Dietary Sea buckthorn during pregnancy reverses offspring obesity by alleviating BAT dysfunction

IF 3.8 2区 农林科学 Q2 FOOD SCIENCE & TECHNOLOGY Journal of Functional Foods Pub Date : 2025-03-15 DOI:10.1016/j.jff.2025.106720
Lin Liang , Yu Wang , Haoran Chen , Jianrong Huo , Shilong Yu , Junxing Zhao
{"title":"Dietary Sea buckthorn during pregnancy reverses offspring obesity by alleviating BAT dysfunction","authors":"Lin Liang ,&nbsp;Yu Wang ,&nbsp;Haoran Chen ,&nbsp;Jianrong Huo ,&nbsp;Shilong Yu ,&nbsp;Junxing Zhao","doi":"10.1016/j.jff.2025.106720","DOIUrl":null,"url":null,"abstract":"<div><div>Sea buckthorn (SB) berries, which are non-toxic, contain diverse bioactive substances with high nutritional value and beneficial medicinal properties. This study aims to explore the effects of maternal dietary SB during pregnancy and lactation on high-fat diet (HFD) induced obesity in offspring. The results showed that maternal SB intake reduced offspring body weight and fat mass, and improved both glucose tolerance and insulin sensitivity. Furthermore, offspring of dams fed SB exhibited lower expression of inflammatory response factors, such as IL-6, IL-10, and TNF-α, and higher energy metabolism in BAT to resist the cold environment than the descendants of only HFD-fed dams. Meanwhile, markers for BAT were dramatically upregulated in offspring of HFDSB-fed dams. Finally, dietary SB restored the number of functional mitochondria by increasing PKM2 and FASN expression. Taken together, this study reveals a novel approach for alleviating offspring obesity induced by HFD in terms of maternal SB supplementation.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"127 ","pages":"Article 106720"},"PeriodicalIF":3.8000,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Functional Foods","FirstCategoryId":"97","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1756464625000623","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Sea buckthorn (SB) berries, which are non-toxic, contain diverse bioactive substances with high nutritional value and beneficial medicinal properties. This study aims to explore the effects of maternal dietary SB during pregnancy and lactation on high-fat diet (HFD) induced obesity in offspring. The results showed that maternal SB intake reduced offspring body weight and fat mass, and improved both glucose tolerance and insulin sensitivity. Furthermore, offspring of dams fed SB exhibited lower expression of inflammatory response factors, such as IL-6, IL-10, and TNF-α, and higher energy metabolism in BAT to resist the cold environment than the descendants of only HFD-fed dams. Meanwhile, markers for BAT were dramatically upregulated in offspring of HFDSB-fed dams. Finally, dietary SB restored the number of functional mitochondria by increasing PKM2 and FASN expression. Taken together, this study reveals a novel approach for alleviating offspring obesity induced by HFD in terms of maternal SB supplementation.

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
求助全文
约1分钟内获得全文 去求助
来源期刊
Journal of Functional Foods
Journal of Functional Foods FOOD SCIENCE & TECHNOLOGY-
CiteScore
9.60
自引率
1.80%
发文量
428
审稿时长
76 days
期刊介绍: Journal of Functional Foods continues with the same aims and scope, editorial team, submission system and rigorous peer review. We give authors the possibility to publish their top-quality papers in a well-established leading journal in the food and nutrition fields. The Journal will keep its rigorous criteria to screen high impact research addressing relevant scientific topics and performed by sound methodologies. The Journal of Functional Foods aims to bring together the results of fundamental and applied research into healthy foods and biologically active food ingredients. The Journal is centered in the specific area at the boundaries among food technology, nutrition and health welcoming papers having a good interdisciplinary approach. The Journal will cover the fields of plant bioactives; dietary fibre, probiotics; functional lipids; bioactive peptides; vitamins, minerals and botanicals and other dietary supplements. Nutritional and technological aspects related to the development of functional foods and beverages are of core interest to the journal. Experimental works dealing with food digestion, bioavailability of food bioactives and on the mechanisms by which foods and their components are able to modulate physiological parameters connected with disease prevention are of particular interest as well as those dealing with personalized nutrition and nutritional needs in pathological subjects.
期刊最新文献
Glycine soja extract alleviates muscle atrophy and inflammatory factors in sciatic nerve injury rats and prevents protein degradation in C2C12 myoblasts Dietary Sea buckthorn during pregnancy reverses offspring obesity by alleviating BAT dysfunction A standardized chamuangone enriched extract shows anticancer efficacy in allograft models of metastatic breast cancer Sinapic acid alleviates kidney injury of hyperuricemia mice by inhibiting ERK1/2-mediated apoptosis of renal tubular epithelial cells γ-Glutamylcysteine suppresses epithelial-mesenchymal transition in lens epithelial cells to ameliorate diabetic cataract through regulating TGF-β2 and AMPK-related signaling pathways
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1