Results in Chemistry最新文献

Anti-corrosive efficiency of salvadora persica plant stick powder on SS 316L orthodontic wire in artificial saliva 人工唾液中沙瓦多巴植物棒粉对 SS 316L 正畸钢丝的抗腐蚀效率

IF 2.5 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry

Pub Date : 2024-11-13 DOI: 10.1016/j.rechem.2024.101894

H.Mohamed Kasim Sheit , K.S. Mohan , P. Srinivasan , S.Esakki Muthu , A. Dinesh , B. Rajeswari , L. Srimathi Priya , Lalitha Gnanasekaran , Munawar Iqbal

The efficacy of stainless steel 316L (SS 316L) orthodontic wire in mitigating corrosion within artificial saliva was scrutinized both in the presence and absence of Salvadora persica (SP) stick powder, employing electrochemical methodologies. Potentiodynamic polarization assessments demonstrated a notable cathodic shift in the corrosion potential of SS 316L upon the introduction of SP extract, which signifies a reduction in anodic dissolution rates. A marked enhancement in linear polarization resistance was recorded, corresponding to a diminished corrosion current density, thereby evidencing substantial corrosion mitigation. Data obtained from electrochemical impedance spectroscopy corroborated these observations, revealing an augmentation in impedance and charge transfer resistance alongside a reduction in double-layer capacitance, indicative of suppressed charge transfer at the SS 316L/electrolyte interface. Open-circuit potential (OCP) metrics demonstrated that the system incorporating SP presented more negative values relative to the control, reinforcing the inhibitory effect exerted by the constituents of SP. UV–Visible and FTIR spectral analyses substantiated the existence of bioactive compounds within SP powder, with minor shifts in spectral bands noted on the SS 316L surface subsequent to immersion, suggesting adsorption of SP constituents. Scanning electron microscopy (SEM) and atomic force microscopy (AFM) imaging of SS 316L specimens exposed to SP-enhanced artificial saliva exhibited diminished surface degradation in comparison to the control samples. These findings imply that constituents of SP, characterized by polar functional groups (e.g., O, N, and S), engage with SS 316L ions, thereby facilitating the formation of a protective layer and augmenting corrosion resistance. This investigation underscores the prospective application of Salvadora persica in prolonging the durability of SS 316L orthodontic devices utilized within an oral milieu.

通过电化学方法，研究了在有和没有萨尔瓦多柿（Salvadora persica，SP）棒粉的情况下，不锈钢 316L （SS 316L）正畸钢丝在减轻人工唾液腐蚀方面的功效。电位极化评估结果表明，引入 SP 提取物后，SS 316L 的腐蚀电位发生了明显的阴极转变，这表明阳极溶解速率降低了。记录到的线性极化电阻明显增强，与腐蚀电流密度的降低相对应，从而证明了腐蚀的实质性缓解。电化学阻抗光谱法获得的数据证实了这些观察结果，显示阻抗和电荷转移电阻增加，同时双层电容降低，表明 SS 316L/电解质界面的电荷转移受到抑制。开路电位（OCP）指标表明，与对照组相比，含有 SP 的系统呈现出更多的负值，从而加强了 SP 成分的抑制作用。紫外可见光谱和傅立叶变换红外光谱分析证实了 SP 粉末中存在生物活性化合物，浸泡后 SS 316L 表面的光谱带发生了细微变化，表明 SP 成分被吸附。扫描电子显微镜（SEM）和原子力显微镜（AFM）成像显示，与对照样品相比，暴露在经 SP 增强的人工唾液中的 SS 316L 试样的表面降解程度降低。这些发现表明，以极性官能团（如 O、N 和 S）为特征的 SP 成分与 SS 316L 离子接触，从而促进了保护层的形成并增强了耐腐蚀性。这项研究强调了Salvadora persica在延长口腔环境中使用的 SS 316L 正畸装置的耐用性方面的应用前景。

{"title":"Anti-corrosive efficiency of salvadora persica plant stick powder on SS 316L orthodontic wire in artificial saliva","authors":"H.Mohamed Kasim Sheit , K.S. Mohan , P. Srinivasan , S.Esakki Muthu , A. Dinesh , B. Rajeswari , L. Srimathi Priya , Lalitha Gnanasekaran , Munawar Iqbal","doi":"10.1016/j.rechem.2024.101894","DOIUrl":"10.1016/j.rechem.2024.101894","url":null,"abstract":"<div><div>The efficacy of stainless steel 316L (SS 316L) orthodontic wire in mitigating corrosion within artificial saliva was scrutinized both in the presence and absence of Salvadora persica (SP) stick powder, employing electrochemical methodologies. Potentiodynamic polarization assessments demonstrated a notable cathodic shift in the corrosion potential of SS 316L upon the introduction of SP extract, which signifies a reduction in anodic dissolution rates. A marked enhancement in linear polarization resistance was recorded, corresponding to a diminished corrosion current density, thereby evidencing substantial corrosion mitigation. Data obtained from electrochemical impedance spectroscopy corroborated these observations, revealing an augmentation in impedance and charge transfer resistance alongside a reduction in double-layer capacitance, indicative of suppressed charge transfer at the SS 316L/electrolyte interface. Open-circuit potential (OCP) metrics demonstrated that the system incorporating SP presented more negative values relative to the control, reinforcing the inhibitory effect exerted by the constituents of SP. UV–Visible and FTIR spectral analyses substantiated the existence of bioactive compounds within SP powder, with minor shifts in spectral bands noted on the SS 316L surface subsequent to immersion, suggesting adsorption of SP constituents. Scanning electron microscopy (SEM) and atomic force microscopy (AFM) imaging of SS 316L specimens exposed to SP-enhanced artificial saliva exhibited diminished surface degradation in comparison to the control samples. These findings imply that constituents of SP, characterized by polar functional groups (e.g., O, N, and S), engage with SS 316L ions, thereby facilitating the formation of a protective layer and augmenting corrosion resistance. This investigation underscores the prospective application of Salvadora persica in prolonging the durability of SS 316L orthodontic devices utilized within an oral milieu.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"12 ","pages":"Article 101894"},"PeriodicalIF":2.5,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142661152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of prodelphinidin B2 3,3′′-digallate using AgOTf-mediated self-condensation 利用 AgOTf 介导的自缩合合成前花翠素 B2 3,3′′-digallate

IF 2.5 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry

Pub Date : 2024-11-13 DOI: 10.1016/j.rechem.2024.101902

Hana Saito , Yoriko Takahashi , Atsushi Kawamura , Hidefumi Makabe

The Lewis acid mediated self-condensation of an epigallocatechin gallate derivative was examined. We found that AgOTf as a Lewis acid and diethylene glycol as a leaving group at C-4 position afforded a dimeric epigallocatechin gallate derivative in a moderate yield. The condensed product was applied to the synthesis of prodelphinidin B2 3,3′′-digallate.

