A Linkage Between 25-Hydroxyvitamin D and Post-Stroke Cognitive Impairment, as Well as the Duration of Hospitalization After a Stroke

IF 2.1 4区医学 Q3 HEALTH CARE SCIENCES & SERVICES Journal of evaluation in clinical practice Pub Date : 2025-03-18 DOI:10.1111/jep.70039

Jianrong Xiong, Yongxiang Li, Jinhui Li, Chenliang Zhao

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Abstract

Aims

A variety of complications can arise following a stroke, with post-stroke cognitive impairment (PSCI) being a prevalent consequence. The objective of the research was to explore the relationship between 25(OH)D levels, PSCI, and the duration of hospitalization.

Methods

Serum concentrations of 25(OH)D were measured within the first 24 h of hospital admission. Cognitive impairment in stroke patients was assessed using the Mini-Mental State Examination (MMSE). Functional independence was evaluated on the day of discharge using the Barthel Index (BI). Additionally, the duration of hospitalization for each patient was recorded. Data analysis was performed using SPSS statistical software.

Results

An observation revealed that levels of 25(OH)D were comparatively reduced in stroke people who suffered from cognitive impairment as opposed to individuals without such impairment (p = 0.022). Patients with cognitive impairment following a stroke demonstrated reduced BI scores (p < 0.001) and longer durations of hospitalization (p = 0.002) in contrast to patients without cognitive impairment. Upon comparing groups with different concentrations of 25(OH)D, it was observed that individuals with low concentrations had longer hospitalization durations (p = 0.03) and higher NIHSS scores (p = 0.003) than those with high concentrations of 25(OH)D. Furthermore, binary logistic regression analysis indicated that a 25(OH)D level of < 25 nmol/L was a significant risk factor for cognitive impairment following a stroke.

Conclusions

The study indicated a potential linkage between reduced levels of 25(OH)D and an escalated susceptibility to cognitive impairment following a stroke. Furthermore, individuals with lower concentrations of 25(OH)D generally experienced longer hospital stays.

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25-羟基维生素D与脑卒中后认知障碍以及脑卒中后住院时间之间的联系

卒中后可出现多种并发症，卒中后认知障碍（PSCI）是一种普遍的后果。本研究的目的是探讨25(OH)D水平、PSCI和住院时间之间的关系。方法在入院前24 h内测定血清25(OH)D浓度。脑卒中患者的认知障碍采用简易精神状态检查（MMSE）进行评估。出院当天采用Barthel指数（BI）评价功能独立性。此外，还记录了每位患者的住院时间。采用SPSS统计软件进行数据分析。结果一项观察显示，与没有认知障碍的人相比，患有认知障碍的中风患者的25(OH)D水平相对降低（p = 0.022）。与无认知障碍的患者相比，卒中后认知障碍患者BI评分降低（p < 0.001），住院时间延长（p = 0.002）。对比不同浓度25(OH)D组，低浓度个体住院时间较长（p = 0.03）， NIHSS评分高于高浓度个体（p = 0.003）。此外，二元logistic回归分析表明，25(OH)D水平为25 nmol/L是脑卒中后认知功能障碍的重要危险因素。结论：研究表明25(OH)D水平降低与中风后认知障碍易感性升高之间存在潜在联系。此外，25(OH)D浓度较低的个体通常住院时间较长。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of evaluation in clinical practice 医学-卫生保健

CiteScore

4.80

自引率

4.20%

发文量

143

审稿时长

3-8 weeks

期刊介绍： The Journal of Evaluation in Clinical Practice aims to promote the evaluation and development of clinical practice across medicine, nursing and the allied health professions. All aspects of health services research and public health policy analysis and debate are of interest to the Journal whether studied from a population-based or individual patient-centred perspective. Of particular interest to the Journal are submissions on all aspects of clinical effectiveness and efficiency including evidence-based medicine, clinical practice guidelines, clinical decision making, clinical services organisation, implementation and delivery, health economic evaluation, health process and outcome measurement and new or improved methods (conceptual and statistical) for systematic inquiry into clinical practice. Papers may take a classical quantitative or qualitative approach to investigation (or may utilise both techniques) or may take the form of learned essays, structured/systematic reviews and critiques.