Case report: single-cell transcriptome sequencing reveals the clonal origin of mature plasmacytoid dendritic cell proliferation in early T-cell precursor lymphoblastic leukemia.
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引用次数: 0
Abstract
Introduction: Mature plasmacytoid dendritic cell proliferation (MPDCP) is generally considered to be associated with myeloid neoplasms. To date, case reports of MPDCP associated with lymphoid malignancies are exceedingly rare.
Case report: Herein, we report the case of a 69-year-old male who presented with multiple enlarged preauricular, cervical, inguinal, and axillary lymph nodes. A comprehensive analysis, including morphology, immunophenotyping, and histopathology, confirmed a diagnosis of early T-cell precursor acute lymphoblastic leukemia with MPDCP. Single-cell RNA sequencing identified a transcriptional continuum between T-ALL blasts and pDCs, indicating a potential developmental relationship between these cell types. During the 9-month follow-up period, the patient survived and achieved complete remission.
Conclusion: This case highlights the presence of MPDCP in lymphoid malignancies and utilizes single-cell RNA sequencing technology to provide insights into the potential link between pDC and lymphocyte differentiation and development. However, further studies are needed to confirm these findings and explore their clinical implications.
期刊介绍:
Annals of Hematology covers the whole spectrum of clinical and experimental hematology, hemostaseology, blood transfusion, and related aspects of medical oncology, including diagnosis and treatment of leukemias, lymphatic neoplasias and solid tumors, and transplantation of hematopoietic stem cells. Coverage includes general aspects of oncology, molecular biology and immunology as pertinent to problems of human blood disease. The journal is associated with the German Society for Hematology and Medical Oncology, and the Austrian Society for Hematology and Oncology.