Maternal-Fetal Listeriosis in China: Clinical and Genomic Characteristics From an ST8 Listeria monocytogenes Case.

IF 2.9 3区 医学 Q2 INFECTIOUS DISEASES Infection and Drug Resistance Pub Date : 2025-03-08 eCollection Date: 2025-01-01 DOI:10.2147/IDR.S508470
Gang Hu, Wei Yan, Fenfen Dong, Gang Li, Xiaoxing Zhang, Qiongshan Li, Peng Zhang, Lei Ji
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Abstract

Background: Listeriosis, a severe foodborne infection caused by Listeria monocytogenes, poses significant risks during pregnancy, including maternal-neonatal transmission. This study describes the clinical and genomic characteristics of an sequence type 8 (ST8) L. monocytogenes strain involved in maternal-neonatal transmission during pregnancy.

Methods: Clinical presentation, diagnostic process, and treatment outcomes of the case were documented in detail. Whole-genome sequencing (WGS) and subsequent genomic analyses were performed on L. monocytogenes isolates obtained from the maternal and neonatal blood cultures.

Results: A 33-week pregnant woman presented with decreased fetal movements and underwent an emergency cesarean delivery. Postpartum, she developed a high fever, and blood cultures from both the mother and the neonate the day after caesarean delivery confirmed L. monocytogenes infection. WGS revealed that the isolates belonged to serotype 1/2a, ST8, clonal complex (CC) 8, and lineage II. Both isolates exhibited susceptibility to first-line antibiotics, including penicillin and ampicillin, and contained virulence and stress adaptation genes such as LIPI-1 and SSI-1. Phylogenetic analysis based on cg-SNP linked the clinical isolates to foodborne ST8 strains from Huzhou and Shanghai, suggesting potential contamination routes.

Conclusion: This case highlights the importance of timely diagnosis and effective antibiotic management in preventing adverse pregnancy outcomes. It also underscores the need for enhanced food safety surveillance and genomic monitoring of L. monocytogenes to better understand the transmission dynamics and to avoid the extension of a foodborne infection.

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背景:李斯特菌病是由单核细胞增生李斯特菌引起的一种严重食源性感染,在妊娠期间具有很大的风险,包括母婴传播。本研究描述了一株涉及孕期母婴传播的序列8型(ST8)单核细胞增生李斯特菌的临床和基因组特征:方法:详细记录了该病例的临床表现、诊断过程和治疗结果。对从母体和新生儿血液培养中获得的单核细胞增生症分离株进行了全基因组测序(WGS)和后续的基因组分析:一名怀孕 33 周的孕妇因胎动减少而进行了紧急剖宫产。剖腹产后第二天,产妇和新生儿的血液培养均证实感染了单核细胞增多症。WGS显示,分离株属于血清型1/2a、ST8、克隆复合体(CC)8和血统II。两株分离物均对青霉素和氨苄西林等一线抗生素具有敏感性,并含有毒力基因和应激适应基因,如 LIPI-1 和 SSI-1。基于cg-SNP的系统发育分析将临床分离株与湖州和上海的食源性ST8菌株联系在一起,提示了潜在的污染途径:本病例强调了及时诊断和有效抗生素治疗对预防不良妊娠结局的重要性。结论:本病例强调了及时诊断和有效的抗生素管理对预防不良妊娠结局的重要性,同时也突出了加强食品安全监测和单核细胞增多症基因组监测的必要性,以更好地了解传播动态,避免食源性感染的扩大。
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来源期刊
Infection and Drug Resistance
Infection and Drug Resistance Medicine-Pharmacology (medical)
CiteScore
5.60
自引率
7.70%
发文量
826
审稿时长
16 weeks
期刊介绍: About Journal Editors Peer Reviewers Articles Article Publishing Charges Aims and Scope Call For Papers ISSN: 1178-6973 Editor-in-Chief: Professor Suresh Antony An international, peer-reviewed, open access journal that focuses on the optimal treatment of infection (bacterial, fungal and viral) and the development and institution of preventative strategies to minimize the development and spread of resistance.
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