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Exposure to polycyclic aromatic hydrocarbons and aging acceleration: Unraveling the underlying mechanisms and the role of AKT1 via integrative methods 暴露于多环芳烃和老化加速:通过综合方法揭示AKT1的潜在机制和作用
IF 11.8 1区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-08 DOI: 10.1016/j.envint.2026.110125
Xuejie Ding, Jiake Zhang, Ruyi Liang, Shijie Yang, Xiuquan Nie, Min Zhou, Weihong Chen
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引用次数: 0
Atmospheric microplastics in PM2.5 from 2010 to 2024 in Beijing: Type-specific trends and driving factors 2010 - 2024年北京PM2.5大气微塑料含量:特定类型趋势和驱动因素
IF 11.8 1区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-07 DOI: 10.1016/j.envint.2026.110135
Pengju Liu, Guangjie Zheng, Wenchuo Yao, Wenhua Wang, Dongbin Wang, Jingkun Jiang, Longyi Shao, Lidia Morawska, Kebin He
Atmospheric microplastics in respirable PM2.5 (MP2.5) have attracted widespread attention, yet their characteristics, major sources, and factors influencing their emission remain poorly understood. We present the first long-term (2010–2024) observation of atmospheric MP2.5 in Beijing, quantified with pyrolysis–gas chromatography / mass spectrometry. Our investigation of type-specific trends and driving factors revealed an overall increasing trend in MP2.5 concentration, with an average level of 264 ng/m3 and a peak of 417.6 ng/m3 in 2021. The distinct trends of MP2.5 and PM2.5 concentrations suggest that their major sources differ, necessitating different regulation measures for each. PVC (polyvinyl chloride), PS (polystyrene), PP (polypropylene), PE (polyethylene), and PA66 (polyamide 66) are the predominant types of MP2.5, differing markedly from the pattern in dustfall or total suspended particulate matter. PS, PP, and PP correlated positively with express delivery volume and total retail sales of consumer goods, implicating packaging material as a potential major source. PA66 and PVC, which are widely used in disposable medical supplies such as protective suits, responded sensitively to the COVID-19 pandemic. Our findings reveal that socioeconomic activities strongly influence the long-term evolution of MP2.5 patterns, and provide a scientific basis for related risk assessments
{"title":"Atmospheric microplastics in PM2.5 from 2010 to 2024 in Beijing: Type-specific trends and driving factors","authors":"Pengju Liu, Guangjie Zheng, Wenchuo Yao, Wenhua Wang, Dongbin Wang, Jingkun Jiang, Longyi Shao, Lidia Morawska, Kebin He","doi":"10.1016/j.envint.2026.110135","DOIUrl":"https://doi.org/10.1016/j.envint.2026.110135","url":null,"abstract":"Atmospheric microplastics in respirable PM<sub>2.5</sub> (MP<sub>2.5</sub>) have attracted widespread attention, yet their characteristics, major sources, and factors influencing their emission remain poorly understood. We present the first long-term (2010–2024) observation of atmospheric MP<sub>2.5</sub> in Beijing, quantified with pyrolysis–gas chromatography / mass spectrometry. Our investigation of type-specific trends and driving factors revealed an overall increasing trend in MP<sub>2.5</sub> concentration, with an average level of 264 ng/m<sup>3</sup> and a peak of 417.6 ng/m<sup>3</sup> in 2021. The distinct trends of MP<sub>2.5</sub> and PM<sub>2.5</sub> concentrations suggest that their major sources differ, necessitating different regulation measures for each. PVC (polyvinyl chloride), PS (polystyrene), PP (polypropylene), PE (polyethylene), and PA66 (polyamide 66) are the predominant types of MP<sub>2.5</sub>, differing markedly from the pattern in dustfall or total suspended particulate matter. PS, PP, and PP correlated positively with express delivery volume and total retail sales of consumer goods, implicating packaging material as a potential major source. PA66 and PVC, which are widely used in disposable medical supplies such as protective suits, responded sensitively to the COVID-19 pandemic. Our findings reveal that socioeconomic activities strongly influence the long-term evolution of MP<sub>2.5</sub> patterns, and provide a scientific basis for related risk assessments","PeriodicalId":308,"journal":{"name":"Environment International","volume":"31 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146129656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Health risk assessment of emerging PFOS substitute 8:2 Cl-PFESA: evidence from mouse spermatogenesis and derivation of a safe exposure threshold 新出现的全氟辛烷磺酸替代品8:2 cl -全氟辛烷磺酸的健康风险评估:来自小鼠精子发生的证据和安全暴露阈值的衍生
IF 11.8 1区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-07 DOI: 10.1016/j.envint.2026.110134
Ziwen An, Zheyuan Liu, Xiuli Zeng, Zexuan Jiang, Ziang Chen, Yiming Zhu, Longfei Li, Tianhao Sun, Chang Zheng, Xuehui Liu, Yi Liu, Zhenzhen Tan, Huicai Guo
{"title":"Health risk assessment of emerging PFOS substitute 8:2 Cl-PFESA: evidence from mouse spermatogenesis and derivation of a safe exposure threshold","authors":"Ziwen An, Zheyuan Liu, Xiuli Zeng, Zexuan Jiang, Ziang Chen, Yiming Zhu, Longfei Li, Tianhao Sun, Chang Zheng, Xuehui Liu, Yi Liu, Zhenzhen Tan, Huicai Guo","doi":"10.1016/j.envint.2026.110134","DOIUrl":"https://doi.org/10.1016/j.envint.2026.110134","url":null,"abstract":"","PeriodicalId":308,"journal":{"name":"Environment International","volume":"1 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146135424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Key role of nitrogen-containing organic species in haze formation and health implications: an ion mobility-analysis based study 含氮有机物种在雾霾形成和健康影响中的关键作用:一项基于离子迁移分析的研究