我们研究了路易斯酸介导的表没食子儿茶素没食子酸酯衍生物的自缩合。我们发现，以 AgOTf 为路易斯酸，二甘醇为 C-4 位上的离去基团，可以得到二聚表没食子儿茶素没食子酸酯衍生物，收率适中。该缩合产物被用于合成前花翠素 B2 3,3′′-二没食子酸酯。

引用次数: 0

Synthesis, crystal structure, cytotoxicity (MCF-7 and HeLa) and free radical scavenging activity of the hydrazones derived from 2-methylsulfonyl-5-nitrobenzaldehyde 由 2-甲磺酰基-5-硝基苯甲醛衍生的肼类化合物的合成、晶体结构、细胞毒性（MCF-7 和 HeLa）和自由基清除活性

IF 2.5 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry

Pub Date : 2024-11-13 DOI: 10.1016/j.rechem.2024.101896

Marole M. Maluleka , Malose J. Mphahlele

The rising levels of breast and cervical cancers among women have become public health problem with high economic burden globally and more especially in low- and middle-income countries. This necessitates discoving new and potent anticancer drugs with reduced or no side effects. The hydrazones derived from 2-formyl-4-nitrophenyl methanesulfonate were characterized using a combination of spectroscopic and single-crystal X-ray diffraction (XRD) techniques. The compounds were, in turn, evaluated for antigrowth effect in vitro against the human breast adenocarcinoma (MCF-7) and human cervical cancer (HeLa) cell lines and for cytotoxicity against the African Green Monkey kidney (Vero) cell line. The presence of a chlorine atom on the para position of the phenylhydrazone moiety of 3b resulted in increased cytotoxicity against the MCF-7 and the HeLa cell lines compared to camptothecin (IC₅₀ = 9.15 ± 0.84 µM and 3.71 ± 0.16 µM, respectively) with IC₅₀ values of 5.64 ± 0.84 µM and 2.40 ± 0.13 µM, respectively. Compounds 2, 3a and 3b were found to exhibit significantly reduced toxicity against the Vero cells compared to the anti-cancer drugs, doxorubicin (IC₅₀ = 0.78 ± 0.04 µM) and nintedanib (IC₅₀ = 0.24 ± 0.02 µM) with the IC₅₀ values of 17.86 ± 1.12, 11.89 ± 1.01 and 24.42 ± 0.70 µM, respectively. The hydrazones 3a and 3b exhibited a strong inhibitory effect against the vascular endothelial growth factor receptor-2 (VEGFR-2) tyrosine kinase (IC₅₀ = 5.78 ± 0.039 μM and 5.79 ± 0.053 µM, respectively) compared to the carbaldehyde precursor 2 (IC₅₀ = 8.01 ± 0.052 µM) though less active compared to nintedanib (IC₅₀ = 1.05 ± 0.193 µM). The hydrazone derivatives exhibited significant 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity compared to ascorbic acid and the parent 2-formyl-4-nitrophenylmethanesulfonate. In silico molecular docking studies revealed the binding potential of the hydrazones at the active site of VEGFR-2 tyrosine kinase and cytochrome c peroxidase.

妇女乳腺癌和宫颈癌发病率的上升已成为公共卫生问题，给全球，尤其是中低收入国家造成了沉重的经济负担。这就需要寻找新的、有效的、副作用小或无副作用的抗癌药物。研究人员采用光谱和单晶 X 射线衍射 (XRD) 技术，对从 2-甲酰基-4-硝基苯甲磺酸盐中提取的酰肼进行了表征。然后，在体外评估了这些化合物对人类乳腺腺癌（MCF-7）和人类宫颈癌（HeLa）细胞系的抗生长作用，以及对非洲绿猴肾（Vero）细胞系的细胞毒性。与喜树碱（IC50 = 9.15 ± 0.84 µM 和 3.71 ± 0.16 µM）相比，3b 的苯腙分子对位上存在一个氯原子，导致其对 MCF-7 和 HeLa 细胞系的细胞毒性增加，IC50 值分别为 5.64 ± 0.84 µM 和 2.40 ± 0.13 µM。与抗癌药物多柔比星（IC50 = 0.78 ± 0.04 µM）和宁替达尼（IC50 = 0.24 ± 0.02 µM）相比，化合物 2、3a 和 3b 对 Vero 细胞的毒性明显降低，IC50 值分别为 17.86 ± 1.12 µM、11.89 ± 1.01 µM 和 24.42 ± 0.70 µM。与甲醛前体 2（IC50 = 8.01 ± 0.052 µM）相比，酰腙 3a 和 3b 对血管内皮生长因子受体-2（VEGFR-2）酪氨酸激酶具有很强的抑制作用（IC50 = 5.78 ± 0.039 µM和 5.79 ± 0.053 µM），但与宁替达尼（IC50 = 1.05 ± 0.193 µM）相比，活性较低。与抗坏血酸和母体 2-甲酰基-4-硝基苯甲磺酸盐相比，腙衍生物具有显著的 2,2-二苯基-1-苦基肼（DPPH）自由基清除活性。硅学分子对接研究揭示了这些酰肼在血管内皮生长因子受体-2 酪氨酸激酶和细胞色素 c 过氧化物酶活性位点的结合潜力。

