Israa M.S. AL-Kadmy , Nadal A. Al-Saryi , Istabreq Muhammed Ali Salman , Eman Thamer Garallah , Sarah Naji Aziz , Sawsan Sajid Al-Jubori , Eman Natiq Naji , Eman Alhomaidi , Salam S. Alsharari , Yasmin N. Ramadan , Helal F. Hetta
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引用次数: 0
Abstract
Background and aim
Serratia marcescens (S. marcescens) poses a growing threat to ICU patients, particularly due to its multidrug resistance (MDR). This study evaluates the prevalence of antimicrobial resistance and associated genes in ICU isolates in Baghdad, highlighting clinical implications.
Methodology
A total of 101 isolates were analyzed using biochemical and molecular techniques. Antibiotic susceptibility and resistance gene profiles were assessed via standardized testing and PCR.
Results
Among 101 S. marcescens isolates, 71 were MDR. Universal resistance to beta-lactams was noted, with key genes (blaCTX-M and blaSHV) detected in all isolates, while blaCMY and blaTEM were present in approximately 95 % and 89 % of isolates. Additionally, carbapenemase genes were detected in up to 90 % of isolates, underscoring a significant resistance burden.
Conclusion
The study highlights the critical threat posed by multidrug-resistant S. marcescens in ICU settings, emphasizing the need for improved infection control and therapeutic innovation.
Gene ReportsBiochemistry, Genetics and Molecular Biology-Genetics
CiteScore
3.30
自引率
7.70%
发文量
246
审稿时长
49 days
期刊介绍:
Gene Reports publishes papers that focus on the regulation, expression, function and evolution of genes in all biological contexts, including all prokaryotic and eukaryotic organisms, as well as viruses. Gene Reports strives to be a very diverse journal and topics in all fields will be considered for publication. Although not limited to the following, some general topics include: DNA Organization, Replication & Evolution -Focus on genomic DNA (chromosomal organization, comparative genomics, DNA replication, DNA repair, mobile DNA, mitochondrial DNA, chloroplast DNA). Expression & Function - Focus on functional RNAs (microRNAs, tRNAs, rRNAs, mRNA splicing, alternative polyadenylation) Regulation - Focus on processes that mediate gene-read out (epigenetics, chromatin, histone code, transcription, translation, protein degradation). Cell Signaling - Focus on mechanisms that control information flow into the nucleus to control gene expression (kinase and phosphatase pathways controlled by extra-cellular ligands, Wnt, Notch, TGFbeta/BMPs, FGFs, IGFs etc.) Profiling of gene expression and genetic variation - Focus on high throughput approaches (e.g., DeepSeq, ChIP-Seq, Affymetrix microarrays, proteomics) that define gene regulatory circuitry, molecular pathways and protein/protein networks. Genetics - Focus on development in model organisms (e.g., mouse, frog, fruit fly, worm), human genetic variation, population genetics, as well as agricultural and veterinary genetics. Molecular Pathology & Regenerative Medicine - Focus on the deregulation of molecular processes in human diseases and mechanisms supporting regeneration of tissues through pluripotent or multipotent stem cells.