Pub Date : 2025-03-01DOI: 10.1016/j.schres.2025.02.011
Kaitlyn A. Kaiser , Judy L. Thompson , Pamela D. Butler , Anthony O. Ahmed , Aaron R. Seitz , Tarek Sobeih , Steven M. Silverstein
Background
Atypical perception of visual illusions is well-documented in schizophrenia (SZ) and thought to be a consequence of impairments in visual processes including perceptual organization (PO). The Ebbinghaus illusion, in which a circle appears larger or smaller depending on the size of surrounding circles, is facilitated by PO, and the extent to which the surrounds (i.e., context) influence perception of the center circle can be considered an index of context sensitivity. In the present study, as part of a broader investigation of the impact of a novel visual remediation (VR) program for people with SZ, the Ebbinghaus illusion was used to explore the effects of VR on context sensitivity.
Methods
Participants with SZ (n = 47) were randomly assigned to one of four conditions: VR only, an active control condition (AC), or one of two conditions combining VR and AC. At three assessment points, participants completed a size comparison task based on the Ebbinghaus illusion. Context sensitivity was compared between training groups and with baseline clinical characteristics.
Results
At baseline, participants were strongly context sensitive. After training, participants in the VR group, but not the AC-only group, became less influenced by context. The main effect of training group and the group × time interaction terms were not significant. Participants who were less symptomatic at baseline showed the greatest reductions in context sensitivity over time.
Conclusions
These findings suggest that an adaptive reduction in the influence of irrelevant context is a potential effect of VR and may reflect improved attentional focus.
{"title":"Effects of visual remediation on Ebbinghaus illusion task performance in people with schizophrenia: A preliminary study","authors":"Kaitlyn A. Kaiser , Judy L. Thompson , Pamela D. Butler , Anthony O. Ahmed , Aaron R. Seitz , Tarek Sobeih , Steven M. Silverstein","doi":"10.1016/j.schres.2025.02.011","DOIUrl":"10.1016/j.schres.2025.02.011","url":null,"abstract":"<div><h3>Background</h3><div>Atypical perception of visual illusions is well-documented in schizophrenia (SZ) and thought to be a consequence of impairments in visual processes including perceptual organization (PO). The Ebbinghaus illusion, in which a circle appears larger or smaller depending on the size of surrounding circles, is facilitated by PO, and the extent to which the surrounds (i.e., context) influence perception of the center circle can be considered an index of <em>context sensitivity</em>. In the present study, as part of a broader investigation of the impact of a novel visual remediation (VR) program for people with SZ, the Ebbinghaus illusion was used to explore the effects of VR on context sensitivity.</div></div><div><h3>Methods</h3><div>Participants with SZ (<em>n</em> = 47) were randomly assigned to one of four conditions: VR only, an active control condition (AC), or one of two conditions combining VR and AC. At three assessment points, participants completed a size comparison task based on the Ebbinghaus illusion. Context sensitivity was compared between training groups and with baseline clinical characteristics.</div></div><div><h3>Results</h3><div>At baseline, participants were strongly context sensitive. After training, participants in the VR group, but not the AC-only group, became less influenced by context. The main effect of training group and the group × time interaction terms were not significant. Participants who were less symptomatic at baseline showed the greatest reductions in context sensitivity over time.</div></div><div><h3>Conclusions</h3><div>These findings suggest that an adaptive reduction in the influence of irrelevant context is a potential effect of VR and may reflect improved attentional focus.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"277 ","pages":"Pages 57-64"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01DOI: 10.1016/j.schres.2025.02.015
Daniel Kamp , Agnes Lowe , Karolin Weide , Mathias Riesbeck , Andreas Bechdolf , Karolina Leopold , Anke Brockhaus-Dumke , Bettina Klos , René Hurlemann , Sven Wasserthal , Ana Muthesius , Joseph Kambeitz , Stefan Klingberg , Lea Hölz , Martin Hellmich , Kerstin D. Rosenberger , Sabine Sadura , Andreas Meyer-Lindenberg , Wolfgang Wölwer
Introduction
Persistent poor psychosocial functioning, which is associated with impairments in cognition, is one of the main barriers to recovery in schizophrenia. Although cognitive remediation therapy (CRT) has shown general efficacy in improving cognition and functioning, simultaneously focusing on social cognition and social behavioural processes may increase its efficacy.