{"title":"Synthesis, crystal structure, cytotoxicity (MCF-7 and HeLa) and free radical scavenging activity of the hydrazones derived from 2-methylsulfonyl-5-nitrobenzaldehyde","authors":"Marole M. Maluleka , Malose J. Mphahlele","doi":"10.1016/j.rechem.2024.101896","DOIUrl":"10.1016/j.rechem.2024.101896","url":null,"abstract":"<div><div>The rising levels of breast and cervical cancers among women have become public health problem with high economic burden globally and more especially in low- and middle-income countries. This necessitates discoving new and potent anticancer drugs with reduced or no side effects. The hydrazones derived from 2-formyl-4-nitrophenyl methanesulfonate were characterized using a combination of spectroscopic and single-crystal X-ray diffraction (XRD) techniques. The compounds were, in turn, evaluated for antigrowth effect in vitro against the human breast adenocarcinoma (MCF-7) and human cervical cancer (HeLa) cell lines and for cytotoxicity against the African Green Monkey kidney (Vero) cell line. The presence of a chlorine atom on the para position of the phenylhydrazone moiety of 3b resulted in increased cytotoxicity against the MCF-7 and the HeLa cell lines compared to camptothecin (IC50 = 9.15 ± 0.84 µM and 3.71 ± 0.16 µM, respectively) with IC50 values of 5.64 ± 0.84 µM and 2.40 ± 0.13 µM, respectively. Compounds 2, 3a and 3b were found to exhibit significantly reduced toxicity against the Vero cells compared to the anti-cancer drugs, doxorubicin (IC50 = 0.78 ± 0.04 µM) and nintedanib (IC50 = 0.24 ± 0.02 µM) with the IC50 values of 17.86 ± 1.12, 11.89 ± 1.01 and 24.42 ± 0.70 µM, respectively. The hydrazones 3a and 3b exhibited a strong inhibitory effect against the vascular endothelial growth factor receptor-2 (VEGFR-2) tyrosine kinase (IC50 = 5.78 ± 0.039 μM and 5.79 ± 0.053 µM, respectively) compared to the carbaldehyde precursor 2 (IC50 = 8.01 ± 0.052 µM) though less active compared to nintedanib (IC50 = 1.05 ± 0.193 µM). The hydrazone derivatives exhibited significant 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity compared to ascorbic acid and the parent 2-formyl-4-nitrophenylmethanesulfonate. In silico molecular docking studies revealed the binding potential of the hydrazones at the active site of VEGFR-2 tyrosine kinase and cytochrome c peroxidase.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"12 ","pages":"Article 101896"},"PeriodicalIF":2.5,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142661151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of research fields involving wastewater-based epidemiology and interdisciplinary spillovers using a structural topic model 利用结构性主题模型分析涉及基于废水的流行病学和跨学科溢出效应的研究领域

IF 2.5 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry

Pub Date : 2024-11-10 DOI: 10.1016/j.rechem.2024.101897

Michio Murakami , Yoshitaka Nishikawa , Masaaki Kitajima

To further the academic development and practical application of wastewater-based epidemiology (WBE), a greater understanding of its impact across various research fields, academic disciplines, and interdisciplinary spillovers is required. However, no previous studies have applied the structural topic model to WBE papers to characterize different topics or to study the interdisciplinary spillover effects between topics. Therefore, we used a structural topic model to provide an overview of the topics involved in WBE in various research fields and elucidate their characteristics. The topics in the literature cited by high-impact papers and the literature citing high-impact papers were also analyzed to identify spillovers in WBE research between fields. A total of 2842 papers were extracted using Scopus on July 3, 2023, and classified into 5 topics related to WBE using the structural topic model, with the manual exclusion of topics highly relevant to non-WBE papers. WBE topics included “illicit drugs,” “SARS-CoV-2 detection,” “virus and genotype,” “public health and COVID-19,” and “COVID-19 and clinic.” The average publication years for “virus and genotype” and “illicit drugs” were 2017 and 2019, which were earlier than those of COVID-19-related papers (2020–2022). Furthermore, “virus and genotype” had fewer papers (N = 241) and citations (arithmetic mean, 21.8), whereas “illicit drugs” had a higher number of papers (N = 475) and citations (32.3). Although research on COVID-19 has only recently begun, “SARS-CoV-2 detection” had a higher number of papers (N = 348) and citations (32.8). Analysis of the sources and effects of high-impact papers on each topic showed that public health-driven studies referred to numerous illicit drugs and created connections with subsequent COVID-19-related papers. Studies that link existing research fields with future risk factors for major public health crises indicate the direction for innovative interdisciplinary research.

为了促进基于废水的流行病学（WBE）的学术发展和实际应用，需要进一步了解其在不同研究领域、学科之间的影响以及跨学科溢出效应。然而，之前没有研究将结构性主题模型应用于 WBE 论文，以描述不同主题的特征或研究主题之间的跨学科溢出效应。因此，我们采用了结构性主题模型来概述各研究领域的世界经济伦理所涉及的主题，并阐明其特点。此外，我们还分析了高影响力论文所引用文献中的主题以及高影响力论文所引用文献中的主题，以确定WBE研究在不同领域之间的溢出效应。2023 年 7 月 3 日，使用 Scopus 共提取了 2842 篇论文，并使用结构化主题模型将其分为 5 个与 WBE 相关的主题，人工排除了与非 WBE 论文高度相关的主题。WBE主题包括 "非法药物"、"SARS-CoV-2检测"、"病毒与基因型"、"公共卫生与COVID-19 "和 "COVID-19与临床"。病毒与基因型 "和 "非法药物 "的平均发表年份为 2017 年和 2019 年，早于 COVID-19 相关论文的发表年份（2020-2022 年）。此外，"病毒和基因型 "的论文数量（N = 241）和引用次数（算术平均数，21.8）较少，而 "违禁药物 "的论文数量（N = 475）和引用次数（32.3）较多。虽然对 COVID-19 的研究最近才开始，但 "SARS-CoV-2 检测 "的论文数（N = 348）和引用次数（32.8）都较高。对每个主题的高影响力论文的来源和影响的分析表明，公共卫生驱动的研究提到了许多非法药物，并与随后的 COVID-19 相关论文建立了联系。将现有研究领域与重大公共卫生危机的未来风险因素联系起来的研究指明了创新性跨学科研究的方向。

