Immobilization of gold nanoparticles on electrospun polyacrylonitrile/carbon nanotube nanofiber for self-powered electrochemical biosensing of myoglobin

IF 4.7 3区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY Materials Chemistry and Physics Pub Date : 2025-07-15 Epub Date: 2025-03-14 DOI:10.1016/j.matchemphys.2025.130722

Mingye Zhao , Ling Wang , Hui Xu

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Abstract

Polyacrylonitrile-carbon nanotube (PAN-CNT) nanofibers were prepared on indium tin oxide (ITO) electrode using electrospinning technique, and gold nanoparticles (AuNPs) were subsequently modified on ITO-PAN-CNT electrode by electrostatic adsorption to construct ITO-PAN-CNT–COOH–AuNPs substrate electrode. The self-powered biosensor consists of a PAN-CNT–COOH–AuNPs-aptamer functionalized biocathode and a PAN-CNT–COOH–AuNPs-glucose oxidase (GO_x) bioanode. By capturing the change in electrode spatial potential resistance before and after myoglobin (Mb), This interaction affects the transmission of electrons between the redox probe [Fe(CN)₆]^3- an d the biocathode, establishing a linear relationship between E^OCV and Mb concentration. The self-powered biosensor displayed a highly sensitive response to the target Mb over a concentration range from 5 to 5 × 10³ ng mL⁻¹, with a limit of detection reaching less than 0.23 ng mL⁻¹ (S/N = 3), and exhibited outstanding stability and selectivity.

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电纺聚丙烯腈/碳纳米管纳米纤维固定化金纳米粒子用于肌红蛋白的自供电电化学生物传感

采用静电纺丝技术在氧化铟锡（ITO）电极上制备了聚丙烯腈-碳纳米管（PAN-CNT）纳米纤维，随后在ITO-PAN-CNT电极上采用静电吸附修饰金纳米粒子（AuNPs），构建了ITO-PAN-CNT - cooh - AuNPs衬底电极。该自供电生物传感器由pan - cnt - cooh - aunps适体功能化生物阴极和pan - cnt - cooh - aunps葡萄糖氧化酶（GOx）生物阳极组成。通过捕捉肌红蛋白（Mb）前后电极空间电位电阻的变化，这种相互作用影响了氧化还原探针[Fe(CN)6]3-与生物阴极之间的电子传输，建立了EOCV与Mb浓度之间的线性关系。在5 ~ 5 × 103 ng mL−1的浓度范围内，该自驱动生物传感器对目标物Mb具有高度敏感的响应，检测限小于0.23 ng mL−1 (S/N = 3)，具有良好的稳定性和选择性。

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来源期刊

Materials Chemistry and Physics 工程技术-材料科学：综合

CiteScore

8.70

自引率

4.30%

发文量

1515

审稿时长

69 days

期刊介绍： Materials Chemistry and Physics is devoted to short communications, full-length research papers and feature articles on interrelationships among structure, properties, processing and performance of materials. The Editors welcome manuscripts on thin films, surface and interface science, materials degradation and reliability, metallurgy, semiconductors and optoelectronic materials, fine ceramics, magnetics, superconductors, specialty polymers, nano-materials and composite materials.