Yingying Jiang, Hang Zhao, Lunjie Chen, Siping Wei, Jun Wang, Lin Wang, Qiang Fu
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引用次数: 0
Abstract
The synthesis of pomalidomide-conjugates, crucial intermediates for developing PROTACs, has suffered from prolonged reaction times and extensive byproduct formation. Herein, we present a methodology that overcomes these limitations, achieving complete reaction within minutes while minimizing side products. By shortening reaction timeframes, our method would facilitate exploration of novel pomalidomide-based PROTACs.
期刊介绍:
ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.