{"title":"Analysis of research fields involving wastewater-based epidemiology and interdisciplinary spillovers using a structural topic model","authors":"Michio Murakami , Yoshitaka Nishikawa , Masaaki Kitajima","doi":"10.1016/j.rechem.2024.101897","DOIUrl":"10.1016/j.rechem.2024.101897","url":null,"abstract":"<div><div>To further the academic development and practical application of wastewater-based epidemiology (WBE), a greater understanding of its impact across various research fields, academic disciplines, and interdisciplinary spillovers is required. However, no previous studies have applied the structural topic model to WBE papers to characterize different topics or to study the interdisciplinary spillover effects between topics. Therefore, we used a structural topic model to provide an overview of the topics involved in WBE in various research fields and elucidate their characteristics. The topics in the literature cited by high-impact papers and the literature citing high-impact papers were also analyzed to identify spillovers in WBE research between fields. A total of 2842 papers were extracted using Scopus on July 3, 2023, and classified into 5 topics related to WBE using the structural topic model, with the manual exclusion of topics highly relevant to non-WBE papers. WBE topics included “illicit drugs,” “SARS-CoV-2 detection,” “virus and genotype,” “public health and COVID-19,” and “COVID-19 and clinic.” The average publication years for “virus and genotype” and “illicit drugs” were 2017 and 2019, which were earlier than those of COVID-19-related papers (2020–2022). Furthermore, “virus and genotype” had fewer papers (N = 241) and citations (arithmetic mean, 21.8), whereas “illicit drugs” had a higher number of papers (N = 475) and citations (32.3). Although research on COVID-19 has only recently begun, “SARS-CoV-2 detection” had a higher number of papers (N = 348) and citations (32.8). Analysis of the sources and effects of high-impact papers on each topic showed that public health-driven studies referred to numerous illicit drugs and created connections with subsequent COVID-19-related papers. Studies that link existing research fields with future risk factors for major public health crises indicate the direction for innovative interdisciplinary research.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"12 ","pages":"Article 101897"},"PeriodicalIF":2.5,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142661149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PD-1 agonist: A novel therapeutic approach to resolve atherosclerosis PD-1 激动剂：解决动脉粥样硬化的新型治疗方法

IF 2.5 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry

Pub Date : 2024-11-09 DOI: 10.1016/j.rechem.2024.101892

Jiahui Chen , Wanqian Yu , Le Liao , Linghua Fu , Pingping Yang

Atherosclerosis, which is the primary cause of several leading fatal diseases worldwide, has long been a challenge, and thus the need for effective treatments is urgent. The discovery of the immune checkpoint proteins programmed cell death protein 1 (PD-1) and programmed death ligand 1 (PD-L1), which are negative regulators that inhibit immune responses, has led to the development of immunotherapeutic strategies for the management of atherosclerosis. Atherosclerosis mainly occurs as an adaptive immune response that results in an increased ratio of M1/M2 macrophages, and PD-1 can suppress this increased ratio through T-cell-mediated and macrophage-mediated pathways, thus controlling the course of atherosclerotic inflammation. Currently, 6 confirmed PD-1 agonists have been shown to inhibit inflammatory processes, which indicates the potential of PD-1 agonists as drugs for the treatment of atherosclerosis and other inflammatory diseases. PD-1 agonists have demonstrated their anti-inflammatory effects in both preclinical studies and clinical trials. These drugs also show considerable clinical potential when used in combination with aspirin and statins. In the future, PD-1 agonists are expected to become a novel treatment for atherosclerosis and other inflammatory diseases.

动脉粥样硬化是导致全球多种主要致命疾病的主要原因，长期以来一直是一个难题，因此迫切需要有效的治疗方法。免疫检查点蛋白程序性细胞死亡蛋白 1（PD-1）和程序性死亡配体 1（PD-L1）是抑制免疫反应的负调控因子，它们的发现促进了治疗动脉粥样硬化的免疫治疗策略的发展。动脉粥样硬化的发生主要是一种适应性免疫反应，导致 M1/M2 巨噬细胞比例增加，而 PD-1 可以通过 T 细胞介导和巨噬细胞介导的途径抑制这种比例的增加，从而控制动脉粥样硬化炎症的进程。目前，已证实有 6 种 PD-1 激动剂可抑制炎症过程，这表明 PD-1 激动剂有可能成为治疗动脉粥样硬化和其他炎症性疾病的药物。PD-1 激动剂已在临床前研究和临床试验中证明了其抗炎作用。当这些药物与阿司匹林和他汀类药物联合使用时，也显示出了相当大的临床潜力。未来，PD-1 激动剂有望成为治疗动脉粥样硬化和其他炎症性疾病的新型疗法。

{"title":"PD-1 agonist: A novel therapeutic approach to resolve atherosclerosis","authors":"Jiahui Chen , Wanqian Yu , Le Liao , Linghua Fu , Pingping Yang","doi":"10.1016/j.rechem.2024.101892","DOIUrl":"10.1016/j.rechem.2024.101892","url":null,"abstract":"<div><div>Atherosclerosis, which is the primary cause of several leading fatal diseases worldwide, has long been a challenge, and thus the need for effective treatments is urgent. The discovery of the immune checkpoint proteins programmed cell death protein 1 (PD-1) and programmed death ligand 1 (PD-L1), which are negative regulators that inhibit immune responses, has led to the development of immunotherapeutic strategies for the management of atherosclerosis. Atherosclerosis mainly occurs as an adaptive immune response that results in an increased ratio of M1/M2 macrophages, and PD-1 can suppress this increased ratio through T-cell-mediated and macrophage-mediated pathways, thus controlling the course of atherosclerotic inflammation. Currently, 6 confirmed PD-1 agonists have been shown to inhibit inflammatory processes, which indicates the potential of PD-1 agonists as drugs for the treatment of atherosclerosis and other inflammatory diseases. PD-1 agonists have demonstrated their anti-inflammatory effects in both preclinical studies and clinical trials. These drugs also show considerable clinical potential when used in combination with aspirin and statins. In the future, PD-1 agonists are expected to become a novel treatment for atherosclerosis and other inflammatory diseases.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"12 ","pages":"Article 101892"},"PeriodicalIF":2.5,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142661094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structure activity relationships of antischistosomal N-phenylbenzamides by incorporation of electron-withdrawing functionalities 通过加入抽电子官能团实现抗血吸虫 N-苯基苯甲酰胺的结构活性关系

