Abdalrahman Alblwi;Saleh Makkawy;Kenneth E. Barner
{"title":"D-DDPM: Deep Denoising Diffusion Probabilistic Models for Lesion Segmentation and Data Generation in Ultrasound Imaging","authors":"Abdalrahman Alblwi;Saleh Makkawy;Kenneth E. Barner","doi":"10.1109/ACCESS.2025.3548128","DOIUrl":null,"url":null,"abstract":"The Denoising Diffusion Probabilistic Model (DDPM) has gained significant attention for its powerful image generation and segmentation capabilities, particularly in biomedical applications where accuracy is critical. In breast cancer detection, ultrasound imaging is widely used due to its safety, affordability, and non-ionizing nature. However, the inherent challenges of ultrasound data, such as noise and artifacts, make accurate tumor segmentation difficult, often leading to misdiagnosis. We propose a novel Deep Denoising Probabilistic Diffusion Model (D-DDPM) designed to enhance tumor segmentation in breast ultrasound images to address these limitations. Our model incorporates a nested U-Net architecture with Residual U-blocks (RSU), significantly improving feature learning and segmentation precision. In addition to performing segmentation, D-DDPM generates synthetic data, augmenting existing real datasets to improve data size with a diverse range of high-quality samples. We validated D-DDPM on several breast ultrasound datasets, comparing its performance to state-of-the-art methods. The proposed D-DDPM achieves a Dice score improvement of 2.26%, 4.24%, and 5% over the runner-up model, demonstrating superior performance on all BUS datasets. Both qualitative and quantitative results demonstrate the ability of D-DDPM to deliver more accurate and reliable segmentation results, offering promising potential to improve clinical decision-making in cancer diagnosis.","PeriodicalId":13079,"journal":{"name":"IEEE Access","volume":"13 ","pages":"41194-41209"},"PeriodicalIF":3.4000,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10910103","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"IEEE Access","FirstCategoryId":"94","ListUrlMain":"https://ieeexplore.ieee.org/document/10910103/","RegionNum":3,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"COMPUTER SCIENCE, INFORMATION SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
The Denoising Diffusion Probabilistic Model (DDPM) has gained significant attention for its powerful image generation and segmentation capabilities, particularly in biomedical applications where accuracy is critical. In breast cancer detection, ultrasound imaging is widely used due to its safety, affordability, and non-ionizing nature. However, the inherent challenges of ultrasound data, such as noise and artifacts, make accurate tumor segmentation difficult, often leading to misdiagnosis. We propose a novel Deep Denoising Probabilistic Diffusion Model (D-DDPM) designed to enhance tumor segmentation in breast ultrasound images to address these limitations. Our model incorporates a nested U-Net architecture with Residual U-blocks (RSU), significantly improving feature learning and segmentation precision. In addition to performing segmentation, D-DDPM generates synthetic data, augmenting existing real datasets to improve data size with a diverse range of high-quality samples. We validated D-DDPM on several breast ultrasound datasets, comparing its performance to state-of-the-art methods. The proposed D-DDPM achieves a Dice score improvement of 2.26%, 4.24%, and 5% over the runner-up model, demonstrating superior performance on all BUS datasets. Both qualitative and quantitative results demonstrate the ability of D-DDPM to deliver more accurate and reliable segmentation results, offering promising potential to improve clinical decision-making in cancer diagnosis.
IEEE AccessCOMPUTER SCIENCE, INFORMATION SYSTEMSENGIN-ENGINEERING, ELECTRICAL & ELECTRONIC
CiteScore
9.80
自引率
7.70%
发文量
6673
审稿时长
6 weeks
期刊介绍:
IEEE Access® is a multidisciplinary, open access (OA), applications-oriented, all-electronic archival journal that continuously presents the results of original research or development across all of IEEE''s fields of interest.
IEEE Access will publish articles that are of high interest to readers, original, technically correct, and clearly presented. Supported by author publication charges (APC), its hallmarks are a rapid peer review and publication process with open access to all readers. Unlike IEEE''s traditional Transactions or Journals, reviews are "binary", in that reviewers will either Accept or Reject an article in the form it is submitted in order to achieve rapid turnaround. Especially encouraged are submissions on:
Multidisciplinary topics, or applications-oriented articles and negative results that do not fit within the scope of IEEE''s traditional journals.
Practical articles discussing new experiments or measurement techniques, interesting solutions to engineering.
Development of new or improved fabrication or manufacturing techniques.
Reviews or survey articles of new or evolving fields oriented to assist others in understanding the new area.