Exploring the Protective Role of Recombinant Type III Interferons in Respiratory Infections: Insights from an Mx1-Deficient Mouse Model.

IF 4.9 2区 医学 Q1 INFECTIOUS DISEASES International Journal of Antimicrobial Agents Pub Date : 2025-03-11 DOI:10.1016/j.ijantimicag.2025.107491
A Lozhkov, O Dobrovolskaya, E Romanovskaya-Romanko, S Shishlyannikov, E Elpaeva, A Garshinina, Y Zabrodskaya, A Shaldzhyan, V Egorov, A Vasin
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Abstract

Type III interferons (IFNs) are regarded as safe and effective preventive agents for viral infections of the respiratory tract. The antiviral effects of type I and III IFNs are mediated through the induction of interferon-stimulated genes (ISGs), the variability of which influences the course of the disease and an individual's susceptibility to viruses. The effectiveness of the preventive use of type III IFNs in patients with polymorphisms in critical antiviral ISGs is particularly relevant. In this study, we utilized Balb/c mice deficient in the Mx1 gene as model organisms. Type III IFNs demonstrated a protective effect against infection with the mouse-adapted pandemic strain of influenza A virus (IAV), A/California/07/09 (H1N1pdm09). A single intranasal administration of IFN-λ protected mice from weight loss, reduced the level of viral nucleoprotein in lung homogenates, and significant differences in survival curves were also observed. In the case of mixed infection (sequential infection with IAV at a sublethal dose and Staphylococcus aureus), a single intranasal administration of IFN-λ was associated with a decrease in bacterial load in the lungs, and minimal weight loss was observed in the mice. Thus, the study demonstrated that IFN-λ can have a protective effect in Mx1-deficient Balb/c mice. These data support the universality of type III IFN use, suggesting that these preventive agents can be effective even in patients with a suboptimal genetic background.

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CiteScore
21.60
自引率
0.90%
发文量
176
审稿时长
36 days
期刊介绍: The International Journal of Antimicrobial Agents is a peer-reviewed publication offering comprehensive and current reference information on the physical, pharmacological, in vitro, and clinical properties of individual antimicrobial agents, covering antiviral, antiparasitic, antibacterial, and antifungal agents. The journal not only communicates new trends and developments through authoritative review articles but also addresses the critical issue of antimicrobial resistance, both in hospital and community settings. Published content includes solicited reviews by leading experts and high-quality original research papers in the specified fields.
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Exploring the Protective Role of Recombinant Type III Interferons in Respiratory Infections: Insights from an Mx1-Deficient Mouse Model. Comparing the Knowledge, Attitudes, and Practices of Antibiotic Use and Antimicrobial Resistance for Cats and/or Dogs amongst Pet Owners in Singapore: A Cross-sectional Study. Genetic characterization of extensively drug-resistant blaCTX-M-27Shigella sonnei clusters among men who have sex with men in a region of northern Spain. Title Page & Editorial Board In reply to the Letter to Editor regarding 'Renal function and its impact on the concentration of ceftazidime-avibactam: A cross-sectional study'.
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