IF 2.5 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry

Pub Date : 2024-11-06 DOI: 10.1016/j.rechem.2024.101890

Ameera Mohammed Dawoodjee , John Sichinga , Harrison Banda , Steve Mbaya , Evelyn Funjika , Godfrey Mayoka , Christabel Hikaambo , Karol R. Francisco , Yujie Uli Sun , Lawrence J. Liu , Conor R. Caffrey , Peter Mubanga Cheuka

For the adult Schistosoma mansoni flatworm pathogen, we report further structure activity relationships (SAR) of 19 N-phenylbenzamide analogs. Our previous SAR studies, designed by selecting representative substituents from the Craig plot, identified 9 and 11 which possessed electron-withdrawing groups that benefited potency. This study sought to enhance the potency of this chemotype by incorporating other electron-withdrawing functionalities not studied previously and to overcome the potential pharmacokinetic liabilities associated with the high lipophilicity of frontrunner compounds. Compared to the most potent compound, 9 (EC₅₀ = 80 nM), from our previous work, the most potent compounds in the current study (32 (EC₅₀ = 1.17 µM), 34 (EC₅₀ = 1.64 µM) and 38 (EC₅₀ = 1.16 µM)) were less active although they retained single digit micromolar potency. Furthermore, compound 38 generated a CC₅₀ value of > 20 µM in counter toxicity screens using HEK 293 cells, translating to a wide selectivity index of > 17.

针对曼氏血吸虫扁形虫成虫病原体，我们进一步报告了 19 种 N-苯基苯甲酰胺类似物的结构活性关系 (SAR)。我们之前的 SAR 研究是从克雷格图谱中选择具有代表性的取代基进行设计的，结果发现 9 和 11 具有可提高药效的抽电子基团。本研究试图通过加入以前未研究过的其他抽电子官能团来提高这种化学类型的药效，并克服前导化合物的高亲脂性所带来的潜在药代动力学问题。与之前研究中最强的化合物 9（EC50 = 80 nM）相比，本次研究中最强的化合物（32（EC50 = 1.17 µM）、34（EC50 = 1.64 µM）和 38（EC50 = 1.16 µM））虽然保持了个位数微摩尔的效力，但活性较低。此外，在使用 HEK 293 细胞进行的反毒性筛选中，化合物 38 的 CC50 值为 20 µM，即广泛选择性指数为 17。

{"title":"Structure activity relationships of antischistosomal N-phenylbenzamides by incorporation of electron-withdrawing functionalities","authors":"Ameera Mohammed Dawoodjee , John Sichinga , Harrison Banda , Steve Mbaya , Evelyn Funjika , Godfrey Mayoka , Christabel Hikaambo , Karol R. Francisco , Yujie Uli Sun , Lawrence J. Liu , Conor R. Caffrey , Peter Mubanga Cheuka","doi":"10.1016/j.rechem.2024.101890","DOIUrl":"10.1016/j.rechem.2024.101890","url":null,"abstract":"<div><div>For the adult Schistosoma mansoni flatworm pathogen, we report further structure activity relationships (SAR) of 19 N-phenylbenzamide analogs. Our previous SAR studies, designed by selecting representative substituents from the Craig plot, identified 9 and 11 which possessed electron-withdrawing groups that benefited potency. This study sought to enhance the potency of this chemotype by incorporating other electron-withdrawing functionalities not studied previously and to overcome the potential pharmacokinetic liabilities associated with the high lipophilicity of frontrunner compounds. Compared to the most potent compound, 9 (EC50 = 80 nM), from our previous work, the most potent compounds in the current study (32 (EC50 = 1.17 µM), 34 (EC50 = 1.64 µM) and 38 (EC50 = 1.16 µM)) were less active although they retained single digit micromolar potency. Furthermore, compound 38 generated a CC50 value of > 20 µM in counter toxicity screens using HEK 293 cells, translating to a wide selectivity index of > 17.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"12 ","pages":"Article 101890"},"PeriodicalIF":2.5,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142661093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-nucleophilic base promoted synthesis of azo-linked oxazolone-pyrazole hybrids: Antimicrobial, antitubercular, anticancer evaluations and in-silico modeling insights 非亲核碱促进偶氮连接的噁唑酮-吡唑混合物的合成：抗菌、抗结核、抗癌评估和微观建模见解

IF 2.5 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry

Pub Date : 2024-11-06 DOI: 10.1016/j.rechem.2024.101887

Bonny Y. Patel , Vidhi Joshi , Sangeetha Subramanian , Gopal Italiya , Prasanna Srinivasan Ramalingam , Sivakumar Arumugam , Sanjay D. Hadiyal , Al-Anood Mohamed Al-Dies

Ten new non-nucleophilic base (DBU) catalyzed oxazolone-bearing pyrazole derivatives were created to treat infectious diseases caused by bacterial, mycobacterial strains, and cancerous cell lines. Compounds 7b and 7c showed excellent antibacterial and antifungal activity. Compound 7b was highly effective against M. tuberculosis H37Rv, with a MIC of 0.06 μg/mL and significant binding affinities to AcrB of E. coli (−12 Kcal/mol), TriABC of P. aeruginosa (−12.5 Kcal/mol), and MepR of S. aureus (−10.6 Kcal/mol). Based on the findings, compounds 7b, 7c, and 7e exhibit proficient binding affinity with two essential targets, namely Enoyl-[acyl-carrier-protein] reductase and Topoisomerase I, of M. tuberculosis. Compound 7b showed superior cytotoxic activity against all cancer types except leukemia with GI₅₀ values of 1.26–1.83 µM and LC₅₀ values of 5.36–7.88 µM. Compound 7a demonstrated remarkable anticancer activity against colon, melanoma, ovarian, renal, and breast cancer cell lines with GI₅₀ values of 1.60–2.55 µM.

