Medication-related osteonecrosis of the jaw: a case report

Abstract

Medication-related osteonecrosis of the jaw (MROJ) represents a challenge for patients taking antiangiogenic and antiresorptive medications. Here we present a case involving a 55-year-old man with lupus and type 2 diabetes, treated with alendronate sodium. After multiple extractions, there was bone exposure accompanied by an infectious condition in the operated regions. In addition, he had ulcers and erythema on the oral mucosa. Surgical interventions of debridement of necrotic bone tissue, antimicrobial photodynamic therapy (aPDT) and photobiomodulation (FBM) were used as treatment, we addressed his MROJ. After carrying out the proposed treatment, the lesions are in remission but are still being monitored. Laser technology, increasingly favored for surgeries and therapies such as aPDT and FBM, was fundamental. Although this multidimensional approach shows promise, thorough studies are imperative to assess relapse risks and long-term outcomes. This study emphasizes the continued need to refine MROJ treatments, given their complexity and profound implications.