The developing visual system: A building block on the path to autism

Abstract

Longitudinal neuroimaging studies conducted over the past decade provide evidence of atypical visual system development in the first years of life in autism spectrum disorder (ASD). Findings from genomic analyses, family studies, and postmortem investigations suggest that changes in the visual system in ASD are linked to genetic factors, making the visual system an important neural phenotype along the path from genes to behavior that deserves further study. This article reviews what is known about the developing visual system in ASD in the first years of life; it also explores the potential canalizing role that atypical visual system maturation may have in the emergence of ASD by placing findings in the context of developmental cascades involving brain development, attention, and social and cognitive development. Critical gaps in our understanding of human visual system development are discussed, and future research directions are proposed to improve our understanding of ASD as a complex neurodevelopmental disorder with origins in early brain development.