The Influence of Vitamins D and K on Some Biochemical, Cytochemical, and Clinical Blood Parameters In Vivo with Separate and Combined Administration

IF 0.4 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry Pub Date : 2025-03-18 DOI:10.1134/S1990750824601176

O. V. Popova, A. V. Mikhailov, G. P. Drobot, N. V. Turmukhametova, V. P. Manaeva, T. V. Ivanova, Y. A. Kupsoltseva, S. B. Mustafaeva, R. I. Bulgariev

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Abstract

A comprehensive study was conducted on the effect of vitamins D and K on some indicators of lipid peroxidation and the overall antioxidant activity of blood plasma in rats of two age groups. Differences in the studied parameters were revealed both in terms of age and under the influence of administered vitamins. An antioxidant effect of vitamin D is noted in adult animals, which is expressed in a significant decrease in the level of malondialdehyde (MDA) in blood plasma. In young people, a similar effect was found with the combined action of vitamins D and K. The content of lipids, glycogen, and cationic proteins in blood neutrophils of animals receiving vitamins D and K separately and together was analyzed. Significant changes in the content of cationic proteins were revealed when vitamin K was administered to adult animals. When analyzing the leukocyte formula, vitamin K and a complex of vitamins D and K showed the greatest effect, reflected in a change in the proportion of monocytes and lymphocytes. A negative correlation was shown between the lipid content in blood neutrophils and the level of one of the lipid peroxidation products, MDA, in blood plasma.

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维生素D和K分别和联合给药对体内某些生化、细胞化学和临床血液参数的影响

全面研究了维生素D和K对两个年龄组大鼠血脂过氧化指标及血浆整体抗氧化活性的影响。所研究的参数的差异显示在年龄和服用维生素的影响下。维生素D在成年动物中具有抗氧化作用，其表现为血浆中丙二醛（MDA）水平的显著降低。在年轻人中，维生素D和K的联合作用也有类似的效果。对单独和一起服用维生素D和K的动物血液中性粒细胞中的脂质、糖原和阳离子蛋白含量进行了分析。成年动物服用维生素K后，阳离子蛋白的含量发生了显著变化。在分析白细胞配方时，维生素K和维生素D和K的复合物的效果最大，反映在单核细胞和淋巴细胞比例的变化上。血液中性粒细胞中的脂质含量与血浆中脂质过氧化产物之一丙二醛的水平呈负相关。

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Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

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1.10

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期刊介绍： Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry covers all major aspects of biomedical chemistry and related areas, including proteomics and molecular biology of (patho)physiological processes, biochemistry, neurochemistry, immunochemistry and clinical chemistry, bioinformatics, gene therapy, drug design and delivery, biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine. The journal also publishes review articles. All issues of the journal usually contain solicited reviews.