Photon-Efficient, Hybrid Illumination for High-Throughput Fourier Ptychographic Phase Microscopy Using Lenslet-Integrated LED Illuminator (Laser Photonics Rev. 19(6)/2025)

Abstract

Improved Illumination for FPM

Using a photon-efficient LED illuminator integrated with a lenslet array and hybrid multiplexed illumination scheme, Chulmin Joo and co-workers have created a high-throughput computational imaging platform capable of stitching-free, dynamic quantitative phase imaging. In article number 2401544, they explain how this platform achieves a fourfold enhancement in spatial resolution beyond the coherent diffraction limit based on Fourier ptychographic microscopy, while requiring few images with a total acquisition time of <40 ms. Its stitching-free dynamic imaging capabilities are demonstrated through imaging flowing red blood cells, highlighting its potential for a broad range of applications that call for high-resolution, dynamic imaging across large spatial scales.