Methods
In a multicenter, rater-blinded, randomized controlled trial, schizophrenia patients (N = 177) were assigned to six months of either Integrated Social Cognitive and Behavioral Skills Therapy (ISST) or, as an active control intervention, Neurocognitive Remediation Therapy (NCRT). The primary endpoint was all-cause discontinuation (ACD) over the 12-month study period. Secondary endpoints were cognition, psychosocial functioning and quality of life, and clinical symptoms.
Results
ACD was not significantly different between the ISST and NCRT groups (43.3 % vs 34.5 %, respectively). More improvement was seen in social cognition (Pictures of Facial Affect; d = 0.83) in the ISST group and in neurocognition (subscores of the Auditory Verbal Learning Test; d = 0.29–0.40) in the NCRT group. Level of functioning, quality of life, and clinical symptoms significantly improved in both groups, with no significant between-group differences.
Discussion
Both therapies differentially improved measures of the cognitive domains they were designed for. Moreover, they both improved social functioning with high effect sizes (d = 0.8–1.0), underlining the important role of CRT in recovery-oriented schizophrenia treatment. However, the absence of a third group without an active intervention limits the interpretability of the results.
{"title":"Efficacy of integrated social cognitive remediation vs neurocognitive remediation in schizophrenia: Results from the multicenter randomized controlled ISST (Integrated Social Cognition And Social Skills Therapy) study","authors":"Daniel Kamp , Agnes Lowe , Karolin Weide , Mathias Riesbeck , Andreas Bechdolf , Karolina Leopold , Anke Brockhaus-Dumke , Bettina Klos , René Hurlemann , Sven Wasserthal , Ana Muthesius , Joseph Kambeitz , Stefan Klingberg , Lea Hölz , Martin Hellmich , Kerstin D. Rosenberger , Sabine Sadura , Andreas Meyer-Lindenberg , Wolfgang Wölwer","doi":"10.1016/j.schres.2025.02.015","DOIUrl":"10.1016/j.schres.2025.02.015","url":null,"abstract":"<div><h3>Introduction</h3><div>Persistent poor psychosocial functioning, which is associated with impairments in cognition, is one of the main barriers to recovery in schizophrenia. Although cognitive remediation therapy (CRT) has shown general efficacy in improving cognition and functioning, simultaneously focusing on social cognition and social behavioural processes may increase its efficacy.</div></div><div><h3>Methods</h3><div>In a multicenter, rater-blinded, randomized controlled trial, schizophrenia patients (N = 177) were assigned to six months of either Integrated Social Cognitive and Behavioral Skills Therapy (ISST) or, as an active control intervention, Neurocognitive Remediation Therapy (NCRT). The primary endpoint was all-cause discontinuation (ACD) over the 12-month study period. Secondary endpoints were cognition, psychosocial functioning and quality of life, and clinical symptoms.</div></div><div><h3>Results</h3><div>ACD was not significantly different between the ISST and NCRT groups (43.3 % vs 34.5 %, respectively). More improvement was seen in social cognition (Pictures of Facial Affect; d = 0.83) in the ISST group and in neurocognition (subscores of the Auditory Verbal Learning Test; d = 0.29–0.40) in the NCRT group. Level of functioning, quality of life, and clinical symptoms significantly improved in both groups, with no significant between-group differences.</div></div><div><h3>Discussion</h3><div>Both therapies differentially improved measures of the cognitive domains they were designed for. Moreover, they both improved social functioning with high effect sizes (d = 0.8–1.0), underlining the important role of CRT in recovery-oriented schizophrenia treatment. However, the absence of a third group without an active intervention limits the interpretability of the results.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"277 ","pages":"Pages 44-56"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01DOI: 10.1016/j.schres.2025.02.010
Sofie von Känel , Anastasia Pavlidou , Niluja Nadesalingam , Victoria Chapellier , Melanie G. Nuoffer , Alexandra Kyrou , Lydia Maderthaner , Florian Wüthrich , Stephanie Lefebvre , Sebastian Walther
Motor abnormalities are highly prevalent among patients with schizophrenia spectrum disorders. Very likely, motor control processes, such as dexterity and grip force (GF), are impaired in schizophrenia. We aimed to explore associations between various motor abnormalities and motor control processes and to investigate whether specific motor abnormalities predict the performance of fine motor movements and GF.
Our analyses included 198 patients with schizophrenia spectrum disorders. We applied well-established standardized motor rating scales to assess five different motor abnormalities: psychomotor slowing (PS), neurological soft signs (NSS), parkinsonism, catatonia, and dyskinesia. As a measure of manual dexterity, we used the coin rotation (CR) task, requiring patients to rotate a coin between their thumb, index, and middle finger. Maximal grip strength was measured with the GF task.
