Innovative approaches in bioadhesive design: A comprehensive review of crosslinking methods and mechanical performance

IF 6 2区 医学 Q2 MATERIALS SCIENCE, BIOMATERIALS Materials Science & Engineering C-Materials for Biological Applications Pub Date : 2025-08-01 Epub Date: 2025-03-14 DOI:10.1016/j.bioadv.2025.214287
Asef Raj , Sabrina Sharmin , Safrin Jannat , Saika Ahmed , Abu Bin Ihsan
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Abstract

In biomedical applications, bioadhesives have become a game-changer, offering novel approaches to tissue engineering, surgical adhesion, and wound healing. This comprehensive review paper provides a thorough analysis of bioadhesives and their categorization according to application site and crosslinking process, bonding efficacy, and mechanical characteristics. The use of bioadhesives to stop bleeding and seal leaks is also covered in the review. The article delves into the various crosslinking techniques used in bioadhesives, including chemical, physical, and hybrid approaches. It emphasizes on how these mechanisms control the adhesive's elasticity, durability, and structural integrity. In addition, the review looks at the mechanical strength of bioadhesives, taking important characteristics like shear strength, toughness, elasticity, and tensile strength into account. It is highlighted how important bioadhesives are to the life sciences because they drive innovation and interdisciplinary cooperation, address present healthcare issues, and create new avenues for therapeutic development. The paper also explores some vital characteristics of bioadhesives that, when strategically combined with one another, improve their efficacy and usefulness in a variety of surgical and medical applications. The analysis concludes by examining nature-inspired adhesives, including those based on geckos, mussels, and tannic acid, and their unique bonding mechanisms and potential for use in advanced biomedical applications.

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生物粘合剂设计的创新方法:交联方法和机械性能的综合综述
在生物医学应用中,生物胶粘剂已经成为游戏规则的改变者,为组织工程、手术粘连和伤口愈合提供了新的方法。本文从应用领域、交联过程、粘接效果和力学特性等方面对生物胶粘剂的分类进行了全面分析。使用生物胶粘剂止血和密封泄漏也包括在审查中。本文深入研究了生物胶粘剂中使用的各种交联技术,包括化学,物理和混合方法。它强调了这些机制如何控制粘合剂的弹性,耐久性和结构完整性。此外,该综述着眼于生物胶粘剂的机械强度,考虑了剪切强度、韧性、弹性和拉伸强度等重要特性。它强调了生物粘合剂对生命科学的重要性,因为它们推动了创新和跨学科合作,解决了当前的医疗保健问题,并为治疗开发创造了新的途径。本文还探讨了生物胶粘剂的一些重要特性,当它们有策略地相互结合时,可以提高它们在各种外科和医学应用中的功效和有用性。分析的结论是考察了受自然启发的粘合剂,包括基于壁虎、贻贝和单宁酸的粘合剂,以及它们独特的粘合机制和在先进生物医学应用中的潜力。
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来源期刊
CiteScore
17.80
自引率
0.00%
发文量
501
审稿时长
27 days
期刊介绍: Biomaterials Advances, previously known as Materials Science and Engineering: C-Materials for Biological Applications (P-ISSN: 0928-4931, E-ISSN: 1873-0191). Includes topics at the interface of the biomedical sciences and materials engineering. These topics include: • Bioinspired and biomimetic materials for medical applications • Materials of biological origin for medical applications • Materials for "active" medical applications • Self-assembling and self-healing materials for medical applications • "Smart" (i.e., stimulus-response) materials for medical applications • Ceramic, metallic, polymeric, and composite materials for medical applications • Materials for in vivo sensing • Materials for in vivo imaging • Materials for delivery of pharmacologic agents and vaccines • Novel approaches for characterizing and modeling materials for medical applications Manuscripts on biological topics without a materials science component, or manuscripts on materials science without biological applications, will not be considered for publication in Materials Science and Engineering C. New submissions are first assessed for language, scope and originality (plagiarism check) and can be desk rejected before review if they need English language improvements, are out of scope or present excessive duplication with published sources. Biomaterials Advances sits within Elsevier''s biomaterials science portfolio alongside Biomaterials, Materials Today Bio and Biomaterials and Biosystems. As part of the broader Materials Today family, Biomaterials Advances offers authors rigorous peer review, rapid decisions, and high visibility. We look forward to receiving your submissions!
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