Blood culture collection and administration of intravenous ceftriaxone by paramedics in patients with suspected sepsis (the pass trial)

IF 1.7 4区医学 Q2 EMERGENCY MEDICINE Emergency Medicine Australasia Pub Date : 2025-03-18 DOI:10.1111/1742-6723.70027

Daniel Cudini BEx Sci, BEmergHlth (Paramedic), Grad Dip EmergHlth (ICP), MACPara, Karen Smith BSc(Hons), Grad Cert Exec BA, Grad Dip Epi and Biostats, PhD, OAM, Jeffery Shao BMedSc/MD, Stephen Bernard MBBS, MD, FACEM, FCICM, FCCM, ASM, Daniel Okyere MBBS, MPH, Ziad Nehme BEmergHlth(Paramedic)(Hons), Grad Cert Clin Research Methods, PhD, FACPara, ASM, Emily Nehme BSc(Biomedical), MBiostat, PhD Candidate, David Anderson MStJ, BSc, MBChB, MBioeth, DipPallMed, FCICM, ASM, Nicole Magnuson BSc, MPH, Karin Thursky MBBS, BSc, MD, FRACP, Dhruv Mori MBBS, FACEM, De Witt Oosthuizen M.B.ChB, Dip EM, AMC, FACRRM, Andrew Udy BSc(Hons), Grad Cert Exec BA, Grad Dip Epi and Biostats, PhD

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引用次数: 0

Abstract

Objective

To evaluate the feasibility of pre-hospital blood culture (BC) collection and intravenous (IV) antibiotic administration in patients with suspected sepsis.

Methods

In this open-label trial, BCs were collected in all participants, who were then randomised to ongoing care (control) or ongoing care plus 2 g IV ceftriaxone (intervention). Time to antibiotic administration was the primary outcome.

Results

Thirty-five patients were enrolled and randomised (21 control, 14 intervention). BCs were obtained in 89% (n = 31/35) and grew a pathogen in 42% (n = 13/31). Intervention patients received antibiotics a median of 108 (95% CI 34 to 170) minutes earlier (P < 0.01).

Conclusion

BCs were successfully obtained by paramedics, and pre-hospital IV ceftriaxone resulted in expedited antibiotic administration.

Clinical Trial Registration: ACTRN12618000199213.

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来源期刊

Emergency Medicine Australasia 医学-急救医学

CiteScore

3.70

自引率

13.00%

发文量

217

审稿时长

6-12 weeks

期刊介绍： Emergency Medicine Australasia is the official journal of the Australasian College for Emergency Medicine (ACEM) and the Australasian Society for Emergency Medicine (ASEM), and publishes original articles dealing with all aspects of clinical practice, research, education and experiences in emergency medicine. Original articles are published under the following sections: Original Research, Paediatric Emergency Medicine, Disaster Medicine, Education and Training, Ethics, International Emergency Medicine, Management and Quality, Medicolegal Matters, Prehospital Care, Public Health, Rural and Remote Care, Technology, Toxicology and Trauma. Accepted papers become the copyright of the journal.