Decreased Serum and Salivary Levels of Aquaporin 5 in Oral Lichen Planus

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Clinical and Experimental Dental Research Pub Date : 2025-03-18 DOI:10.1002/cre2.70107

Farzaneh Agha-Hosseini, Yalda Elham, Iraj Mirzaei-Dizgah, Mahdieh-Sadat Moosavi

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引用次数: 0

Abstract

Objectives

Oral lichen planus (OLP) is an autoimmune disease with unknown etiology. Many OLP patients complain of xerostomia, and studies are still ongoing to find the reason for this manifestation. Aquaporin 5 has been expressed in salivary glands, and its physiological significance in transferring water as transcellular is properly identified. In this study, for the first time, we have investigated the serum and salivary levels of aquaporin 5 (as a salivary gland biomarker) in oral lichen planus patients with xerostomia.

Material and Methods

Thirty patients with OLP and xerostomia and 30 healthy individuals were chosen. The flow of stimulatory and non-stimulatory saliva was calculated, and the serums, in addition to salivary levels of aquaporin 5, were determined.

Results

The level of Aquaporin 5 in serum and its output in stimulatory, and non-stimulatory saliva were significantly decreased, the stimulatory and non-stimulatory saliva flow was reduced, and the degree of xerostomia was significantly higher in the OLP group.

Conclusions

Aquaporin 5 is implicated in OLP patients in several ways such as impaired salivary functioning, xerostomia or dry mouth, diminished repair ability of the mucosal lesion, increased apoptosis, and probable carcinogenesis in this premalignant lesion.

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IF 0 Vojenské reflexiePub Date : 1900-01-01 DOI: 10.52651/vr.a.2022.1.108-130

Michal Vajda

来源期刊

Clinical and Experimental Dental Research DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.30

自引率

5.60%

发文量

165

审稿时长

26 weeks

期刊介绍： Clinical and Experimental Dental Research aims to provide open access peer-reviewed publications of high scientific quality representing original clinical, diagnostic or experimental work within all disciplines and fields of oral medicine and dentistry. The scope of Clinical and Experimental Dental Research comprises original research material on the anatomy, physiology and pathology of oro-facial, oro-pharyngeal and maxillofacial tissues, and functions and dysfunctions within the stomatognathic system, and the epidemiology, aetiology, prevention, diagnosis, prognosis and therapy of diseases and conditions that have an effect on the homeostasis of the mouth, jaws, and closely associated structures, as well as the healing and regeneration and the clinical aspects of replacement of hard and soft tissues with biomaterials, and the rehabilitation of stomatognathic functions. Studies that bring new knowledge on how to advance health on the individual or public health levels, including interactions between oral and general health and ill-health are welcome.