Prevalence, trends, and geographic distribution of human papillomavirus infection in Chinese women: a summative analysis of 2,728,321 cases.

IF 8.3 1区医学 Q1 MEDICINE, GENERAL & INTERNAL BMC Medicine Pub Date : 2025-03-13 DOI:10.1186/s12916-025-03975-6

Sirui Han, Mengyue Lin, Mengyu Liu, Shiwan Wu, Pi Guo, Jiubiao Guo, Longxu Xie, Song Qiu, Aijuan Xu, Yingmu Cai, Yequn Chen

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Abstract

Background: Cervical cancer (CC), primarily caused by human papillomavirus (HPV) infection, remains a significant global health concern. We aimed to comprehensively investigate the epidemiological status of HPV in China.

Methods: Data from 2,728,321 women undergoing routine cervical examinations at 2127 medical institutions nationwide from January 2017 to June 2023 were analyzed. HPV genotype testing was conducted using HPV DNA typing kits.

Results: The overall HPV prevalence was 17.70%, with 13.12% classified as high-risk HPV (HR-HPV) and 4.58% as low-risk HPV (LR-HPV). Notably, HPV52 emerged as the most common carcinogenic type, followed by HPV58 and HPV16. Age-specific prevalence revealed a bimodal distribution, with peaks observed in women under 21 and over 61 years of age. Geographically, the south (19.48%) exhibited the highest infection rate, while the northwest (12.36%) had the lowest. Furthermore, HPV infection rates were higher during winter and spring. Although HPV infection rates have remained stable overall over the past 7 years, the infection rate in 2023 (14.76%) has declined relative to 2017 (16.17%) (P < 0.05).

Conclusions: This study provides comprehensive insight into HPV epidemiology in China and guidance for future vaccine development and cervical cancer prevention strategies.

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中国女性人乳头瘤病毒感染的流行、趋势和地理分布：对2728321例病例的总结分析

背景：宫颈癌（CC），主要是由人乳头瘤病毒（HPV）感染引起的，仍然是一个重要的全球健康问题。我们的目的是全面调查HPV在中国的流行病学状况。方法：分析2017年1月至2023年6月在全国2127家医疗机构进行宫颈常规检查的2,728,321名妇女的数据。采用HPV DNA分型试剂盒进行HPV基因型检测。结果：总体HPV患病率为17.70%，其中高危HPV （HR-HPV）为13.12%，低危HPV （LR-HPV）为4.58%。值得注意的是，HPV52是最常见的致癌类型，其次是HPV58和HPV16。不同年龄的患病率呈双峰分布，在21岁以下和61岁以上的妇女中观察到高峰。从地域上看，南部感染率最高（19.48%），西北部最低（12.36%）。此外，HPV感染率在冬季和春季较高。虽然HPV感染率在过去7年总体保持稳定，但2023年的感染率（14.76%）相对于2017年（16.17%）有所下降(P)。结论：本研究为全面了解中国HPV流行病学，为未来疫苗开发和宫颈癌预防策略提供指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Medicine 医学-医学：内科

CiteScore

13.10

自引率

1.10%

发文量

435

审稿时长

4-8 weeks

期刊介绍： BMC Medicine is an open access, transparent peer-reviewed general medical journal. It is the flagship journal of the BMC series and publishes outstanding and influential research in various areas including clinical practice, translational medicine, medical and health advances, public health, global health, policy, and general topics of interest to the biomedical and sociomedical professional communities. In addition to research articles, the journal also publishes stimulating debates, reviews, unique forum articles, and concise tutorials. All articles published in BMC Medicine are included in various databases such as Biological Abstracts, BIOSIS, CAS, Citebase, Current contents, DOAJ, Embase, MEDLINE, PubMed, Science Citation Index Expanded, OAIster, SCImago, Scopus, SOCOLAR, and Zetoc.