Behavioral and endocrine effects of early-life exposure to etonogestrel in zebrafish

IF 3.4 3区医学 Q2 PHARMACOLOGY & PHARMACY Toxicology and applied pharmacology Pub Date : 2025-05-01 Epub Date: 2025-03-13 DOI:10.1016/j.taap.2025.117300

Amanda Carolina Cole Varela , Lisiane Siqueira , Milena Fortuna , Suelen Mendonça Soares , Natália Freddo , Ísis Piasson Barletto , Maíra Souza Ariotti , Milena Zanoello Bertuol , Gabriéla Witkowski Rutikoski , Cecília Mazutti Andrade , Leonardo José Gil Barcellos

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Abstract

Progestin use as a contraceptive has increased exponentially in the last few decades, as has its disposal in the environment. These synthetic hormones can impair the physiology and behavior of non-target organisms, such as fish. In this study, we evaluated the effects of exposure to an environmentally relevant concentration of etonogestrel (ETO, 3.2 ng L⁻¹) on the behavior and endocrine system of zebrafish (Danio rerio) larvae. We found that ETO caused anxiogenic-like behavior in larvae, as demonstrated by the open-field and light-dark tests. The exposed larvae also presented an increase in whole-body cortisol levels. These changes may lead to an ecological imbalance, emphasizing the risk of early exposure to progestins in the environment.

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斑马鱼早期接触依诺孕酮对行为和内分泌的影响

在过去的几十年里，黄体酮作为一种避孕药的使用呈指数增长，其在环境中的处置也呈指数增长。这些合成激素可以损害非目标生物（如鱼类）的生理和行为。在这项研究中，我们评估了暴露于环境相关浓度的依托孕酮（ETO, 3.2 ng L−1）对斑马鱼（Danio rerio）幼虫行为和内分泌系统的影响。我们发现ETO引起了幼虫的焦虑样行为，这在露天和光暗试验中得到了证实。暴露的幼虫也表现出全身皮质醇水平的增加。这些变化可能导致生态失衡，强调在环境中过早接触黄体酮的风险。

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来源期刊

Toxicology and applied pharmacology 医学-毒理学

CiteScore

6.80

自引率

2.60%

发文量

309

审稿时长

32 days

期刊介绍： Toxicology and Applied Pharmacology publishes original scientific research of relevance to animals or humans pertaining to the action of chemicals, drugs, or chemically-defined natural products. Regular articles address mechanistic approaches to physiological, pharmacologic, biochemical, cellular, or molecular understanding of toxicologic/pathologic lesions and to methods used to describe these responses. Safety Science articles address outstanding state-of-the-art preclinical and human translational characterization of drug and chemical safety employing cutting-edge science. Highly significant Regulatory Safety Science articles will also be considered in this category. Papers concerned with alternatives to the use of experimental animals are encouraged. Short articles report on high impact studies of broad interest to readers of TAAP that would benefit from rapid publication. These articles should contain no more than a combined total of four figures and tables. Authors should include in their cover letter the justification for consideration of their manuscript as a short article.