IF 11.8 1区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-07 DOI: 10.1016/j.envint.2026.110136
Mi Tian, Xinquan Zhao, Wei Zhang, Jinyitao Wang, Arthur W.H. Chan, Fumo Yang, Yang Chen, Shunyao Wang
{"title":"Key role of nitrogen-containing organic species in haze formation and health implications: an ion mobility-analysis based study","authors":"Mi Tian, Xinquan Zhao, Wei Zhang, Jinyitao Wang, Arthur W.H. Chan, Fumo Yang, Yang Chen, Shunyao Wang","doi":"10.1016/j.envint.2026.110136","DOIUrl":"https://doi.org/10.1016/j.envint.2026.110136","url":null,"abstract":"","PeriodicalId":308,"journal":{"name":"Environment International","volume":"47 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146135235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multi-omics reveals ferroptosis as a key mechanism in PM2.5-exacerbated periodontitis via gingival fibroblast damage 多组学揭示了铁上落是pm2.5通过牙龈成纤维细胞损伤加重牙周炎的关键机制
IF 11.8 1区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-07 DOI: 10.1016/j.envint.2026.110139
Yi He, Lejia Zhang, Shilin Jia, Leyi Liu, Fangyang Shi, Chen Yi, Yiming Li, Guanhui Chen, Wei Zhao, Dongsheng Yu
{"title":"Multi-omics reveals ferroptosis as a key mechanism in PM2.5-exacerbated periodontitis via gingival fibroblast damage","authors":"Yi He, Lejia Zhang, Shilin Jia, Leyi Liu, Fangyang Shi, Chen Yi, Yiming Li, Guanhui Chen, Wei Zhao, Dongsheng Yu","doi":"10.1016/j.envint.2026.110139","DOIUrl":"https://doi.org/10.1016/j.envint.2026.110139","url":null,"abstract":"","PeriodicalId":308,"journal":{"name":"Environment International","volume":"65 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146135425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Copper and zinc thresholds in EU topsoils: Insights from LUCAS and literature datasets 欧盟表层土壤中的铜和锌阈值:来自LUCAS和文献数据集的见解
IF 11.8 1区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-07 DOI: 10.1016/j.envint.2026.110133
Mina Kiani, Elise Van Eynde, Jakob Santner, Dietmar Horn, Panos Panagos, Alicia Hernandez-Mora, Olivier Duboc, Herbert Eigner, Gereon Heller, Stefan Geyer, Arwyn Jones, Kari Ylivainio
{"title":"Copper and zinc thresholds in EU topsoils: Insights from LUCAS and literature datasets","authors":"Mina Kiani, Elise Van Eynde, Jakob Santner, Dietmar Horn, Panos Panagos, Alicia Hernandez-Mora, Olivier Duboc, Herbert Eigner, Gereon Heller, Stefan Geyer, Arwyn Jones, Kari Ylivainio","doi":"10.1016/j.envint.2026.110133","DOIUrl":"https://doi.org/10.1016/j.envint.2026.110133","url":null,"abstract":"","PeriodicalId":308,"journal":{"name":"Environment International","volume":"5 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146138907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A hybrid approach for assessing source-oriented health risk and evaluating mitigation measures of potential toxic elements in road dust from mining areas 评估面向源的健康风险和评估矿区道路粉尘中潜在有毒元素缓解措施的混合方法
IF 11.8 1区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-07 DOI: 10.1016/j.envint.2026.110141
Shuhan Tian, Samantha C. Ying, Tao Liang, Zihao Han, Haonan Li, Xiaoya Ji, Yanting Li, Yuxin Zheng, Jinglong Tang
{"title":"A hybrid approach for assessing source-oriented health risk and evaluating mitigation measures of potential toxic elements in road dust from mining areas","authors":"Shuhan Tian, Samantha C. Ying, Tao Liang, Zihao Han, Haonan Li, Xiaoya Ji, Yanting Li, Yuxin Zheng, Jinglong Tang","doi":"10.1016/j.envint.2026.110141","DOIUrl":"https://doi.org/10.1016/j.envint.2026.110141","url":null,"abstract":"","PeriodicalId":308,"journal":{"name":"Environment International","volume":"1 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146138931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mortality, morbidity and healthcare costs of short-term high temperatures and heatwaves exposure in older populations: a global systematic review and meta-analysis 老年人短期高温和热浪暴露的死亡率、发病率和医疗成本:一项全球系统综述和荟萃分析
IF 11.8 1区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-06 DOI: 10.1016/j.envint.2026.110129
Sabrina Günsche, Matthew A. Borg, Olga Anikeeva, Blesson M. Varghese, Yannan Li, Dinesh Bhandari, Jing Li, Haoran Yang, Yihan Shi, Jingwen Liu, Keith Dear, Bertram Ostendorf, Nigel Stocks, Danny Liew, Peng Bi
{"title":"Mortality, morbidity and healthcare costs of short-term high temperatures and heatwaves exposure in older populations: a global systematic review and meta-analysis","authors":"Sabrina Günsche, Matthew A. Borg, Olga Anikeeva, Blesson M. Varghese, Yannan Li, Dinesh Bhandari, Jing Li, Haoran Yang, Yihan Shi, Jingwen Liu, Keith Dear, Bertram Ostendorf, Nigel Stocks, Danny Liew, Peng Bi","doi":"10.1016/j.envint.2026.110129","DOIUrl":"https://doi.org/10.1016/j.envint.2026.110129","url":null,"abstract":"","PeriodicalId":308,"journal":{"name":"Environment International","volume":"59 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146134219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prenatal exposure to wildfire-related PM2.5 and autism spectrum disorder in children born in California between 2001–2019 2001年至2019年期间在加州出生的儿童产前暴露于野火相关的PM2.5和自闭症谱系障碍
IF 11.8 1区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-06 DOI: 10.1016/j.envint.2026.110131
Karl O’Sharkey, Sanjali Mitra, Ting Chow, Amanda Goodrich, Kathryn Conlon, Miriam Nuño, Deborah H. Bennett, Sean Raffuse, Mohammad Astaneh, Yusheng Zhao, Michael Kleeman, Beate Ritz, Rebecca J. Schmidt

