Maternal-Fetal Listeriosis in China: Clinical and Genomic Characteristics From an ST8 Listeria monocytogenes Case.

IF 2.9 3区 医学 Q2 INFECTIOUS DISEASES Infection and Drug Resistance Pub Date : 2025-03-08 eCollection Date: 2025-01-01 DOI:10.2147/IDR.S508470
Gang Hu, Wei Yan, Fenfen Dong, Gang Li, Xiaoxing Zhang, Qiongshan Li, Peng Zhang, Lei Ji
{"title":"Maternal-Fetal Listeriosis in China: Clinical and Genomic Characteristics From an ST8 <i>Listeria monocytogenes</i> Case.","authors":"Gang Hu, Wei Yan, Fenfen Dong, Gang Li, Xiaoxing Zhang, Qiongshan Li, Peng Zhang, Lei Ji","doi":"10.2147/IDR.S508470","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Listeriosis, a severe foodborne infection caused by <i>Listeria monocytogenes</i>, poses significant risks during pregnancy, including maternal-neonatal transmission. This study describes the clinical and genomic characteristics of an sequence type 8 (ST8) <i>L. monocytogenes</i> strain involved in maternal-neonatal transmission during pregnancy.</p><p><strong>Methods: </strong>Clinical presentation, diagnostic process, and treatment outcomes of the case were documented in detail. Whole-genome sequencing (WGS) and subsequent genomic analyses were performed on <i>L. monocytogenes</i> isolates obtained from the maternal and neonatal blood cultures.</p><p><strong>Results: </strong>A 33-week pregnant woman presented with decreased fetal movements and underwent an emergency cesarean delivery. Postpartum, she developed a high fever, and blood cultures from both the mother and the neonate the day after caesarean delivery confirmed <i>L. monocytogenes</i> infection. WGS revealed that the isolates belonged to serotype 1/2a, ST8, clonal complex (CC) 8, and lineage II. Both isolates exhibited susceptibility to first-line antibiotics, including penicillin and ampicillin, and contained virulence and stress adaptation genes such as <i>LIPI-1</i> and SSI-1. Phylogenetic analysis based on cg-SNP linked the clinical isolates to foodborne ST8 strains from Huzhou and Shanghai, suggesting potential contamination routes.</p><p><strong>Conclusion: </strong>This case highlights the importance of timely diagnosis and effective antibiotic management in preventing adverse pregnancy outcomes. It also underscores the need for enhanced food safety surveillance and genomic monitoring of <i>L. monocytogenes</i> to better understand the transmission dynamics and to avoid the extension of a foodborne infection.</p>","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"18 ","pages":"1313-1324"},"PeriodicalIF":2.9000,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905801/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infection and Drug Resistance","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/IDR.S508470","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Listeriosis, a severe foodborne infection caused by Listeria monocytogenes, poses significant risks during pregnancy, including maternal-neonatal transmission. This study describes the clinical and genomic characteristics of an sequence type 8 (ST8) L. monocytogenes strain involved in maternal-neonatal transmission during pregnancy.

Methods: Clinical presentation, diagnostic process, and treatment outcomes of the case were documented in detail. Whole-genome sequencing (WGS) and subsequent genomic analyses were performed on L. monocytogenes isolates obtained from the maternal and neonatal blood cultures.

Results: A 33-week pregnant woman presented with decreased fetal movements and underwent an emergency cesarean delivery. Postpartum, she developed a high fever, and blood cultures from both the mother and the neonate the day after caesarean delivery confirmed L. monocytogenes infection. WGS revealed that the isolates belonged to serotype 1/2a, ST8, clonal complex (CC) 8, and lineage II. Both isolates exhibited susceptibility to first-line antibiotics, including penicillin and ampicillin, and contained virulence and stress adaptation genes such as LIPI-1 and SSI-1. Phylogenetic analysis based on cg-SNP linked the clinical isolates to foodborne ST8 strains from Huzhou and Shanghai, suggesting potential contamination routes.

Conclusion: This case highlights the importance of timely diagnosis and effective antibiotic management in preventing adverse pregnancy outcomes. It also underscores the need for enhanced food safety surveillance and genomic monitoring of L. monocytogenes to better understand the transmission dynamics and to avoid the extension of a foodborne infection.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
求助全文
约1分钟内获得全文 去求助
来源期刊
Infection and Drug Resistance
Infection and Drug Resistance Medicine-Pharmacology (medical)
CiteScore
5.60
自引率
7.70%
发文量
826
审稿时长
16 weeks
期刊介绍: About Journal Editors Peer Reviewers Articles Article Publishing Charges Aims and Scope Call For Papers ISSN: 1178-6973 Editor-in-Chief: Professor Suresh Antony An international, peer-reviewed, open access journal that focuses on the optimal treatment of infection (bacterial, fungal and viral) and the development and institution of preventative strategies to minimize the development and spread of resistance.
期刊最新文献
Maternal-Fetal Listeriosis in China: Clinical and Genomic Characteristics From an ST8 Listeria monocytogenes Case. Clinical Characteristics, Virulence Profile, and Molecular Epidemiology of Klebsiella pneumoniae Infections in Kidney Transplant Recipients. Are Glucocorticoids Truly Effective in Improving the Clinical Prognosis of HSV-1 Encephalitis? Pseudomembranous Aspergillus tracheobronchitis: A Rare Manifestation of Invasive Aspergillosis in a Immunocompetent Patient. AIDS-Associated Talaromyces marneffei Infection with Thoracic Spinal Cord Involvement Leading to Paraplegia: A Case Report and Literature Review.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1