十种新的非亲核碱（DBU）催化的含噁唑酮的吡唑衍生物被创造出来，用于治疗由细菌、分枝杆菌菌株和癌细胞株引起的感染性疾病。化合物 7b 和 7c 显示出卓越的抗菌和抗真菌活性。化合物 7b 对结核杆菌 H37Rv 非常有效，其 MIC 为 0.06 μg/mL，与大肠杆菌的 AcrB（-12 Kcal/mol）、绿脓杆菌的 TriABC（-12.5 Kcal/mol）和金黄色葡萄球菌的 MepR（-10.6 Kcal/mol）有显著的结合亲和力。根据研究结果，化合物 7b、7c 和 7e 与结核杆菌的两个重要靶标（即烯酰-[酰基载体蛋白]还原酶和拓扑异构酶 I）具有良好的结合亲和力。化合物 7b 对除白血病以外的所有癌症类型都显示出卓越的细胞毒性活性，其 GI50 值为 1.26-1.83 µM，LC50 值为 5.36-7.88 µM。化合物 7a 对结肠癌、黑色素瘤、卵巢癌、肾癌和乳腺癌细胞株具有显著的抗癌活性，其 GI50 值为 1.60-2.55 µM。

{"title":"Non-nucleophilic base promoted synthesis of azo-linked oxazolone-pyrazole hybrids: Antimicrobial, antitubercular, anticancer evaluations and in-silico modeling insights","authors":"Bonny Y. Patel , Vidhi Joshi , Sangeetha Subramanian , Gopal Italiya , Prasanna Srinivasan Ramalingam , Sivakumar Arumugam , Sanjay D. Hadiyal , Al-Anood Mohamed Al-Dies","doi":"10.1016/j.rechem.2024.101887","DOIUrl":"10.1016/j.rechem.2024.101887","url":null,"abstract":"<div><div>Ten new non-nucleophilic base (DBU) catalyzed oxazolone-bearing pyrazole derivatives were created to treat infectious diseases caused by bacterial, mycobacterial strains, and cancerous cell lines. Compounds 7b and 7c showed excellent antibacterial and antifungal activity. Compound 7b was highly effective against M. tuberculosis H37Rv, with a MIC of 0.06 μg/mL and significant binding affinities to AcrB of E. coli (−12 Kcal/mol), TriABC of P. aeruginosa (−12.5 Kcal/mol), and MepR of S. aureus (−10.6 Kcal/mol). Based on the findings, compounds 7b, 7c, and 7e exhibit proficient binding affinity with two essential targets, namely Enoyl-[acyl-carrier-protein] reductase and Topoisomerase I, of M. tuberculosis. Compound 7b showed superior cytotoxic activity against all cancer types except leukemia with GI50 values of 1.26–1.83 µM and LC50 values of 5.36–7.88 µM. Compound 7a demonstrated remarkable anticancer activity against colon, melanoma, ovarian, renal, and breast cancer cell lines with GI50 values of 1.60–2.55 µM.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"12 ","pages":"Article 101887"},"PeriodicalIF":2.5,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142661092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Ag–Te alloys on pH sensitivity of Ag2O–TeO2 glass/stainless steel enamel 银碲合金对 Ag2O-TeO2 玻璃/不锈钢搪瓷 pH 值敏感性的影响

IF 2.5 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry

Pub Date : 2024-11-05 DOI: 10.1016/j.rechem.2024.101889

Tadanori Hashimoto , Tomonari Kuno , Atsushi Ishihara , Takuhisa Komi , Yuji Nishio

Glass pH sensors are unsuitable for in vivo biomedical, clinical, or food applications because of brittleness of glass, the difficulty in measurement of small volumes and complex matrices, and the need for calibration. Herein, a novel enamel reference electrode for pH sensors is developed using a binary xAg₂O·(100–x)TeO₂ glass/stainless steel (SUS) electrode. Subsequently, the effects of Ag₂O content on the precipitated crystalline phases and pH sensitivity of Ag₂O–TeO₂ glass/SUS electrodes are examined. The results indicate that the xAg₂O·(100–x)TeO₂ glass/SUS samples exhibit relatively low pH sensitivity. The pH sensitivities of the samples can be classified into two distinct groups. The first group, comprising samples with an Ag₂O content of 25 mol% or more, exhibits a pH sensitivity higher than 10 %. The second group, comprising samples with an Ag₂O content of 22 mol% or less, exhibits a pH sensitivity of less than 10 %. The pH sensitivity tends to decrease with increase in stutzite fraction in Ag–Te alloys. Results of X-ray diffraction measurements and transmission electron microscopy observations indicate that the hessite and stutzite Ag–Te alloys, which are minor and conductive, are the primary contributors to the low pH sensitivity observed. Moreover, the pH sensitivity of xAg₂O·(100–x)TeO₂/SUS is observed to be between those of the Ag–Te alloy and the Ag₂O–TeO₂ glass matrix. We propose occurrence of an electrical shunt should occur between the Ag–Te alloy and the Ag⁺-ion conductive Ag₂O–TeO₂ glass matrix. Regarding xAg₂O·(100–x)TeO₂ glass/SUS, the 20Ag₂O·80TeO₂ glass/SUS to 21Ag₂O·79TeO₂ glass/SUS compositions represent promising candidates as for KCl-leakage-free reference electrodes for pH sensors.

由于玻璃易碎、难以测量小体积和复杂基质以及需要校准，玻璃 pH 传感器不适合用于体内生物医学、临床或食品应用。在此，我们使用二元 xAg2O-(100-x)TeO2 玻璃/不锈钢（SUS）电极开发了一种用于 pH 传感器的新型搪瓷参比电极。随后，研究了 Ag2O 含量对 Ag2O-TeO2 玻璃/SUS 电极析出结晶相和 pH 灵敏度的影响。结果表明，xAg2O-(100-x)TeO2 玻璃/SUS 样品的 pH 灵敏度相对较低。样品的 pH 灵敏度可分为两组。第一组包括 Ag2O 含量为 25 摩尔%或更高的样品，其 pH 灵敏度高于 10%。第二组样品的 Ag2O 含量为 22 摩尔%或更少，pH 灵敏度低于 10%。随着Ag-Te合金中斜方晶石含量的增加，pH值敏感性呈下降趋势。X 射线衍射测量和透射电子显微镜观察的结果表明，埃希石和直闪石 Ag-Te 合金具有微小的导电性，是造成 pH 灵敏度低的主要原因。此外，xAg2O-(100-x)TeO2/SUS 的 pH 灵敏度介于 Ag-Te 合金和 Ag2O-TeO2 玻璃基体之间。我们认为，Ag-Te 合金和导电 Ag+ 离子的 Ag2O-TeO2 玻璃基质之间应该存在电分流。关于 xAg2O-(100-x)TeO2 玻璃/SUS，20Ag2O-80TeO2 玻璃/SUS 到 21Ag2O-79TeO2 玻璃/SUS 组合是 pH 传感器无 KCl 泄漏参比电极的理想候选材料。