Correlation analyses revealed that both CR and GF performances were associated with different motor abnormalities, most strongly with NSS (CR: tau = −0.263, p < 0.001; GF: tau = −0.208, p < 0.001). Hierarchical regression showed that NSS predicted performance on the CR and GF task better compared to PS, parkinsonism, and catatonia alone (CR: ∆R2 = 0.09, F = 22.26, p < 0.001; GF: ∆R2 = 0.02, F = 6.61, p < 0.001). When looking within the NSS domains, CR performance was predicted better by motor coordination and sequencing of motor acts, whereas GF was predicted better by sensory integration.
Motor control processes are influenced by different motor abnormalities, especially NSS. Our results suggest that distinct aspects of NSS affect fine motor movements and GF. This knowledge is important for designing specific novel interventions aimed at improving specific motor control processes.
{"title":"Manual dexterity and grip force are distinctly linked to domains of neurological soft signs in schizophrenia spectrum disorders","authors":"Sofie von Känel , Anastasia Pavlidou , Niluja Nadesalingam , Victoria Chapellier , Melanie G. Nuoffer , Alexandra Kyrou , Lydia Maderthaner , Florian Wüthrich , Stephanie Lefebvre , Sebastian Walther","doi":"10.1016/j.schres.2025.02.010","DOIUrl":"10.1016/j.schres.2025.02.010","url":null,"abstract":"<div><div>Motor abnormalities are highly prevalent among patients with schizophrenia spectrum disorders. Very likely, motor control processes, such as dexterity and grip force (GF), are impaired in schizophrenia. We aimed to explore associations between various motor abnormalities and motor control processes and to investigate whether specific motor abnormalities predict the performance of fine motor movements and GF.</div><div>Our analyses included 198 patients with schizophrenia spectrum disorders. We applied well-established standardized motor rating scales to assess five different motor abnormalities: psychomotor slowing (PS), neurological soft signs (NSS), parkinsonism, catatonia, and dyskinesia. As a measure of manual dexterity, we used the coin rotation (CR) task, requiring patients to rotate a coin between their thumb, index, and middle finger. Maximal grip strength was measured with the GF task.</div><div>Correlation analyses revealed that both CR and GF performances were associated with different motor abnormalities, most strongly with NSS (CR: tau = −0.263, <em>p</em> < 0.001; GF: tau = −0.208, p < 0.001). Hierarchical regression showed that NSS predicted performance on the CR and GF task better compared to PS, parkinsonism, and catatonia alone (CR: ∆R<sup>2</sup> = 0.09, F = 22.26, <em>p</em> < 0.001; GF: ∆R<sup>2</sup> = 0.02, F = 6.61, p < 0.001). When looking within the NSS domains, CR performance was predicted better by motor coordination and sequencing of motor acts, whereas GF was predicted better by sensory integration.</div><div>Motor control processes are influenced by different motor abnormalities, especially NSS. Our results suggest that distinct aspects of NSS affect fine motor movements and GF. This knowledge is important for designing specific novel interventions aimed at improving specific motor control processes.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"277 ","pages":"Pages 65-73"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01DOI: 10.1016/j.schres.2025.01.029
Linda Hoeksema , Jojanneke Bruins , Marieke E. Timmerman , Stynke Castelein
Purpose
Women generally have a later age of onset, and may therefore have a more favourable course of psychotic illness than men regarding psychopathology. Little is known about a broader range of outcomes, including well-being and recovery, and about the influence of age of onset. This study examines longitudinal sex-related and age of onset-related differences in well-being and recovery of people with a psychotic disorder with long illness durations.
Methods
Routine outcome monitoring data (2012−2021) of n = 3843 patients were used. Well-being (quality of life and personal recovery) and recovery (clinical and societal recovery and psychosocial functioning) were assessed. Latent class growth analysis (LCGA) was performed to assess whether classes with different trajectories of well-being and recovery could be identified. Classes were related to sex and (early/late) age of onset of psychosis (EOP/LOP).
Results
LCGA identified five classes with varying combinations in levels of well-being and recovery, which were stable over time. Sex, age of onset and the combination of these two were significantly related to class membership. Women and individuals with LOP were more prevalent in better functioning classes than men and individuals with EOP.
Conclusion
This study showed sex differences in long-term recovery patterns of psychosis. Not only women but also individuals with LOP had a higher chance of better well-being and recovery, while men with EOP were at risk for worse outcomes. Taking these sex differences into account when deciding on policy and treatment protocols for individual patients might provide better mental health care to people with psychosis.
