{"title":"Prevalence of malaria and Schistosoma mansoni coinfection in sub Saharan Africa: A systematic review and meta-analysis","authors":"Wagaw Abebe , Birhanu Kassanew , Tadesse Misganaw , Agenagnew Ashagre , Getinet Kumie , Marye Nigatie , Yalewayker Gashaw , Ephrem Tamrat , Dagmawi Woldesenbet , Alembante Bazezew","doi":"10.1016/j.parepi.2025.e00422","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Malaria and schistosomiasis are two parasite illnesses that share transmission sites in distinct tropical climates. Malaria-schistosomiasis coinfection is widespread in Africa. Also, malaria and <em>Schistosoma mansoni</em> coinfection cause exacerbation of health consequences and co-morbidities. However, there is limited pooled data on the prevalence of malaria and <em>Schistosoma mansoni</em> coinfection in sub-Saharan Africa.</div></div><div><h3>Objective</h3><div>This systemic review and meta-analysis aimed to assess the prevalence of malaria and <em>Schistosoma mansoni</em> coinfection in sub-Saharan Africa.</div></div><div><h3>Method</h3><div>Systematic search on PubMed, Scopus, Google Scholar, and Science Direct was used to identify relevant studies following reviews and meta-analysis guidelines. A total of eighteen relevant articles on the prevalence of malaria and <em>Schistosoma mansoni</em> coinfection were identified for final systematic review and meta-analysis. Extracted data was analyzed using STATA software version 17.0. The absence or presence of publication bias was assessed using Egger's test. Heterogeneity across studies was checked by I<sup>2</sup> statistics; if the I<sup>2</sup> value was ≥50 %, significant heterogeneity was considered and subgroup analysis was done.</div></div><div><h3>Results</h3><div>A total of 18 studies were included for this systematic review and meta-analysis. From this meta-analysis, the pooled prevalence of malaria and <em>Schistosoma mansoni</em> coinfection was 17.39 % (95 % CI: 5.94–28.84). There was significant heterogeneity in prevalence of coinfection, with I<sup>2</sup> values greater than or equal to 99.97 % at <em>P</em> = 0.00. The subgroup analysis based on year of publication showed that the pooled prevalence of malaria and <em>Schistosoma mansoni</em> coinfection in studies conducted 2014–2018 was 20.73 % (95 % CI: 0.66–40.80), while it was 14.68 % (95 % CI: 1.02–28.34) in studies conducted 2019–2024. On the other hand, subgroup analysis on diagnostic techniques showed significant differences in the pooled prevalence of malaria and <em>Schistosoma mansoni</em> coinfection.</div></div><div><h3>Conclusions</h3><div>This systematic review and meta-analysis showed that malaria and <em>Schistosoma mansoni</em> coinfection are prevalent in sub-Saharan Africa.This highlights the region's major challenges in controlling malaria and <em>Schistosoma mansoni</em> coinfections.To ensure the efficiency of coinfections control and treatment, regular monitoring, identification, and reduction of the prevalence of malaria and <em>Schistosoma mansoni</em> coinfection must be maintained. Furthermore, cooperative efforts at local, countrywide, and global levels are necessary to address the multifaceted factors causal to malaria-<em>S.mansoni</em> coinfection.</div></div>","PeriodicalId":37873,"journal":{"name":"Parasite Epidemiology and Control","volume":"29 ","pages":"Article e00422"},"PeriodicalIF":2.0000,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Parasite Epidemiology and Control","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405673125000157","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0
Abstract
Background
Malaria and schistosomiasis are two parasite illnesses that share transmission sites in distinct tropical climates. Malaria-schistosomiasis coinfection is widespread in Africa. Also, malaria and Schistosoma mansoni coinfection cause exacerbation of health consequences and co-morbidities. However, there is limited pooled data on the prevalence of malaria and Schistosoma mansoni coinfection in sub-Saharan Africa.
Objective
This systemic review and meta-analysis aimed to assess the prevalence of malaria and Schistosoma mansoni coinfection in sub-Saharan Africa.
Method
Systematic search on PubMed, Scopus, Google Scholar, and Science Direct was used to identify relevant studies following reviews and meta-analysis guidelines. A total of eighteen relevant articles on the prevalence of malaria and Schistosoma mansoni coinfection were identified for final systematic review and meta-analysis. Extracted data was analyzed using STATA software version 17.0. The absence or presence of publication bias was assessed using Egger's test. Heterogeneity across studies was checked by I2 statistics; if the I2 value was ≥50 %, significant heterogeneity was considered and subgroup analysis was done.
Results
A total of 18 studies were included for this systematic review and meta-analysis. From this meta-analysis, the pooled prevalence of malaria and Schistosoma mansoni coinfection was 17.39 % (95 % CI: 5.94–28.84). There was significant heterogeneity in prevalence of coinfection, with I2 values greater than or equal to 99.97 % at P = 0.00. The subgroup analysis based on year of publication showed that the pooled prevalence of malaria and Schistosoma mansoni coinfection in studies conducted 2014–2018 was 20.73 % (95 % CI: 0.66–40.80), while it was 14.68 % (95 % CI: 1.02–28.34) in studies conducted 2019–2024. On the other hand, subgroup analysis on diagnostic techniques showed significant differences in the pooled prevalence of malaria and Schistosoma mansoni coinfection.
Conclusions
This systematic review and meta-analysis showed that malaria and Schistosoma mansoni coinfection are prevalent in sub-Saharan Africa.This highlights the region's major challenges in controlling malaria and Schistosoma mansoni coinfections.To ensure the efficiency of coinfections control and treatment, regular monitoring, identification, and reduction of the prevalence of malaria and Schistosoma mansoni coinfection must be maintained. Furthermore, cooperative efforts at local, countrywide, and global levels are necessary to address the multifaceted factors causal to malaria-S.mansoni coinfection.
期刊介绍:
Parasite Epidemiology and Control is an Open Access journal. There is an increasing amount of research in the parasitology area that analyses the patterns, causes, and effects of health and disease conditions in defined populations. This epidemiology of parasite infectious diseases is predominantly studied in human populations but also spans other major hosts of parasitic infections and as such this journal will have a broad remit. We will focus on the major areas of epidemiological study including disease etiology, disease surveillance, drug resistance and geographical spread and screening, biomonitoring, and comparisons of treatment effects in clinical trials for both human and other animals. We will also look at the epidemiology and control of vector insects. The journal will also cover the use of geographic information systems (Epi-GIS) for epidemiological surveillance which is a rapidly growing area of research in infectious diseases. Molecular epidemiological approaches are also particularly encouraged.