Wide-field quantitative phase imaging without slicing via feature-domain Fourier ptychographic microscopy

Abstract

Quantitative phase imaging (QPI) is gaining significant recognition in the field of biological imaging due to its ability to accurately and non-invasively retrieve phase shifts within samples. Fourier ptychographic microscopy (FPM) is a high-resolution imaging technology commonly employed for QPI because of its capability to capture a vast field of view and recover phase information. Typically, FPM requires an initial image with a high signal-to-noise ratio. To address its theoretical constraints, the image is often divided into blocks for processing. This letter presents the implementation of a quantitative phase imaging method based on the recently introduced feature-domain Fourier ptychographic technique. The proposed method is designed to be robust against noise and eliminates the need for binning the original image. Compared with conventional methods, our approach demonstrates high performance and flexible recovery results in both simulations and experiments.