{"title":"Effect of Ag–Te alloys on pH sensitivity of Ag2O–TeO2 glass/stainless steel enamel","authors":"Tadanori Hashimoto , Tomonari Kuno , Atsushi Ishihara , Takuhisa Komi , Yuji Nishio","doi":"10.1016/j.rechem.2024.101889","DOIUrl":"10.1016/j.rechem.2024.101889","url":null,"abstract":"<div><div>Glass pH sensors are unsuitable for in vivo biomedical, clinical, or food applications because of brittleness of glass, the difficulty in measurement of small volumes and complex matrices, and the need for calibration. Herein, a novel enamel reference electrode for pH sensors is developed using a binary xAg2O·(100–x)TeO2 glass/stainless steel (SUS) electrode. Subsequently, the effects of Ag2O content on the precipitated crystalline phases and pH sensitivity of Ag2O–TeO2 glass/SUS electrodes are examined. The results indicate that the xAg2O·(100–x)TeO2 glass/SUS samples exhibit relatively low pH sensitivity. The pH sensitivities of the samples can be classified into two distinct groups. The first group, comprising samples with an Ag2O content of 25 mol% or more, exhibits a pH sensitivity higher than 10 %. The second group, comprising samples with an Ag2O content of 22 mol% or less, exhibits a pH sensitivity of less than 10 %. The pH sensitivity tends to decrease with increase in stutzite fraction in Ag–Te alloys. Results of X-ray diffraction measurements and transmission electron microscopy observations indicate that the hessite and stutzite Ag–Te alloys, which are minor and conductive, are the primary contributors to the low pH sensitivity observed. Moreover, the pH sensitivity of xAg2O·(100–x)TeO2/SUS is observed to be between those of the Ag–Te alloy and the Ag2O–TeO2 glass matrix. We propose occurrence of an electrical shunt should occur between the Ag–Te alloy and the Ag+-ion conductive Ag2O–TeO2 glass matrix. Regarding xAg2O·(100–x)TeO2 glass/SUS, the 20Ag2O·80TeO2 glass/SUS to 21Ag2O·79TeO2 glass/SUS compositions represent promising candidates as for KCl-leakage-free reference electrodes for pH sensors.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"12 ","pages":"Article 101889"},"PeriodicalIF":2.5,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142661095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation of nanocomposite hydrogel based on Fe3O4-TMSPM/poly(HEMA-PEG6MA-IA) for the removal of methylene blue dye from aqueous solution 制备基于 Fe3O4-TMSPM/poly(HEMA-PEG6MA-IA) 的纳米复合水凝胶以去除水溶液中的亚甲基蓝染料

IF 2.5 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry

Pub Date : 2024-11-03 DOI: 10.1016/j.rechem.2024.101888

Fiorela Ccoyo Ore , Ana María Lechuga Chacon , Rosana Leonor Aranzábal Carrasco , Flor de Liss Meza López , Ana Cecilia Valderrama Negrón , Michael Azael Ludeña Huaman

In this work, a new hydrogel poly(2-hydroxyethyl methacrylate-co-polyethylene glycol methacrylate-co-itaconic acid) poly(HEMA-PEG₆MA-IA) covalently crosslinked with Fe₃O₄ nanoparticles functionalized with 3-(trimethoxysilyl)propyl methacrylate organosilane (TMSPM) was prepared by free radicals, named Fe₃O₄-TMSPM/HG. FTIR-ATR, TGA, XRD, and TEM experiments were utilized to explore the Fe₃O₄-TMSPM/HG nanocomposite hydrogel. Swelling studies were also carried out in water, in different pH media, and then used in the adsorption of the cationic dye methylene blue (MB) from aqueous media. The factors controlling the adsorption process such as pH, dose, contact time, initial MB concentration, and temperature were investigated. The maximum MB adsorption capacity (270.27 mg/g) using Fe₃O₄-TMSPM/HG was obtained under the best conditions pH 8, dose 0.5 mg/mL, contact time 24 h, and ambient laboratory temperature (≈15 °C). The kinetic and isothermal experiments showed that the adsorption of MB followed the pseudo-second-order and Langmuir models. The effect of temperature on the adsorption capacity is related to the swelling, since the Fe₃O₄-TMSPM/HG nanocomposite hydrogel exhibit temperature-responsive. After 5 adsorption–desorption cycles, the adsorption decreased by 19 mg/g compared to the initial adsorption capacity. All the experimental results show that the prepared Fe₃O₄-TMSPM/HG nanocomposite hydrogel has the potential to be applied as an adsorbent for MB dye.

本研究采用自由基法制备了一种新型聚（2-羟乙基甲基丙烯酸酯-聚乙二醇甲基丙烯酸酯-衣康酸）聚（HEMA-PEG6MA-IA）水凝胶，该水凝胶与由 3-（三甲氧基硅基）丙基甲基丙烯酸酯有机硅烷（TMSPM）功能化的 Fe3O4 纳米粒子共价交联，命名为 Fe3O4-TMSPM/HG。利用 FTIR-ATR、TGA、XRD 和 TEM 实验对 Fe3O4-TMSPM/HG 纳米复合水凝胶进行了研究。还在水中和不同 pH 值的介质中进行了溶胀研究，然后用于吸附水介质中的阳离子染料亚甲基蓝（MB）。研究了控制吸附过程的因素，如 pH 值、剂量、接触时间、甲基溴初始浓度和温度。在 pH 值为 8、剂量为 0.5 mg/mL、接触时间为 24 h 和实验室环境温度（≈15 °C）的最佳条件下，Fe3O4-TMSPM/HG 获得了最大的甲基溴吸附容量（270.27 mg/g）。动力学和等温实验表明，甲基溴的吸附遵循伪二阶和朗缪尔模型。温度对吸附容量的影响与溶胀有关，因为 Fe3O4-TMSPM/HG 纳米复合水凝胶具有温度响应性。经过 5 次吸附-解吸循环后，吸附量比初始吸附量减少了 19 毫克/克。所有实验结果表明，制备的 Fe3O4-TMSPM/HG 纳米复合水凝胶具有作为 MB 染料吸附剂的潜力。

