Daiana da Silva Ferreira, Ana Rita Vianna Potrich, Amanda de Farias Gabriel, Lauren Neumann Villarinho, Julia Souza Führ, Marco Antonio Trevizani Martins, Manoela Domingues Martins
{"title":"Medication-related osteonecrosis of the jaw: a case report","authors":"Daiana da Silva Ferreira, Ana Rita Vianna Potrich, Amanda de Farias Gabriel, Lauren Neumann Villarinho, Julia Souza Führ, Marco Antonio Trevizani Martins, Manoela Domingues Martins","doi":"10.1016/j.oooo.2025.01.079","DOIUrl":null,"url":null,"abstract":"<div><div>Medication-related osteonecrosis of the jaw (MROJ) represents a challenge for patients taking antiangiogenic and antiresorptive medications. Here we present a case involving a 55-year-old man with lupus and type 2 diabetes, treated with alendronate sodium. After multiple extractions, there was bone exposure accompanied by an infectious condition in the operated regions. In addition, he had ulcers and erythema on the oral mucosa. Surgical interventions of debridement of necrotic bone tissue, antimicrobial photodynamic therapy (aPDT) and photobiomodulation (FBM) were used as treatment, we addressed his MROJ. After carrying out the proposed treatment, the lesions are in remission but are still being monitored. Laser technology, increasingly favored for surgeries and therapies such as aPDT and FBM, was fundamental. Although this multidimensional approach shows promise, thorough studies are imperative to assess relapse risks and long-term outcomes. This study emphasizes the continued need to refine MROJ treatments, given their complexity and profound implications.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 5","pages":"Page e15"},"PeriodicalIF":2.0000,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2212440325000823","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
Medication-related osteonecrosis of the jaw (MROJ) represents a challenge for patients taking antiangiogenic and antiresorptive medications. Here we present a case involving a 55-year-old man with lupus and type 2 diabetes, treated with alendronate sodium. After multiple extractions, there was bone exposure accompanied by an infectious condition in the operated regions. In addition, he had ulcers and erythema on the oral mucosa. Surgical interventions of debridement of necrotic bone tissue, antimicrobial photodynamic therapy (aPDT) and photobiomodulation (FBM) were used as treatment, we addressed his MROJ. After carrying out the proposed treatment, the lesions are in remission but are still being monitored. Laser technology, increasingly favored for surgeries and therapies such as aPDT and FBM, was fundamental. Although this multidimensional approach shows promise, thorough studies are imperative to assess relapse risks and long-term outcomes. This study emphasizes the continued need to refine MROJ treatments, given their complexity and profound implications.
期刊介绍:
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology is required reading for anyone in the fields of oral surgery, oral medicine, oral pathology, oral radiology or advanced general practice dentistry. It is the only major dental journal that provides a practical and complete overview of the medical and surgical techniques of dental practice in four areas. Topics covered include such current issues as dental implants, treatment of HIV-infected patients, and evaluation and treatment of TMJ disorders. The official publication for nine societies, the Journal is recommended for initial purchase in the Brandon Hill study, Selected List of Books and Journals for the Small Medical Library.