Predicting pathological tumor volume in prostate cancer lesions: A head-to-head comparison of micro-ultrasound vs. MRI.

IF 2.4 3区医学 Q3 ONCOLOGY Urologic Oncology-seminars and Original Investigations Pub Date : 2025-03-13 DOI:10.1016/j.urolonc.2025.02.015

Adrien Richemond, Max Peters, Sandy Schaer, Julien Dagher, Stefano La Rosa, Jade Matthey, Naik Vietti-Violi, Beat Roth, Ilaria Lucca, Massimo Valerio, Arnas Rakauskas

{"title":"Predicting pathological tumor volume in prostate cancer lesions: A head-to-head comparison of micro-ultrasound vs. MRI.","authors":"Adrien Richemond, Max Peters, Sandy Schaer, Julien Dagher, Stefano La Rosa, Jade Matthey, Naik Vietti-Violi, Beat Roth, Ilaria Lucca, Massimo Valerio, Arnas Rakauskas","doi":"10.1016/j.urolonc.2025.02.015","DOIUrl":null,"url":null,"abstract":"Background and objective: Our objective was to evaluate the agreement between micro-ultrasound, MRI and pathological tumor and prostate volume.Methods: Retrospective analysis of consecutive prostate cancer patients with MRI and micro-ultrasound diagnostic assessment who subsequently underwent radical prostatectomy. Tumor and prostate volume on micro-ultrasound and MRI imaging calculated by a dedicated software were compared to those of the prostatectomy specimen. Clinical, radiological, and pathological predictors of pathological tumor size were assessed.Results: 65 men with a total of 104 lesions in the final pathology were included. Median micro-ultrasound tumor size was 1.05 ml (IQR 0.35-2.65). On MRI T2WI, DWI and ADC sequences median tumor volume was 0.73 ml (IQR 0.34-1.94), 0.94 ml (IQR 0.38-2.09) and 0.86 ml (IQR 0.42-1.58), respectively. The pathological median tumor size was 1.2 ml (IQR 0.2-3.9). On average, micro-ultrasound underestimated pathological tumor volume by 0.15 ml (P < 0.01) while DWI, the most precise MRI sequence underestimated tumor size by 0.26 ml (P < 0.01). The MRI and micro-ultrasound underestimated the pathological prostate volume by 6 ml (P < 0.01) and 3 ml (P = 0.47), respectively.Conclusions: Both micro-ultrasound and MRI tend to slightly underestimate pathological tumor and prostate volume. Our study shows that both micro-ultrasound and MRI can be useful in the surgical planning although the underestimation of actual tumor size should be considered.","PeriodicalId":23408,"journal":{"name":"Urologic Oncology-seminars and Original Investigations","volume":" ","pages":""},"PeriodicalIF":2.4000,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Urologic Oncology-seminars and Original Investigations","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.urolonc.2025.02.015","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background and objective: Our objective was to evaluate the agreement between micro-ultrasound, MRI and pathological tumor and prostate volume.

Methods: Retrospective analysis of consecutive prostate cancer patients with MRI and micro-ultrasound diagnostic assessment who subsequently underwent radical prostatectomy. Tumor and prostate volume on micro-ultrasound and MRI imaging calculated by a dedicated software were compared to those of the prostatectomy specimen. Clinical, radiological, and pathological predictors of pathological tumor size were assessed.

Results: 65 men with a total of 104 lesions in the final pathology were included. Median micro-ultrasound tumor size was 1.05 ml (IQR 0.35-2.65). On MRI T2WI, DWI and ADC sequences median tumor volume was 0.73 ml (IQR 0.34-1.94), 0.94 ml (IQR 0.38-2.09) and 0.86 ml (IQR 0.42-1.58), respectively. The pathological median tumor size was 1.2 ml (IQR 0.2-3.9). On average, micro-ultrasound underestimated pathological tumor volume by 0.15 ml (P < 0.01) while DWI, the most precise MRI sequence underestimated tumor size by 0.26 ml (P < 0.01). The MRI and micro-ultrasound underestimated the pathological prostate volume by 6 ml (P < 0.01) and 3 ml (P = 0.47), respectively.

Conclusions: Both micro-ultrasound and MRI tend to slightly underestimate pathological tumor and prostate volume. Our study shows that both micro-ultrasound and MRI can be useful in the surgical planning although the underestimation of actual tumor size should be considered.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

背景和目的我们的目的是评估显微超声波、核磁共振成像和病理肿瘤与前列腺体积之间的一致性：方法：对接受磁共振成像和显微超声诊断评估并随后接受根治性前列腺切除术的连续前列腺癌患者进行回顾性分析。通过专用软件计算出的显微超声和核磁共振成像上的肿瘤和前列腺体积与前列腺切除术标本上的肿瘤和前列腺体积进行比较。对病理肿瘤大小的临床、放射学和病理学预测因素进行了评估：结果：共纳入 65 名男性，最终病理结果显示共有 104 个病灶。显微超声肿瘤大小中位数为 1.05 毫升（IQR 0.35-2.65）。核磁共振 T2WI、DWI 和 ADC 序列中位肿瘤体积分别为 0.73 毫升（IQR 0.34-1.94）、0.94 毫升（IQR 0.38-2.09）和 0.86 毫升（IQR 0.42-1.58）。病理中位肿瘤大小为 1.2 毫升（IQR 0.2-3.9）。显微超声检查平均低估了病理肿瘤体积 0.15 毫升（P 结论：显微超声检查和核磁共振检查都低估了病理肿瘤体积：显微超声和核磁共振成像都有轻微低估病理肿瘤和前列腺体积的倾向。我们的研究表明，显微超声波和磁共振成像在手术规划中都很有用，但应考虑到对实际肿瘤大小的低估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Urologic Oncology-seminars and Original Investigations 医学-泌尿学与肾脏学

CiteScore

4.80

自引率

3.70%

发文量

297

审稿时长

7.6 weeks

期刊介绍： Urologic Oncology: Seminars and Original Investigations is the official journal of the Society of Urologic Oncology. The journal publishes practical, timely, and relevant clinical and basic science research articles which address any aspect of urologic oncology. Each issue comprises original research, news and topics, survey articles providing short commentaries on other important articles in the urologic oncology literature, and reviews including an in-depth Seminar examining a specific clinical dilemma. The journal periodically publishes supplement issues devoted to areas of current interest to the urologic oncology community. Articles published are of interest to researchers and the clinicians involved in the practice of urologic oncology including urologists, oncologists, and radiologists.