Wei-hua Sun, Lu-lu Yang, Chen-chen Wu, Wen-di Zhao, Li Xue
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引用次数: 0
Abstract
Objective: To identify risk factors associated with nonalcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes (T2DM) and provide a basis for improved prevention and treatment strategies for NAFLD.
Methods: A total of 156 hospitalized patients with T2DM were enrolled and divided into NAFLD and non-NAFLD groups (75 and 81 patients, respectively) based on the ultrasonic diagnosis results. Biochemical data were collected from all patients. A bioelectrical impedance analyzer (OMRON, HDS-2000 DUALSCANR) was used to analyze visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) in the abdomen. Statistical analyses were conducted using SPSS 22.0 software.
Results: Statistically significant differences were observed between the NAFLD and non-NAFLD groups in body weight, body mass index (BMI), waist and hip circumference (WC and HC), waist-to-hip ratio (WHR), fasting C-peptide (FCP), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (GGT), total triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), apolipoprotein B (apoB), superoxide dismutase (SOD), free fatty acids (FFA), VAT, and SAT (all p < 0.05). VAT was positively correlated with BMI (r = 0.703, p < 0.001), WC (r = 0.685, p < 0.001), HC (r = 0.547, p < 0.001), SAT (r = 0.774, p < 0.001), TG (r = 0.365, p < 0.001), FCP (r = 0.287, p < 0.001), ALT (r = 0.282, p < 0.001), and GGT (r = 0.273, p = 0.001) and negatively correlated with HDL-C (r = −0.201, p = 0.012). Multivariable logistic regression analysis indicated that VAT and FFA are independent influencing factors for NAFLD (p < 0.01). A receiver operating characteristic curve showed that the sensitivity and specificity of VAT for predicting NAFLD in T2DM were 88.0% and 57.8%, respectively.
Conclusions: VAT and FFA are independent risk factors for NAFLD in patients with T2DM, with VAT serving as a reliable predictor for NAFLD screening. Screening for NAFLD should not be limited to overweight or obese individuals; attention should also be given to nonobese and lean patients.
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