Precise Methylation Detection of Tumor Suppressor Gene Promoters by Magnetic Enrichment and Nano Silver Adduct–Promoted Surface-Enhanced Raman Scattering (Small 11/2025)
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引用次数: 0
Abstract
Methylation Detection
The gene adduct-modified silver cluster enables specific labeling of the methylation site on the tumor suppressor promoter. This cutting-edge system utilizes gene-hybridizable nanobeads for magnetic enrichment, ensuring targeted and efficient gene sample preparation. Silver-promoted surface-enhanced Raman scattering amplifies the 5-methyl cytosine signal, while localized hot spots around methylated and unmethylated promoters ensure precise methylation detection. More in article number 2407517, Yi-Hsin Chien, Wei-Peng Li, and co-workers.
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Small serves as an exceptional platform for both experimental and theoretical studies in fundamental and applied interdisciplinary research at the nano- and microscale. The journal offers a compelling mix of peer-reviewed Research Articles, Reviews, Perspectives, and Comments.
With a remarkable 2022 Journal Impact Factor of 13.3 (Journal Citation Reports from Clarivate Analytics, 2023), Small remains among the top multidisciplinary journals, covering a wide range of topics at the interface of materials science, chemistry, physics, engineering, medicine, and biology.
Small's readership includes biochemists, biologists, biomedical scientists, chemists, engineers, information technologists, materials scientists, physicists, and theoreticians alike.
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