{"title":"Preparation of nanocomposite hydrogel based on Fe3O4-TMSPM/poly(HEMA-PEG6MA-IA) for the removal of methylene blue dye from aqueous solution","authors":"Fiorela Ccoyo Ore , Ana María Lechuga Chacon , Rosana Leonor Aranzábal Carrasco , Flor de Liss Meza López , Ana Cecilia Valderrama Negrón , Michael Azael Ludeña Huaman","doi":"10.1016/j.rechem.2024.101888","DOIUrl":"10.1016/j.rechem.2024.101888","url":null,"abstract":"<div><div>In this work, a new hydrogel poly(2-hydroxyethyl methacrylate-co-polyethylene glycol methacrylate-co-itaconic acid) poly(HEMA-PEG6MA-IA) covalently crosslinked with Fe3O4 nanoparticles functionalized with 3-(trimethoxysilyl)propyl methacrylate organosilane (TMSPM) was prepared by free radicals, named Fe3O4-TMSPM/HG. FTIR-ATR, TGA, XRD, and TEM experiments were utilized to explore the Fe3O4-TMSPM/HG nanocomposite hydrogel. Swelling studies were also carried out in water, in different pH media, and then used in the adsorption of the cationic dye methylene blue (MB) from aqueous media. The factors controlling the adsorption process such as pH, dose, contact time, initial MB concentration, and temperature were investigated. The maximum MB adsorption capacity (270.27 mg/g) using Fe3O4-TMSPM/HG was obtained under the best conditions pH 8, dose 0.5 mg/mL, contact time 24 h, and ambient laboratory temperature (≈15 °C). The kinetic and isothermal experiments showed that the adsorption of MB followed the pseudo-second-order and Langmuir models. The effect of temperature on the adsorption capacity is related to the swelling, since the Fe3O4-TMSPM/HG nanocomposite hydrogel exhibit temperature-responsive. After 5 adsorption–desorption cycles, the adsorption decreased by 19 mg/g compared to the initial adsorption capacity. All the experimental results show that the prepared Fe3O4-TMSPM/HG nanocomposite hydrogel has the potential to be applied as an adsorbent for MB dye.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"12 ","pages":"Article 101888"},"PeriodicalIF":2.5,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proximate analysis in biomass: Standards, applications and key characteristics 生物质的近似分析：标准、应用和主要特征

IF 2.5 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry

Pub Date : 2024-11-02 DOI: 10.1016/j.rechem.2024.101886

Diego Racero-Galaraga , Jesús D. Rhenals-Julio , Stiven Sofan-German , Jorge M. Mendoza , Antonio Bula-Silvera

Proximate analysis is a crucial method for characterizing biofuels, as it provides detailed information on moisture, volatile matter, ash, and fixed carbon content. This analysis is essential for evaluating the viability of biomass and optimizing its applications, particularly in renewable energy production. Understanding these parameters helps in comparing different biomass types and determining the best methods for their utilization or pretreatment to enhance efficiency. This study aims to address a gap in the literature by focusing specifically on biomass, in contrast to other fuels like coal and coke, which fall outside the scope of this research. A comprehensive literature review was conducted using the Web of Science database, with a focus on the standards, applications, and characteristics of proximate analysis as they pertain to biomass. The review was organized into four main categories: proximate analysis, volatiles, ash, and fixed carbon. While standards for proximate analysis are well-established for various materials, this study emphasizes the importance of specific protocols tailored to biomass to ensure accurate application. The findings suggest that a clearer understanding of the standards and characteristics of proximate analysis is essential for its accurate implementation and interpretation. This study addresses gaps in current practices and offers recommendations for future research.

生物量分析是鉴定生物燃料特性的重要方法，因为它能提供有关水分、挥发物、灰分和固定碳含量的详细信息。这种分析对于评估生物质的可行性和优化其应用至关重要，尤其是在可再生能源生产方面。了解这些参数有助于比较不同类型的生物质，并确定利用或预处理生物质的最佳方法，以提高效率。与煤炭和焦炭等其他燃料相比，生物质不属于本研究的范围，本研究旨在通过专门关注生物质来填补文献空白。本研究使用 Web of Science 数据库进行了全面的文献综述，重点关注生物质近似分析的标准、应用和特点。综述分为四大类：近似分析、挥发物、灰分和固定碳。虽然针对各种材料的近似物分析标准已经确立，但本研究强调了针对生物质制定具体方案以确保准确应用的重要性。研究结果表明，更清楚地了解近似分析的标准和特征对于准确实施和解释近似分析至关重要。本研究弥补了当前实践中的不足，并为今后的研究提出了建议。

{"title":"Proximate analysis in biomass: Standards, applications and key characteristics","authors":"Diego Racero-Galaraga , Jesús D. Rhenals-Julio , Stiven Sofan-German , Jorge M. Mendoza , Antonio Bula-Silvera","doi":"10.1016/j.rechem.2024.101886","DOIUrl":"10.1016/j.rechem.2024.101886","url":null,"abstract":"<div><div>Proximate analysis is a crucial method for characterizing biofuels, as it provides detailed information on moisture, volatile matter, ash, and fixed carbon content. This analysis is essential for evaluating the viability of biomass and optimizing its applications, particularly in renewable energy production. Understanding these parameters helps in comparing different biomass types and determining the best methods for their utilization or pretreatment to enhance efficiency. This study aims to address a gap in the literature by focusing specifically on biomass, in contrast to other fuels like coal and coke, which fall outside the scope of this research. A comprehensive literature review was conducted using the Web of Science database, with a focus on the standards, applications, and characteristics of proximate analysis as they pertain to biomass. The review was organized into four main categories: proximate analysis, volatiles, ash, and fixed carbon. While standards for proximate analysis are well-established for various materials, this study emphasizes the importance of specific protocols tailored to biomass to ensure accurate application. The findings suggest that a clearer understanding of the standards and characteristics of proximate analysis is essential for its accurate implementation and interpretation. This study addresses gaps in current practices and offers recommendations for future research.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"12 ","pages":"Article 101886"},"PeriodicalIF":2.5,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142587231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0