Ultrasonic-assisted extraction of flavonoids from Amomum villosum Lour. Using natural deep eutectic solvent: Process optimization, comparison, identification, and bioactivity

IF 8.7 1区 化学 Q1 ACOUSTICS Ultrasonics Sonochemistry Pub Date : 2025-03-12 DOI:10.1016/j.ultsonch.2025.107304
Zijing Peng , Yingchao Wang , Wenfeng Li , Bingjinfeng Zhan , Longping Zhu , Depo Yang , Ge Li , Lixia Zhang , Zhimin Zhao
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Abstract

Amomum villosum Lour. (A. villosum) is widely utilized in culinary and medicinal contexts due to its rich diversity of bioactive compounds. In this study, an ultrasonic-assisted extraction (UAE) method using a natural deep eutectic solvent (NaDES) was employed to extract flavonoids from A. villosum. The NaDES composed of betaine and glycerol (Bet-Gly) exhibited effective performance as an extraction solvent, as evidenced by its high efficiency. Optimal extraction conditions (water content: 30 %, solid–liquid ratio: 1:20 g/mL, temperature: 70 °C, ultrasonic power: 85 % P, time: 30 mins) were established via single-factor experiments. The maximum total flavonoid content (TFC) of 82.22 ± 0.39 mg rutin equivalent per gram dry weight (mg Rut/g DW) was achieved under optimized conditions. Comparative studies revealed that the UAE-NaDES method afforded higher TFC and DPPH radical scavenging activity values, broader flavonoid diversity, and demonstrated a better capacity to stabilize them compared to conventional solutions. Furthermore, NaDES exhibited favorable biocompatibility properties, and the resulting extract displayed remarkable anti-inflammatory and anti-cancer effects. These findings demonstrate that NaDES is an efficient solvent for flavonoids extraction from A. villosum, with potential applications in food and pharmaceutical industries, thereby minimizing solvent removal steps.
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来源期刊
Ultrasonics Sonochemistry
Ultrasonics Sonochemistry 化学-化学综合
CiteScore
15.80
自引率
11.90%
发文量
361
审稿时长
59 days
期刊介绍: Ultrasonics Sonochemistry stands as a premier international journal dedicated to the publication of high-quality research articles primarily focusing on chemical reactions and reactors induced by ultrasonic waves, known as sonochemistry. Beyond chemical reactions, the journal also welcomes contributions related to cavitation-induced events and processing, including sonoluminescence, and the transformation of materials on chemical, physical, and biological levels. Since its inception in 1994, Ultrasonics Sonochemistry has consistently maintained a top ranking in the "Acoustics" category, reflecting its esteemed reputation in the field. The journal publishes exceptional papers covering various areas of ultrasonics and sonochemistry. Its contributions are highly regarded by both academia and industry stakeholders, demonstrating its relevance and impact in advancing research and innovation.
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