Background

Wildfire smoke is an increasingly prevalent source of air pollution and contains a complex mixture of neurotoxic constituents that could affect neurodevelopment, yet its potential role in autism spectrum disorder (ASD) etiology remains unexplored. We examined associations between wildfire-specific PM2.5 exposures and ASD risk in California births, considering exposure timing, intensity, and background air pollution.

Methods

We analyzed 8.6 million births in California from 2001 to 2019, linking records to ASD diagnoses in California Department of Developmental Services records through 2022. Wildfire-related PM2.5 exposures, including biomass burning and wildland-urban-interface (WUI) source tracers, were estimated for preconception, pregnancy, and post-pregnancy periods. Exposure metrics included continuous, percentile-based, and episode-based indicators. Logistic regression was used to estimate odds ratios, adjusting for sociodemographic covariates. Stratified analyses were conducted by background PM2.5, urbanicity, diagnostic era, and sex.

Results

Continuous wildfire-specific exposures during the pregnancy-period were weakly associated with ASD, but stronger effects emerged at high exposure percentiles and during intense wildfire episodes (≥35 µg/m3). Associations were most pronounced among children in the lowest quartile of prenatal background PM2.5, with odds of ASD increasing by 50% for those in the > 90th percentile of wildfire PM2.5 during pregnancy. WUI-related PM2.5 was associated with ASD in metro areas, suggesting unique toxicity. Effects were stronger in non-metro regions, with the exception of WUI-related PM2.5, for births occurring after the implementation of DSM-5, and in White children. Sex differences were minimal, but showed stronger effect estimates for WUI-related PM2.5 and high exposure episodes for males.

