Electron dose optimisation based on tumour thickness and shape for photon multi-leaf collimated megavoltage electrons

IF 1.6 3区工程技术 Q3 CHEMISTRY, INORGANIC & NUCLEAR Applied Radiation and Isotopes Pub Date : 2025-03-14 DOI:10.1016/j.apradiso.2025.111785

D. van Eeden, F.C.P. du Plessis

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Abstract

This study developed an optimisation method that considers tumour thickness for modulated electron radiation treatment (MERT) at a treatment distance of 60 cm. It comprises forming a tumour bed matrix from which a transformed tumour bed matrix is derived. From the discrete tumour bed depth data, electron beam segments were extracted, which were further decomposed into sub-beams. The EGSnrc-based Monte Carlo codes BEAMnrc and DOSXYZnrc were used to model a linear accelerator and to score 3-D dose data for various field sizes (sub-beams) in a water phantom model.

The use of different energy and intensity-modulated electron sub-beams to irradiate a parotid lesion was investigated by applying the developed optimisation method. After each sub-beam energy was determined, a least square cost function minimisation was invoked to deliver a minimum dose to the tumour volume and produce a set of weight factors synonymous with beam intensity modulation.

This study describes a technique to derive apertures and suitable sub-beam energy to provide a method for planning a robust MERT technique that yields dose-covering results and dose spread within the tumour that aligns with literature studies.

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来源期刊

Applied Radiation and Isotopes 工程技术-核科学技术

CiteScore

3.00

自引率

12.50%

发文量

406

审稿时长

13.5 months

期刊介绍： Applied Radiation and Isotopes provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and peaceful application of nuclear, radiation and radionuclide techniques in chemistry, physics, biochemistry, biology, medicine, security, engineering and in the earth, planetary and environmental sciences, all including dosimetry. Nuclear techniques are defined in the broadest sense and both experimental and theoretical papers are welcome. They include the development and use of α- and β-particles, X-rays and γ-rays, neutrons and other nuclear particles and radiations from all sources, including radionuclides, synchrotron sources, cyclotrons and reactors and from the natural environment. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. Papers dealing with radiation processing, i.e., where radiation is used to bring about a biological, chemical or physical change in a material, should be directed to our sister journal Radiation Physics and Chemistry.