{"title":"Sex differences and age of onset in well-being and recovery in people with psychotic disorders. A PHAMOUS study","authors":"Linda Hoeksema , Jojanneke Bruins , Marieke E. Timmerman , Stynke Castelein","doi":"10.1016/j.schres.2025.01.029","DOIUrl":"10.1016/j.schres.2025.01.029","url":null,"abstract":"<div><h3>Purpose</h3><div>Women generally have a later age of onset, and may therefore have a more favourable course of psychotic illness than men regarding psychopathology. Little is known about a broader range of outcomes, including well-being and recovery, and about the influence of age of onset. This study examines longitudinal sex-related and age of onset-related differences in well-being and recovery of people with a psychotic disorder with long illness durations.</div></div><div><h3>Methods</h3><div>Routine outcome monitoring data (2012−2021) of n = 3843 patients were used. Well-being (quality of life and personal recovery) and recovery (clinical and societal recovery and psychosocial functioning) were assessed. Latent class growth analysis (LCGA) was performed to assess whether classes with different trajectories of well-being and recovery could be identified. Classes were related to sex and (early/late) age of onset of psychosis (EOP/LOP).</div></div><div><h3>Results</h3><div>LCGA identified five classes with varying combinations in levels of well-being and recovery, which were stable over time. Sex, age of onset and the combination of these two were significantly related to class membership. Women and individuals with LOP were more prevalent in better functioning classes than men and individuals with EOP.</div></div><div><h3>Conclusion</h3><div>This study showed sex differences in long-term recovery patterns of psychosis. Not only women but also individuals with LOP had a higher chance of better well-being and recovery, while men with EOP were at risk for worse outcomes. Taking these sex differences into account when deciding on policy and treatment protocols for individual patients might provide better mental health care to people with psychosis.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"277 ","pages":"Pages 86-92"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01DOI: 10.1016/j.schres.2025.02.004
Jill A. Marsteller , Richard W. Goldberg , Yasmine Boumaiz , Megan B.E. Jumper , Jessica Taylor , Arunadevi Saravana , Robert W. Buchanan , K.N. Roy Chengappa , Catherine G. Conroy , Faith Dickerson , Arielle Ered , Nev Jones , Christian G. Kohler , Julie Kreyenbuhl , Alicia Lucksted , Russell L. Margolis , Deborah Medoff , Peter Phalen , Deepak K. Sarpal , William R. Smith , Melanie E. Bennett
The Connection Learning Healthcare System (CLHS) represents a network of academic institutions, state behavioral health systems, and early psychosis specialty care programs in Pennsylvania and Maryland working together to provide the best evidence-based care for persons with first episode psychosis. Developing an integrated, two-state system required unification and harmonization of data collection, training, consultation, research, and dissemination activities. Here we describe the model that supported these efforts and our experience creating an active two-state learning healthcare system. We also review areas of ongoing attention and offer lessons learned.
{"title":"Building a two-state learning healthcare system for persons with first episode psychosis","authors":"Jill A. Marsteller , Richard W. Goldberg , Yasmine Boumaiz , Megan B.E. Jumper , Jessica Taylor , Arunadevi Saravana , Robert W. Buchanan , K.N. Roy Chengappa , Catherine G. Conroy , Faith Dickerson , Arielle Ered , Nev Jones , Christian G. Kohler , Julie Kreyenbuhl , Alicia Lucksted , Russell L. Margolis , Deborah Medoff , Peter Phalen , Deepak K. Sarpal , William R. Smith , Melanie E. Bennett","doi":"10.1016/j.schres.2025.02.004","DOIUrl":"10.1016/j.schres.2025.02.004","url":null,"abstract":"<div><div>The Connection Learning Healthcare System (CLHS) represents a network of academic institutions, state behavioral health systems, and early psychosis specialty care programs in Pennsylvania and Maryland working together to provide the best evidence-based care for persons with first episode psychosis. Developing an integrated, two-state system required unification and harmonization of data collection, training, consultation, research, and dissemination activities. Here we describe the model that supported these efforts and our experience creating an active two-state learning healthcare system. We also review areas of ongoing attention and offer lessons learned.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"277 ","pages":"Pages 74-85"},"PeriodicalIF":3.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-26DOI: 10.1016/j.schres.2025.02.014
Lena Palaniyappan , Oliver Delgaram-Nejad
{"title":"Commentary: Examining language and selfhood in hallucinations","authors":"Lena Palaniyappan , Oliver Delgaram-Nejad","doi":"10.1016/j.schres.2025.02.014","DOIUrl":"10.1016/j.schres.2025.02.014","url":null,"abstract":"","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"277 ","pages":"Pages 42-43"},"PeriodicalIF":3.6,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-26DOI: 10.1016/j.schres.2025.02.005
André Barciela Veras , Karyson Macruz Ribeiro , Clayton Peixoto , Natia Horato , Jeffrey Paul Kahn , Antonio Egidio Nardi
Background
The classical description of panic psychosis is characterized by existence of paroxysmal panic anxiety concurrent with auditory hallucinations or paranoid delusions. Although there is a high prevalence of panic comorbidity in schizophrenia, there remains much uncertainty among clinicians.