Conclusion

Wildfire smoke exposure during pregnancy may increase ASD risk, particularly in low background air pollution and rural settings. High-intensity wildfire events were most strongly associated with ASD, underscoring the need for targeted policies, such as vegetation management, land use planning, and indoor filtration upgrades in the context of increasing wildfire frequency and severity.
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引用次数: 0
Engineered probiotics for the in vivo mitigation of waterborne uranium toxicity and bioaccumulation 工程益生菌在体内减轻水中铀的毒性和生物积累
IF 11.8 1区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-06 DOI: 10.1016/j.envint.2026.110127
Haidong Li, Feifei Zhang, Chenya Wang, Zhencun Cui, Yina Liu, Zhenhua Song, Lingyan Yuan, Xiaolei Chen, Yumin Wu, Wangsuo Wu, Longlong Tian
Uranium (U) contamination of water sources, arising from anthropogenic activities such as mining and nuclear fallout, poses a significant global threat to water quality and public health. Ingestion of U-contaminated water and food results in bioaccumulation, primarily within the kidneys and bones, leading to severe nephrotoxicity and potential long-term health consequences. Addressing this challenge, we present a novel bio-intervention strategy leveraging a genetically engineered probiotic for the prevention of U absorption at its primary entry point—the gastrointestinal tract. We engineered Escherichia coli Nissle 1917 (EcN) to express a high-affinity uranyl-binding protein (U09), generating the EcN-U strain. EcN-U sequestered soluble uranyl ions (UO22+) within the gut lumen via selective and efficient binding, leading to fecal excretion and prevention of systemic absorption. In a murine model of acute UO22+ exposure, EcN-U pre-treatment significantly enhanced survival rates. Furthermore, in chronic exposure models utilizing mice, rats, and beagle dogs, EcN-U pre-treatment demonstrably reduced U accumulation in target organs by approximately 80%. Concurrently, this intervention alleviated oxidative stress biomarkers, restored gut microbiota homeostasis, and mitigated intestinal histopathological damage. Our findings establish engineered probiotics as a pragmatic and potent strategy for environmental health protection, offering a proactive and viable solution for public health risk mitigation associated with waterborne uranium contamination.
{"title":"Engineered probiotics for the in vivo mitigation of waterborne uranium toxicity and bioaccumulation","authors":"Haidong Li, Feifei Zhang, Chenya Wang, Zhencun Cui, Yina Liu, Zhenhua Song, Lingyan Yuan, Xiaolei Chen, Yumin Wu, Wangsuo Wu, Longlong Tian","doi":"10.1016/j.envint.2026.110127","DOIUrl":"https://doi.org/10.1016/j.envint.2026.110127","url":null,"abstract":"Uranium (U) contamination of water sources, arising from anthropogenic activities such as mining and nuclear fallout, poses a significant global threat to water quality and public health. Ingestion of U-contaminated water and food results in bioaccumulation, primarily within the kidneys and bones, leading to severe nephrotoxicity and potential long-term health consequences. Addressing this challenge, we present a novel bio-intervention strategy leveraging a genetically engineered probiotic for the prevention of U absorption at its primary entry point—the gastrointestinal tract. We engineered<!-- --> <em>Escherichia coli</em> <em>Nissle</em> 1917 (EcN) to express a high-affinity uranyl-binding protein (U09), generating the EcN-U strain. EcN-U sequestered soluble uranyl ions (UO<sub>2</sub><sup>2+</sup>) within the gut lumen via selective and efficient binding, leading to fecal excretion and prevention of systemic absorption. In a murine model of acute<!-- --> <!-- -->UO<sub>2</sub><sup>2+</sup> exposure, EcN-U pre-treatment significantly enhanced survival rates. Furthermore, in chronic exposure models utilizing mice, rats, and beagle dogs, EcN-U pre-treatment demonstrably reduced U accumulation in target organs by approximately 80%. Concurrently, this intervention alleviated oxidative stress biomarkers, restored gut microbiota homeostasis, and mitigated intestinal histopathological damage. Our findings establish engineered probiotics as a pragmatic and potent strategy for environmental health protection, offering a proactive and viable solution for public health risk mitigation associated with waterborne uranium contamination.","PeriodicalId":308,"journal":{"name":"Environment International","volume":"39 1","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146129657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Environment International
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