Advances of novel hydrogels in the healing process of alveolar sockets

IF 6 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS Materials Science & Engineering C-Materials for Biological Applications Pub Date : 2025-03-09 DOI:10.1016/j.bioadv.2025.214280

Wenqing Yu , Liwei Hu , Yige Wei , Chengyu Xue , Yunfei Liu , Huixu Xie

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Abstract

Tooth extraction is a common oral surgical procedure that often leads to delayed alveolar socket healing due to the complexity of the oral microenvironment, which can hinder the patient's aesthetic and functional recovery. Effective alveolar socket healing requires a multidisciplinary approach. Recent advancements in materials science and bioengineering have facilitated the development of innovative strategies, with hydrogels emerging as ideal restorative materials for alveolar socket repair due to their superior properties. This review provides an overview of recent advances in hydrogels for alveolar socket healing, focusing on their classification, physical properties (e.g., mechanical strength, swelling behavior, degradation rate, and injectability), biological functions, and applications in relevant animal models. Specifically, the bone-regenerative and antimicrobial properties of hydrogels are highlighted. Furthermore, this review identifies future directions and addresses challenges associated with the clinical application of hydrogels in extraction socket healing.

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新型水凝胶在牙槽窝愈合中的研究进展

拔牙是一种常见的口腔外科手术，由于口腔微环境的复杂性，拔牙往往会导致牙槽窝愈合延迟，从而阻碍患者的审美和功能恢复。有效的牙槽窝愈合需要多学科的联合治疗。最近材料科学和生物工程的进步促进了创新策略的发展，水凝胶由于其优越的性能而成为牙槽窝修复的理想修复材料。本文综述了用于牙槽窝愈合的水凝胶的最新进展，重点介绍了水凝胶的分类、物理特性（如机械强度、肿胀行为、降解率和可注射性）、生物学功能以及在相关动物模型中的应用。具体地说，水凝胶的骨再生和抗菌特性是突出的。此外，本综述确定了水凝胶在拔牙窝愈合中的临床应用的未来方向和挑战。

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来源期刊

Materials Science & Engineering C-Materials for Biological Applications 工程技术-材料科学：生物材料

CiteScore

17.80

自引率

0.00%

发文量

501

审稿时长

27 days

期刊介绍： Biomaterials Advances, previously known as Materials Science and Engineering: C-Materials for Biological Applications (P-ISSN: 0928-4931, E-ISSN: 1873-0191). Includes topics at the interface of the biomedical sciences and materials engineering. These topics include: • Bioinspired and biomimetic materials for medical applications • Materials of biological origin for medical applications • Materials for "active" medical applications • Self-assembling and self-healing materials for medical applications • "Smart" (i.e., stimulus-response) materials for medical applications • Ceramic, metallic, polymeric, and composite materials for medical applications • Materials for in vivo sensing • Materials for in vivo imaging • Materials for delivery of pharmacologic agents and vaccines • Novel approaches for characterizing and modeling materials for medical applications Manuscripts on biological topics without a materials science component, or manuscripts on materials science without biological applications, will not be considered for publication in Materials Science and Engineering C. New submissions are first assessed for language, scope and originality (plagiarism check) and can be desk rejected before review if they need English language improvements, are out of scope or present excessive duplication with published sources. Biomaterials Advances sits within Elsevier''s biomaterials science portfolio alongside Biomaterials, Materials Today Bio and Biomaterials and Biosystems. As part of the broader Materials Today family, Biomaterials Advances offers authors rigorous peer review, rapid decisions, and high visibility. We look forward to receiving your submissions!