Persistent effects of early-life exposure to dibutyl phthalate on zebrafish: Immune system dysfunction via HPA axis

IF 10.3 1区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Environment International Pub Date : 2025-03-16 DOI:10.1016/j.envint.2025.109386
Yue Tao, Yanyan Gu, Haorui Wang, Guanyu Zhong, Aoxue Wang, Jianhua Qu, Jiayi Feng, Ying Zhang
{"title":"Persistent effects of early-life exposure to dibutyl phthalate on zebrafish: Immune system dysfunction via HPA axis","authors":"Yue Tao, Yanyan Gu, Haorui Wang, Guanyu Zhong, Aoxue Wang, Jianhua Qu, Jiayi Feng, Ying Zhang","doi":"10.1016/j.envint.2025.109386","DOIUrl":null,"url":null,"abstract":"The plasticizer dibutyl phthalate (DBP) is one of the common contaminants in the aquatic environment and has been verified to be detrimental to aquatic organisms. In this research, zebrafish was employed to explore the toxic mechanism of DBP at environmental concentrations. The findings indicated that DBP led to abnormal development of zebrafish larvae, encompassing an increase in heart rate and malformation rate, as well as a reduction in survival rate and hatching rate. DBP also induced HPA axis activation, increased glucocorticoid content and microglia activation in zebrafish larvae. Moreover, adult zebrafish in the early-life exposure and long-term exposure groups demonstrated anxiety-like and depression-like behaviors. RNA-seq analysis revealed that early embryonic exposure to DBP led to persistent damage in zebrafish that could not be recovered in adulthood. The HPA axis was more severely disorganized in males than in females, and sex-specific differences were also shown in immunotoxicity. It is speculated that the immune system disorder could partially attribute to the out-of-control HPA axis, while the activation of inflammatory cells and inflammatory factors will further exacerbate the situation of HPA axis dysregulation.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"24 1","pages":""},"PeriodicalIF":10.3000,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Environment International","FirstCategoryId":"93","ListUrlMain":"https://doi.org/10.1016/j.envint.2025.109386","RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

The plasticizer dibutyl phthalate (DBP) is one of the common contaminants in the aquatic environment and has been verified to be detrimental to aquatic organisms. In this research, zebrafish was employed to explore the toxic mechanism of DBP at environmental concentrations. The findings indicated that DBP led to abnormal development of zebrafish larvae, encompassing an increase in heart rate and malformation rate, as well as a reduction in survival rate and hatching rate. DBP also induced HPA axis activation, increased glucocorticoid content and microglia activation in zebrafish larvae. Moreover, adult zebrafish in the early-life exposure and long-term exposure groups demonstrated anxiety-like and depression-like behaviors. RNA-seq analysis revealed that early embryonic exposure to DBP led to persistent damage in zebrafish that could not be recovered in adulthood. The HPA axis was more severely disorganized in males than in females, and sex-specific differences were also shown in immunotoxicity. It is speculated that the immune system disorder could partially attribute to the out-of-control HPA axis, while the activation of inflammatory cells and inflammatory factors will further exacerbate the situation of HPA axis dysregulation.

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
求助全文
约1分钟内获得全文 去求助
来源期刊
Environment International
Environment International 环境科学-环境科学
CiteScore
21.90
自引率
3.40%
发文量
734
审稿时长
2.8 months
期刊介绍: Environmental Health publishes manuscripts focusing on critical aspects of environmental and occupational medicine, including studies in toxicology and epidemiology, to illuminate the human health implications of exposure to environmental hazards. The journal adopts an open-access model and practices open peer review. It caters to scientists and practitioners across all environmental science domains, directly or indirectly impacting human health and well-being. With a commitment to enhancing the prevention of environmentally-related health risks, Environmental Health serves as a public health journal for the community and scientists engaged in matters of public health significance concerning the environment.
期刊最新文献
Branched perfluorohexanesulfonic acid (PFHxS) and perfluoroheptanoic acid (PFHpA): ’Safer’ per- and polyfluoroalkyl substances (PFASs) alternatives for their effects on gut microbiota and metabolic function in children Associations between long-term air pollution exposure and mortality and cardiovascular morbidity: A comparison of mobility-integrated and residential-only exposure assessment Polycyclic aromatic hydrocarbon (PAH) exposure among European adults: Evidence from the HBM4EU aligned studies Serum biomonitoring of per- and polyfluoroalkyl substances (PFASs) in the adult population of Switzerland: Results from the pilot phase of the Swiss health study Persistent effects of early-life exposure to dibutyl phthalate on zebrafish: Immune system dysfunction via HPA axis
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1