Amplitude coupling is altered in delirium of various etiologies: Results from a retrospective multi-center case-control EEG study

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY Clinical Neurophysiology Pub Date : 2025-03-11 DOI:10.1016/j.clinph.2025.02.266

Robert Fleischmann , Annerose Mengel , Cornelis J. Stam , Sophie Leroy , Pauline Schneider , Arjen J.C. Slooter , Johannes Ehler , Edwin van Dellen

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Abstract

Objective

Delirium manifests with comparable clinical presentations, regardless of its heterogeneous etiology. This suggests a final common pathway such as decreased electroencephalography (EEG) phase coupling. This study investigates if amplitude coupling, another mode of neural communication, is altered in delirium due to different etiologies.

Methods

We analyzed EEGs of patients from three sites with either postoperative, poststroke or medical delirium and non-delirious control patients. Amplitude envelope correlation corrected for spatial leakage (AECc) was calculated and Mann-Whitney U-tests were used to compare patients with or without delirium. AECc differences among delirium types were compared using Kruskal-Wallis tests.

Results

AECc was significantly increased in delirious (n = 173, age 79.2±9.3 years, 46 % female) as compared to non-delirious (n = 204, age 72.9±13.1 years, 45 % female) patients in the delta (median, effect size of difference: 0.16 vs. 0.12, r = 0.28, p < 0.01) and beta band (0.11 vs. 0.09, r = 0.14, p = 0.04). These changes did not differ among delirium types (p > 0.05).

Conclusions

We found modestly higher delta and beta band AECc in delirium compared to non-delirious control patients, regardless of the presumed etiology.

Significance

This study provides evidence for altered amplitude coupling as mode of impaired neuronal communication in delirium, the role of which should be investigated in future studies of neural network pathophysiology.

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振幅耦合在不同病因的谵妄中改变：来自回顾性多中心病例对照脑电图研究的结果

目的：谵妄的临床表现具有可比性，而不考虑其异质性病因。这表明最后的共同途径，如减少脑电图（EEG）相耦合。本研究探讨振幅耦合，另一种神经通讯模式，是否在谵妄中由于不同的病因而改变。方法分析脑卒中术后、脑卒中后或药物性谵妄患者和非谵妄对照患者三个部位的脑电图。计算经空间渗漏校正的振幅包络相关（AECc），并使用Mann-Whitney u检验比较谵妄患者和非谵妄患者。采用Kruskal-Wallis试验比较谵妄类型间的AECc差异。结果谵妄患者（n = 173人，年龄79.2±9.3岁，女性46%）的saecc显著高于非谵妄患者（n = 204人，年龄72.9±13.1岁，女性45%）(中位数，效应值差异：0.16 vs. 0.12, r = 0.28, p <；0.01)和β频带(0.11 vs 0.09, r = 0.14, p = 0.04)。这些变化在谵妄类型之间没有差异(p >；0.05)。结论：与非谵妄对照患者相比，我们发现谵妄患者的δ和β带AECc略高，无论推测的病因如何。意义本研究为谵妄时振幅耦合改变是神经元通讯受损的一种模式提供了证据，其作用有待于在未来神经网络病理生理学研究中进一步探讨。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.