Neurological Injury in Comatose Patients Following Substance-Use-Related Out-of-Hospital Cardiac Arrest: A Retrospective Cohort Study in a Safety Net Hospital.

IF 3.1 3区 医学 Q2 CLINICAL NEUROLOGY Neurocritical Care Pub Date : 2025-03-13 DOI:10.1007/s12028-025-02229-w
Jonathan J Shih, Matheus Otero, Shital Gandhi, Jason Talbott, Bo Zhou, Jeffrey R Vitt, Neel S Singhal, Dominica Randazzo, Aaron Scheffler, J Claude Hemphill, Edilberto Amorim
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Abstract

Background: Substance-use-related cardiac arrest (SURCA) is a public health crisis, contributing to high mortality and severe neurological disability, particularly affecting young adults. This study aims to characterize the demographic and multimodal neurological prognostication features of patients with SURCA.

Methods: This retrospective study included patients with out-of-hospital cardiac arrest who presented to an urban academic safety net hospital between July 2016 and April 2022 and were comatose on admission. Patients with SURCA were identified through toxicology screening. Data on demographics, cardiac arrest characteristics, and multimodal neurological prognostication were collected. Poor neurological outcome was defined as a Cerebral Performance Category score of 3-5 at hospital discharge. Logistic regression was used to identify factors associated with poor neurological outcomes.

Results: Among 253 patients, 99 (39%) were classified as having SURCA, with 67 testing positive for stimulants and 56 testing positive for opioids. Patients with SURCA were younger (49 vs. 66 years, p < 0.001), less likely to have a witnessed cardiac arrest (56% vs. 71%, p = 0.01), and more likely to present with nonshockable rhythms (88% vs. 73%, p < 0.001). Electroencephalogram (EEG) monitoring in the SURCA cohort revealed a higher incidence of generalized periodic discharges (54% vs. 35%, p = 0.02) and electrographic seizures (28% vs. 13%, p = 0.02). Outcomes were similar between SURCA and non-SURCA groups; 86% of patients with SURCA had poor neurological outcomes, with 67% not surviving to discharge, compared to 88% and 69% of patients with non-SURCA, respectively. Nonshockable rhythms and older age were associated with poor neurological outcomes, but SURCA was not.

Conclusions: SURCA is common and is frequently associated with poor neurological outcomes despite affecting younger patients. A higher incidence of seizures and generalized periodic discharges on EEG was observed with SURCA; therefore, validation of this finding in larger multicenter cohorts is warranted. Public health interventions to improve bystander resuscitation education in populations at risk for SURCA may improve outcomes in this vulnerable population.

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来源期刊
Neurocritical Care
Neurocritical Care 医学-临床神经学
CiteScore
7.40
自引率
8.60%
发文量
221
审稿时长
4-8 weeks
期刊介绍: Neurocritical Care is a peer reviewed scientific publication whose major goal is to disseminate new knowledge on all aspects of acute neurological care. It is directed towards neurosurgeons, neuro-intensivists, neurologists, anesthesiologists, emergency physicians, and critical care nurses treating patients with urgent neurologic disorders. These are conditions that may potentially evolve rapidly and could need immediate medical or surgical intervention. Neurocritical Care provides a comprehensive overview of current developments in intensive care neurology, neurosurgery and neuroanesthesia and includes information about new therapeutic avenues and technological innovations. Neurocritical Care is the official journal of the Neurocritical Care Society.
期刊最新文献
Neurological Injury in Comatose Patients Following Substance-Use-Related Out-of-Hospital Cardiac Arrest: A Retrospective Cohort Study in a Safety Net Hospital. Correction: Predisposing Factors of Progression from Refractory Status Epilepticus to Super-Refractory Status Epilepticus in ICU-Admitted Patients: Multicenter Retrospective Cohort Study in a Resource-Limited Setting. Inhibition of C3a/C3aR by SB290157 Attenuates Neuroinflammation via PKC/P38/NLRP3 Signaling Pathway After Intracerebral Hemorrhage. Anticoagulant Therapy for Cerebral Venous Sinus Thrombosis: A Propensity Score Matching Study and Inverse Probability Weighting. Evolution of EEG Findings in Patients with Acute Brain Injury.
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