The role of lifestyle in the impact of constant phthalate exposure on overweight and obesity: A longitudinal cohort study in China.

IF 2.7 3区医学 Q1 PEDIATRICS Pediatric Obesity Pub Date : 2025-03-17 DOI:10.1111/ijpo.70011

Tongjun Guo, Yi Zhang, Li Chen, Jieyu Liu, Jianuo Jiang, Wen Yuan, Ruolin Wang, Qi Ma, Manman Chen, Jun Ma, Zhiyong Zou, Yanhui Dong

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引用次数: 0

Abstract

Background and objectives: To explore the relationship between constant exposure to phthalates (PAEs) and overweight/obesity and the role of lifestyle in children.

Methods: This study conducted five repeated follow-up visits with 829 children and analysed data from 740 children. Logistic regression models were used to evaluate the association between constant PAE exposure, lifestyle and overweight/obesity.

Results: The study found that constant high levels of PAEs exposure may increase the risk of obesity in girls, and the risk is higher in girls with an unhealthy lifestyle. In the unhealthy lifestyle group of girls, compared with the constant low (CL) exposure group of PAEs, the odds ratios (ORs) for overweight/obesity and obesity in the constant high (CH) exposure group were 2.99 (1.11, 8.05) and 11.58 (1.38, 96.87), respectively. In addition, an interaction effect between constant exposure to PAEs and lifestyle was observed on obesity in girls.

Conclusion: These results suggest the importance of reducing constant exposure to high levels of PAEs to reduce the risk of obesity, especially in individuals with unhealthy lifestyles. The government should strengthen the formulation of regulations and standards for PAEs while guiding parents to use fewer plastic products.

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.