Toxoplasmosis infection and schizophrenia: Elevated IgM reactivity index as a predictor of symptom worsening in chronic schizophrenia

IF 3.6 2区 医学 Q1 PSYCHIATRY Schizophrenia Research Pub Date : 2025-03-14 DOI:10.1016/j.schres.2025.03.008
Pedro H.P. Alvim , Victoria C. Cavalari , Ana J. Bianchini , Gabriela Ferreira Frizon , Gabriela Mourao Ferreira , Helena Fabiane Huth Savian , Isabela Drehmer , Jéferson Ferraz Goularte , Luiz F.C. Garcia , Marcelo Carriello , Mariane Noto , Monise Costanzi , Rafael Amaral Donassolo , Vanessa Ota , Vitória G. Berlitz , Cristiano Noto , Sintia Belangero , Ary Gadelha , Clarissa S. Gama , Letusa Albrecht , Raffael Massuda
{"title":"Toxoplasmosis infection and schizophrenia: Elevated IgM reactivity index as a predictor of symptom worsening in chronic schizophrenia","authors":"Pedro H.P. Alvim ,&nbsp;Victoria C. Cavalari ,&nbsp;Ana J. Bianchini ,&nbsp;Gabriela Ferreira Frizon ,&nbsp;Gabriela Mourao Ferreira ,&nbsp;Helena Fabiane Huth Savian ,&nbsp;Isabela Drehmer ,&nbsp;Jéferson Ferraz Goularte ,&nbsp;Luiz F.C. Garcia ,&nbsp;Marcelo Carriello ,&nbsp;Mariane Noto ,&nbsp;Monise Costanzi ,&nbsp;Rafael Amaral Donassolo ,&nbsp;Vanessa Ota ,&nbsp;Vitória G. Berlitz ,&nbsp;Cristiano Noto ,&nbsp;Sintia Belangero ,&nbsp;Ary Gadelha ,&nbsp;Clarissa S. Gama ,&nbsp;Letusa Albrecht ,&nbsp;Raffael Massuda","doi":"10.1016/j.schres.2025.03.008","DOIUrl":null,"url":null,"abstract":"<div><div>The association between schizophrenia and toxoplasmosis has been studied for decades; however, most studies have small sample sizes, and few have investigated the relationship between toxoplasmosis and schizophrenia symptoms. This study aimed to compare the prevalence of toxoplasmosis seropositivity between schizophrenia patients and healthy controls in a large Brazilian sample and to investigate the association between IgM and IgG reactivity index (RI) and the severity of schizophrenia symptoms. A multicenter, cross-sectional study assessed Positive and Negative Symptoms Scale from patients, seropositivity to toxoplasmosis as well as serointensity (RI) of IgM and IgG from blood samples of 705 subjects: 313 healthy controls and 392 schizophrenia patients (313 chronic patients and 76 first episode of psychosis). The prevalence of seropositivity to toxoplasmosis was higher in schizophrenia than in controls (OR of 1.52, 95 % CI 1.11–2.07, <em>p</em> = .008), especially in those in FEP (OR = 1.99, 95 % CI 1.02–2.97, <em>p</em> = .042). Also, IgM RI was positively associated with the PANSS total (<em>p</em> = .012, R<sup>2</sup> = 0.17), positive (<em>p</em> = .017, R<sup>2</sup> = 0.17), and general scores (<em>p</em> = .018, R<sup>2</sup> = 0.14) in chronic patients. Toxoplasmosis is associated with schizophrenia, especially in patients in their first psychotic episode; moreover, RI of IgM was positively associated with the severity of the psychosis in chronic patients, which suggests that new infection may worsen symptomatology.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"278 ","pages":"Pages 20-25"},"PeriodicalIF":3.6000,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Schizophrenia Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0920996425000696","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
引用次数: 0

Abstract

The association between schizophrenia and toxoplasmosis has been studied for decades; however, most studies have small sample sizes, and few have investigated the relationship between toxoplasmosis and schizophrenia symptoms. This study aimed to compare the prevalence of toxoplasmosis seropositivity between schizophrenia patients and healthy controls in a large Brazilian sample and to investigate the association between IgM and IgG reactivity index (RI) and the severity of schizophrenia symptoms. A multicenter, cross-sectional study assessed Positive and Negative Symptoms Scale from patients, seropositivity to toxoplasmosis as well as serointensity (RI) of IgM and IgG from blood samples of 705 subjects: 313 healthy controls and 392 schizophrenia patients (313 chronic patients and 76 first episode of psychosis). The prevalence of seropositivity to toxoplasmosis was higher in schizophrenia than in controls (OR of 1.52, 95 % CI 1.11–2.07, p = .008), especially in those in FEP (OR = 1.99, 95 % CI 1.02–2.97, p = .042). Also, IgM RI was positively associated with the PANSS total (p = .012, R2 = 0.17), positive (p = .017, R2 = 0.17), and general scores (p = .018, R2 = 0.14) in chronic patients. Toxoplasmosis is associated with schizophrenia, especially in patients in their first psychotic episode; moreover, RI of IgM was positively associated with the severity of the psychosis in chronic patients, which suggests that new infection may worsen symptomatology.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
求助全文
约1分钟内获得全文 去求助
来源期刊
Schizophrenia Research
Schizophrenia Research 医学-精神病学
CiteScore
7.50
自引率
8.90%
发文量
429
审稿时长
10.2 weeks
期刊介绍: As official journal of the Schizophrenia International Research Society (SIRS) Schizophrenia Research is THE journal of choice for international researchers and clinicians to share their work with the global schizophrenia research community. More than 6000 institutes have online or print (or both) access to this journal - the largest specialist journal in the field, with the largest readership! Schizophrenia Research''s time to first decision is as fast as 6 weeks and its publishing speed is as fast as 4 weeks until online publication (corrected proof/Article in Press) after acceptance and 14 weeks from acceptance until publication in a printed issue. The journal publishes novel papers that really contribute to understanding the biology and treatment of schizophrenic disorders; Schizophrenia Research brings together biological, clinical and psychological research in order to stimulate the synthesis of findings from all disciplines involved in improving patient outcomes in schizophrenia.
期刊最新文献
Toxoplasmosis infection and schizophrenia: Elevated IgM reactivity index as a predictor of symptom worsening in chronic schizophrenia Brief video intervention to reduce stigma of family and friends of people living with serious mental illness LEPR gene polymorphisms and pneumonia risk in Taiwanese schizophrenia patients under clozapine treatment Prediction of treatment response in drug-naïve schizophrenia patients from the perspective of targeted metabolomics Effects of visual remediation on Ebbinghaus illusion task performance in people with schizophrenia: A preliminary study
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1