Metabolic tumor parameters on 18F-FDG PET/CT can predict the expression of PD-L1 and prognosis in patients with fumarate hydratase-deficient renal cell carcinoma.
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引用次数: 0
Abstract
Objective: This study aimed to comprehensively evaluate the performance of fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) and investigate the association between metabolic parameters, programmed cell death ligand 1 (PD-L1) expression, and prognosis in patients with fumarate hydratase-deficient renal cell carcinoma (FHRCC).
Methods: Twenty-nine patients with FHRCC were prospectively enrolled from May 2020 to February 2023 for 18F-FDG PET/CT. The maximum standardized uptake value (SUVmax), peak standardized uptake value (SUVpeak), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) of primary/recurrent tumors were analyzed. The relationship between PET metabolic parameters, clinicopathological features and prognosis were evaluated.
Results: Primary/recurrent and metastatic lesions showed FDG avidity, without metabolic differences between them. In our analysis, SUVmax of whole body (WB-SUVmax), SUVpeak of whole body (WB-SUVpeak), MTV of whole body (WB-MTV), and TLG of whole body (WB-TLG) were associated with the expression of PD-L1. The optimal cut-off values of WB-SUVmax, WB-SUVpeak, WB-MTV, and WB-TLG for predicting positive PD-L1 expression were 9.86 (AUC 0.814), 6.92 (AUC 0.848), 19.61 cm3 (AUC 0.803), and 58.39 g (AUC 0.841), respectively. Survival analysis further demonstrated that patients with WB-SUVpeak ≥ 8.92 had shorter time to progression than those with WB-SUVpeak < 8.92 (11.0 mo vs. 21.0 mo, P = 0.047).
Conclusions: 18F-FDG PET/CT is effective in detecting FHRCC lesions due to their hypermetabolic nature. PET metabolic parameters can serve as predictors of positive PD-L1 expression, with higher values observed in FHRCC patients with positive PD-L1 expression. Additionally, WB-SUVpeak is a significant predictor of prognosis in patients with FHRCC.
期刊介绍：
Annals of Nuclear Medicine is an official journal of the Japanese Society of Nuclear Medicine. It develops the appropriate application of radioactive substances and stable nuclides in the field of medicine.
The journal promotes the exchange of ideas and information and research in nuclear medicine and includes the medical application of radionuclides and related subjects. It presents original articles, short communications, reviews and letters to the editor.
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