015","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Oral squamous cell carcinoma is a common cancer of head and neck region with poor prognosis and may sometimes show a premalignant stage. Cell-cell adhesion molecules play an important role in the process of malignant transformation. E-cadherin, a cell-to-cell adhesion molecule, plays a crucial role in maintaining cell polarity and adhesion of epithelial cells.</div></div><div><h3>Aims</h3><div>To assess the expression of E-cadherin in various grades of oral epithelial dysplasia and oral squamous cells carcinoma and compare it to unremarkable oral mucosa.</div></div><div><h3>Materials and methods</h3><div>The study comprised a total sample size of 80 with 10 cases of unremarkable oral mucosa which is the control group, 40 cases of oral epithelial dysplasia and 30 cases of oral squamous cell carcinoma. One section was stained with haematoxylin and eosin to confirm the histopathological diagnosis and other section was stained immunohistochemically with E-cadherin.</div></div><div><h3>Results</h3><div>The study found that E-cadherin expression was strongly positive in unremarkable mucosal epithelium, reduced in oral epithelial dysplasia, and gradually decreased as it progressed to oral squamous cell carcinoma. These findings were found to be statistically significant.</div></div><div><h3>Conclusion</h3><div>The study found a correlation between E-cadherin expression loss and oral squamous cell carcinoma progression, suggesting that E-cadherin can serve as a diagnostic biomarker for malignant transformation of oral epithelial dysplasia and predict disease prognosis in oral squamous cell carcinoma.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 3","pages":"Pages 508-514"},"PeriodicalIF":0.0000,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of oral biology and craniofacial research","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2212426825000569","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Background
Oral squamous cell carcinoma is a common cancer of head and neck region with poor prognosis and may sometimes show a premalignant stage. Cell-cell adhesion molecules play an important role in the process of malignant transformation. E-cadherin, a cell-to-cell adhesion molecule, plays a crucial role in maintaining cell polarity and adhesion of epithelial cells.
Aims
To assess the expression of E-cadherin in various grades of oral epithelial dysplasia and oral squamous cells carcinoma and compare it to unremarkable oral mucosa.
Materials and methods
The study comprised a total sample size of 80 with 10 cases of unremarkable oral mucosa which is the control group, 40 cases of oral epithelial dysplasia and 30 cases of oral squamous cell carcinoma. One section was stained with haematoxylin and eosin to confirm the histopathological diagnosis and other section was stained immunohistochemically with E-cadherin.
Results
The study found that E-cadherin expression was strongly positive in unremarkable mucosal epithelium, reduced in oral epithelial dysplasia, and gradually decreased as it progressed to oral squamous cell carcinoma. These findings were found to be statistically significant.
Conclusion
The study found a correlation between E-cadherin expression loss and oral squamous cell carcinoma progression, suggesting that E-cadherin can serve as a diagnostic biomarker for malignant transformation of oral epithelial dysplasia and predict disease prognosis in oral squamous cell carcinoma.
期刊介绍：
Journal of Oral Biology and Craniofacial Research (JOBCR)is the official journal of the Craniofacial Research Foundation (CRF). The journal aims to provide a common platform for both clinical and translational research and to promote interdisciplinary sciences in craniofacial region. JOBCR publishes content that includes diseases, injuries and defects in the head, neck, face, jaws and the hard and soft tissues of the mouth and jaws and face region; diagnosis and medical management of diseases specific to the orofacial tissues and of oral manifestations of systemic diseases; studies on identifying populations at risk of oral disease or in need of specific care, and comparing regional, environmental, social, and access similarities and differences in dental care between populations; diseases of the mouth and related structures like salivary glands, temporomandibular joints, facial muscles and perioral skin; biomedical engineering, tissue engineering and stem cells. The journal publishes reviews, commentaries, peer-reviewed original research articles, short communication, and case reports.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