Aims
We aim to describe the psychopathological manifestations and pathogenetic factors of subjects with schizophrenia spectrum disorders comorbid with panic disorder. Adequate diagnosis and treatment of these conditions can produce significant amelioration of co-morbidities and psychotic symptoms.
Methods
Studies included in the review were selected through electronic search in these databases: Medical Literature databases and Retrieval System Online (Medline), Latin American and Caribbean Health Sciences (LILACS) and the Cochrane Library. Included were clinical studies in which schizophrenia spectrum disorder subjects had their diagnoses confirmed according to criteria from systematized manuals, and who also were evaluated with standardized scales for psychiatric symptomatology (psychosis, diagnosis of panic disorder or panic attacks, anxiety and general symptoms).
Results
We found a total of 449 results from electronic searches. Only twenty-five studies fully met the inclusion criteria for this review. Two main methodological approaches were identified: 1. Clinical studies which specifically focused on patients with Schizophrenia Spectrum Disorders (SSD) with comorbid Panic Disorder (PD) (N = 11); 2. Clinical studies which examined broader groups of SSD patients (N = 13) for Panic symptoms.
Conclusion
Comparative studies show that SSD patients with PD comorbidity usually have more severe psychotic symptomatology, more depressive symptoms, more suicide ideation, earlier onset, and worse outcome. Correlation analysis confirmed the association of panic with more depressive symptoms, early onset, and worse functioning. In addition, other risk factors such as early trauma, hypovitaminosis D and a cross familiar risk are considered.
{"title":"Schizophrenia spectrum disorders with comorbid panic: A systematic review","authors":"André Barciela Veras , Karyson Macruz Ribeiro , Clayton Peixoto , Natia Horato , Jeffrey Paul Kahn , Antonio Egidio Nardi","doi":"10.1016/j.schres.2025.02.005","DOIUrl":"10.1016/j.schres.2025.02.005","url":null,"abstract":"<div><h3>Background</h3><div>The classical description of panic psychosis is characterized by existence of paroxysmal panic anxiety concurrent with auditory hallucinations or paranoid delusions. Although there is a high prevalence of panic comorbidity in schizophrenia, there remains much uncertainty among clinicians.</div></div><div><h3>Aims</h3><div>We aim to describe the psychopathological manifestations and pathogenetic factors of subjects with schizophrenia spectrum disorders comorbid with panic disorder. Adequate diagnosis and treatment of these conditions can produce significant amelioration of co-morbidities and psychotic symptoms.</div></div><div><h3>Methods</h3><div>Studies included in the review were selected through electronic search in these databases: Medical Literature databases and Retrieval System Online (Medline), Latin American and Caribbean Health Sciences (LILACS) and the Cochrane Library. Included were clinical studies in which schizophrenia spectrum disorder subjects had their diagnoses confirmed according to criteria from systematized manuals, and who also were evaluated with standardized scales for psychiatric symptomatology (psychosis, diagnosis of panic disorder or panic attacks, anxiety and general symptoms).</div></div><div><h3>Results</h3><div>We found a total of 449 results from electronic searches. Only twenty-five studies fully met the inclusion criteria for this review. Two main methodological approaches were identified: 1. Clinical studies which specifically focused on patients with Schizophrenia Spectrum Disorders (SSD) with comorbid Panic Disorder (PD) (<em>N</em> = 11); 2. Clinical studies which examined broader groups of SSD patients (<em>N</em> = 13) for Panic symptoms.</div></div><div><h3>Conclusion</h3><div>Comparative studies show that SSD patients with PD comorbidity usually have more severe psychotic symptomatology, more depressive symptoms, more suicide ideation, earlier onset, and worse outcome. Correlation analysis confirmed the association of panic with more depressive symptoms, early onset, and worse functioning. In addition, other risk factors such as early trauma, hypovitaminosis D and a cross familiar risk are considered.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"277 ","pages":"Pages 33-41"},"PeriodicalIF":3.6,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-20DOI: 10.1016/j.schres.2025.02.001
Amal Abdel-Baki , Manuela Ferrari , Annie Leblanc , Camille Arbaud , Daniel Rabouin , Marc-André Roy , Srividya N. Iyer
Introduction
Despite growing interest in learning health systems, their application and evaluation in mental health have been scarce. This study aimed to evaluate the feasibility, acceptability and early impacts of SARPEP, a rapid learning healthcare system (RLHS) for early intervention services for psychosis in Quebec, Canada.
