Quantitative ultrasound and photoacoustic assessments of red blood cell aggregation in the human radial artery

IF 7.1 1区医学 Q1 ENGINEERING, BIOMEDICAL Photoacoustics Pub Date : 2025-03-13 DOI:10.1016/j.pacs.2025.100711

Taehoon Bok , Eno Hysi , Michael C. Kolios

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Abstract

We develop concurrent US and photoacoustic (PA) imaging to characterize structural/physiological impact of in-vivo red blood cell (RBC) aggregation. PA images at 700/800/900 nm were collected from the radial arteries of 12 participants across age groups (20 s/30 s/40 s) alongside US images (21 MHz, VevoLAZR). RBC aggregate size was estimated from US-derived structure-factor-size-estimation (D_SFSE) and PA-derived spectral-slope (SS), along with oxygen saturation (sO₂). At peak systole (PS), D_SFSE^PS and SS^PS approximated 1 RBC and −0.1 dB/MHz, respectively, across all ages, with sO₂^PS values of 97.1 %, 94.7 %, and 93.0 % for each group. At end diastole (ED), D_SFSE^ED, SS^ED and sO₂^ED values were 2.6, 3.4, and 4.7 RBCs; −0.7, −0.9, and −1.2 dB/MHz; and 98.7 %, 97.2 %, and 96.7 %, respectively. Differences between SS^ED and SS^PS (δSS) and sO₂^ED and sO₂^PS (δsO₂) increased with age, indicating aging-related increases in DSFSE and δSS, as well as decreases in sO₂^PS and sO₂^ED.

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我们开发了同步 US 和光声（PA）成像技术，以描述体内红细胞（RBC）聚集对结构/生理的影响。在 US 图像（21 MHz，VevoLAZR）的同时，我们从 12 名不同年龄组的参与者的桡动脉中采集了波长为 700/800/900 nm 的 PA 图像（20 秒/30 秒/40 秒）。根据 US 导出的结构因子尺寸估计值（DSFSE）和 PA 导出的光谱斜率（SS）以及血氧饱和度（sO2）估算 RBC 聚集大小。在收缩高峰期（PS），所有年龄组的 DSFSEPS 和 SSPS 分别接近 1 RBC 和 -0.1 dB/MHz，各组的 sO2PS 值分别为 97.1%、94.7% 和 93.0%。在舒张末期（ED），DSFSEED、SSED 和 sO2ED 值分别为 2.6、3.4 和 4.7 RBCs；-0.7、-0.9 和 -1.2 dB/MHz；以及 98.7 %、97.2 % 和 96.7 %。随着年龄的增长，SSED 和 SSPS（δSS）以及 sO2ED 和 sO2PS（δsO2）之间的差异也随之增大，这表明 DSFSE 和 δSS 会随着年龄的增长而增大，而 sO2PS 和 sO2ED 则会随着年龄的增长而减小。

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来源期刊

Photoacoustics Physics and Astronomy-Atomic and Molecular Physics, and Optics

CiteScore

11.40

自引率

16.50%

发文量

审稿时长

53 days

期刊介绍： The open access Photoacoustics journal (PACS) aims to publish original research and review contributions in the field of photoacoustics-optoacoustics-thermoacoustics. This field utilizes acoustical and ultrasonic phenomena excited by electromagnetic radiation for the detection, visualization, and characterization of various materials and biological tissues, including living organisms. Recent advancements in laser technologies, ultrasound detection approaches, inverse theory, and fast reconstruction algorithms have greatly supported the rapid progress in this field. The unique contrast provided by molecular absorption in photoacoustic-optoacoustic-thermoacoustic methods has allowed for addressing unmet biological and medical needs such as pre-clinical research, clinical imaging of vasculature, tissue and disease physiology, drug efficacy, surgery guidance, and therapy monitoring. Applications of this field encompass a wide range of medical imaging and sensing applications, including cancer, vascular diseases, brain neurophysiology, ophthalmology, and diabetes. Moreover, photoacoustics-optoacoustics-thermoacoustics is a multidisciplinary field, with contributions from chemistry and nanotechnology, where novel materials such as biodegradable nanoparticles, organic dyes, targeted agents, theranostic probes, and genetically expressed markers are being actively developed. These advanced materials have significantly improved the signal-to-noise ratio and tissue contrast in photoacoustic methods.