Medication-related osteonecrosis of the jaw: a case report

IF 2 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-03-14 DOI:10.1016/j.oooo.2025.01.079
Daiana da Silva Ferreira, Ana Rita Vianna Potrich, Amanda de Farias Gabriel, Lauren Neumann Villarinho, Julia Souza Führ, Marco Antonio Trevizani Martins, Manoela Domingues Martins
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Abstract

Medication-related osteonecrosis of the jaw (MROJ) represents a challenge for patients taking antiangiogenic and antiresorptive medications. Here we present a case involving a 55-year-old man with lupus and type 2 diabetes, treated with alendronate sodium. After multiple extractions, there was bone exposure accompanied by an infectious condition in the operated regions. In addition, he had ulcers and erythema on the oral mucosa. Surgical interventions of debridement of necrotic bone tissue, antimicrobial photodynamic therapy (aPDT) and photobiomodulation (FBM) were used as treatment, we addressed his MROJ. After carrying out the proposed treatment, the lesions are in remission but are still being monitored. Laser technology, increasingly favored for surgeries and therapies such as aPDT and FBM, was fundamental. Although this multidimensional approach shows promise, thorough studies are imperative to assess relapse risks and long-term outcomes. This study emphasizes the continued need to refine MROJ treatments, given their complexity and profound implications.
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药物相关性颌骨坏死(MROJ)是服用抗血管生成和抗骨吸收药物的患者面临的一项挑战。在此,我们介绍了一个病例,患者是一名55岁的男性,患有狼疮和2型糖尿病,正在接受阿仑膦酸钠治疗。在多次拔牙后,手术区域出现骨暴露并伴有感染。此外,他的口腔粘膜还出现了溃疡和红斑。我们采用了清创坏死骨组织、抗菌光动力疗法(aPDT)和光生物调制(FBM)等手术干预治疗方法,解决了他的 MROJ 问题。在进行了建议的治疗后,病变得到了缓解,但仍在观察之中。激光技术在 aPDT 和 FBM 等手术和治疗中越来越受青睐,它是治疗的基础。尽管这种多维治疗方法前景看好,但仍有必要进行深入研究,以评估复发风险和长期疗效。鉴于 MROJ 的复杂性和深远影响,本研究强调了继续完善 MROJ 治疗方法的必要性。
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来源期刊
Oral Surgery Oral Medicine Oral Pathology Oral Radiology
Oral Surgery Oral Medicine Oral Pathology Oral Radiology DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
3.80
自引率
6.90%
发文量
1217
审稿时长
2-4 weeks
期刊介绍: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology is required reading for anyone in the fields of oral surgery, oral medicine, oral pathology, oral radiology or advanced general practice dentistry. It is the only major dental journal that provides a practical and complete overview of the medical and surgical techniques of dental practice in four areas. Topics covered include such current issues as dental implants, treatment of HIV-infected patients, and evaluation and treatment of TMJ disorders. The official publication for nine societies, the Journal is recommended for initial purchase in the Brandon Hill study, Selected List of Books and Journals for the Small Medical Library.
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