Methods
SARPEP comprised technology-supported monitoring of program and patient outcomes, feedback and capacity-building. It involved 11 services (128 professionals, 1700+ patients). We descriptively analyzed quantitative data on the RE-AIM framework (Reach, Effectiveness, Adoption, Implementation, Maintenance) collected in the first two years.
Results
Reach: Patient and family partners, all programs (clinicians, managers), government representatives and the provincial early psychosis association agreed to co-design and implement all SARPEP components. Effectiveness: Data informed program- and provincial-level decision-making. Some quality indicators (e.g., timely access) improved over time. 80 % of youth were satisfied with services. Adoption: All programs collected data on satisfaction and quality, with data collection improving over time. Eight programs and all stakeholder groups participated in most community-of-practice sessions. Implementation: The time required for data collection and providing feedback decreased over time. SARPEP offered rapid, flexible support; tools; and a community of practice that facilitated collecting data, and monitoring and improving practices. Maintenance: All programs remained in SARPEP post study.
Conclusion
Involving all stakeholders, RLHSs can be deployed, adopted, and maintained in mental healthcare and increase the measurement of practices and quality improvement efforts. Strategies are needed to increase the completion of patient-reported measures and to rigorously evaluate the RLHS' effectiveness in improving service quality and outcomes.
{"title":"SARPEP, a rapid-learning healthcare system of early intervention services for psychosis in Quebec, Canada: Feasibility, acceptability and early impacts","authors":"Amal Abdel-Baki , Manuela Ferrari , Annie Leblanc , Camille Arbaud , Daniel Rabouin , Marc-André Roy , Srividya N. Iyer","doi":"10.1016/j.schres.2025.02.001","DOIUrl":"10.1016/j.schres.2025.02.001","url":null,"abstract":"<div><h3>Introduction</h3><div>Despite growing interest in learning health systems, their application and evaluation in mental health have been scarce. This study aimed to evaluate the feasibility, acceptability and early impacts of SARPEP, a rapid learning healthcare system (RLHS) for early intervention services for psychosis in Quebec, Canada.</div></div><div><h3>Methods</h3><div>SARPEP comprised technology-supported monitoring of program and patient outcomes, feedback and capacity-building. It involved 11 services (128 professionals, 1700+ patients). We descriptively analyzed quantitative data on the RE-AIM framework (Reach, Effectiveness, Adoption, Implementation, Maintenance) collected in the first two years.</div></div><div><h3>Results</h3><div><em>Reach</em>: Patient and family partners, all programs (clinicians, managers), government representatives and the provincial early psychosis association agreed to co-design and implement all SARPEP components. <em>Effectiveness</em>: Data informed program- and provincial-level decision-making. Some quality indicators (e.g., timely access) improved over time. 80 % of youth were satisfied with services. <em>Adoption</em>: All programs collected data on satisfaction and quality, with data collection improving over time. Eight programs and all stakeholder groups participated in most community-of-practice sessions. <em>Implementation</em>: The time required for data collection and providing feedback decreased over time. SARPEP offered rapid, flexible support; tools; and a community of practice that facilitated collecting data, and monitoring and improving practices. <em>Maintenance</em>: All programs remained in SARPEP post study.</div></div><div><h3>Conclusion</h3><div>Involving all stakeholders, RLHSs can be deployed, adopted, and maintained in mental healthcare and increase the measurement of practices and quality improvement efforts. Strategies are needed to increase the completion of patient-reported measures and to rigorously evaluate the RLHS' effectiveness in improving service quality and outcomes.</div></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":"277 ","pages":"Pages 20-30"},"PeriodicalIF":3.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143453888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-18DOI: 10.1016/j.schres.2025.01.011
Lynn E. DeLisi
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