Eleanor P. Bentley , Oriole W. Song , Ira Glassman , Leepakshi Johar , Cheldon A. Alcantara , Veronica L. Show , Adam R. Johnson , Hendrik Szurmant , David A. Vosburg
{"title":"One-pot synthesis and biological evaluation of N-fused imidazoles as antibacterial agents and bacterial topoisomerase inhibitors","authors":"Eleanor P. Bentley , Oriole W. Song , Ira Glassman , Leepakshi Johar , Cheldon A. Alcantara , Veronica L. Show , Adam R. Johnson , Hendrik Szurmant , David A. Vosburg","doi":"10.1016/j.rechem.2025.102191","DOIUrl":null,"url":null,"abstract":"<div><div>A series of <em>N</em>-fused imidazoles related to known inhibitors of human topoisomerase IIα were rapidly synthesized by a multicomponent GBB reaction under environmentally friendly conditions with microwave heating. Two of the compounds synthesized exhibited bacteriostatic activity against methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) and other gram-positive bacteria, but none showed significant inhibition of bacterial topoisomerase.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"15 ","pages":"Article 102191"},"PeriodicalIF":4.2000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Results in Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2211715625001742","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/13 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
A series of N-fused imidazoles related to known inhibitors of human topoisomerase IIα were rapidly synthesized by a multicomponent GBB reaction under environmentally friendly conditions with microwave heating. Two of the compounds synthesized exhibited bacteriostatic activity against methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive bacteria, but none showed significant inhibition of bacterial topoisomerase.
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